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Small nuclear ribonucleoprotein D1 polypeptide 16kDa

SmD1, RDR2, Sm-D autoantigen
This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, Dicer, CAN, sMD-2, Cdc4
Papers on SmD1
JMJ24 binds to RDR2 and is required for the basal level transcription of silenced loci in Arabidopsis.
Chua et al., New York City, United States. In Plant J, Sep 2015
We also provide evidence of a physical association between JMJ24 and RNA-dependent RNA polymerase 2 (RDR2), which represents an evolved property of the RNA silencing pathway.
SmD1 Modulates the miRNA Pathway Independently of Its Pre-mRNA Splicing Function.
Zhou et al., Oxford, United Kingdom. In Plos Genet, Aug 2015
Here, we show that SmD1, a core component of the Drosophila small nuclear ribonucleoprotein particle (snRNP) implicated in splicing, is required for miRNA biogenesis and function.
Genome-wide view of natural antisense transcripts in Arabidopsis thaliana.
Chen et al., Hangzhou, China. In Dna Res, Jun 2015
NAT-siRNAs are typically 21nt, and are processed by Dicer-like 1 (DCL1)/DCL2 and RDR6 and function in epigenetically activated situations, or 24nt, suggesting these are processed by DCL3 and RDR2 and function in environment stress.
Regulation of a maize HD-ZIP IV transcription factor by a non-conventional RDR2-dependent small RNA.
Vernoud et al., Lyon, France. In Plant J, Mar 2015
The biogenesis of small1 depends on DICER-like 3 (DCL3), RNA-dependent RNA polymerase 2 (RDR2) and RNA polymerase IV, components that are usually required for RNA-dependent DNA-methylation.
Primer-dependent and primer-independent initiation of double stranded RNA synthesis by purified Arabidopsis RNA-dependent RNA polymerases RDR2 and RDR6.
Crété et al., Marseille, France. In Plos One, 2014
In Arabidopsis thaliana genetic studies have demonstrated that RDR2 and RDR6 are involved in the synthesis of double stranded RNA (dsRNA) from single stranded RNA (ssRNA) targeted by RNA silencing.
Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis.
Pikaard et al., Bloomington, United States. In Elife, 2014
24 nt siRNA biogenesis requires nuclear RNA polymerase IV (Pol IV), RNA-dependent RNA polymerase 2 (RDR2) and DICER-like 3 (DCL3).
Pediatric Patients with Vitiligo in Eastern China: Abnormalities in 145 Cases Based on Thyroid Function Tests and Immunological Findings.
Wei et al., Xuzhou, China. In Med Sci Monit, 2014
Anti-SSA/Ro-60 and anti-SSA/Ro-52 were the most prevalent antibodies, followed by anti-dsDNA and then by anti-SmD1 and CENB-P.
miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis.
Martienssen et al., New York City, United States. In Nature, 2014
In plants, post-transcriptional gene silencing (PTGS) is mediated by DICER-LIKE 1 (DCL1)-dependent microRNAs (miRNAs), which also trigger 21-nucleotide secondary short interfering RNAs (siRNAs) via RNA-DEPENDENT RNA POLYMERASE 6 (RDR6), DCL4 and ARGONAUTE 1 (AGO1), whereas transcriptional gene silencing (TGS) of transposons is mediated by 24-nucleotide heterochromatic (het)siRNAs, RDR2, DCL3 and AGO4 (ref.
Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly.
Dreyfuss et al., Philadelphia, United States. In Cell, 2011
Here, we describe the 2.5 Å crystal structure of Gemin2 bound to SmD1/D2/F/E/G pentamer and SMN's Gemin2-binding domain, a key assembly intermediate.
SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.
Jacobsen et al., Los Angeles, United States. In Plos Genet, 2011
Data show that SHH1(AT1G15215), RDR2, CLASSY1, and RDM4 were co-purified with NRPD1(At1g63020), the largest subunit of Pol-IV.
Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Li et al., Cambridge, United Kingdom. In Nature, 2011
Four of the five major components of the spliceosome, U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), contain seven Sm proteins (SmB/B', SmD1, SmD2, SmD3, SmE, SmF and SmG) in common.
Sm peptides in differentiation of autoimmune diseases.
Mahler, San Diego, United States. In Adv Clin Chem, 2010
It has been shown that the polypeptides D1, D3, and BB' contain symmetrical dimethylarginine, constituting a major autoepitope within the C-terminus of SmD1 and SmD3.
Loss of RNA-dependent RNA polymerase 2 (RDR2) function causes widespread and unexpected changes in the expression of transposons, genes, and 24-nt small RNAs.
Schnable et al., Ames, United States. In Plos Genet, 2009
RDR2 plays a significant role in regulating the expression of not only transposons, but also of genes.
RNA-directed DNA methylation and demethylation in plants.
Zhu et al., Riverside, United States. In Sci China C Life Sci, 2009
In plants, double stranded-RNAs (dsRNAs) generated by RNA-dependent RNA polymerase 2 (RDR2) serve as precursors for Dicer-like 3 dependent biogenesis of 24-nt siRNAs.
Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis.
Carroll et al., Australia. In Proc Natl Acad Sci U S A, 2007
RDR2 is required for reception of long-distance mRNA silencing.
Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways.
Voinnet et al., Strasbourg, France. In Nat Genet, 2007
We found that SMD1 and SMD2, required for intercellular but not intracellular RNAi, are allelic to RDR2 and NRPD1a, respectively, previously implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4.
The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center.
Pikaard et al., Saint Louis, United States. In Cell, 2006
In Arabidopsis thaliana, small interfering RNAs (siRNAs) direct cytosine methylation at endogenous DNA repeats in a pathway involving two forms of nuclear RNA polymerase IV (Pol IVa and Pol IVb), RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), DICER-LIKE 3 (DCL3), ARGONAUTE4 (AGO4), the chromatin remodeler DRD1, and the de novo cytosine methyltransferase DRM2.
MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by argonaute, dicer, and RNA-dependent RNA polymerase in Arabidopsis.
Martienssen et al., New York City, United States. In Plant Cell, 2006
Data show that small interfering RNAs and larger RNA fragments corresponding miRNA target genes accumulate in wild-type plants but not in ago1, the RNA-dependent RNA polymerase mutants rdr2 and rdr6, or the Dicer-like mutants dcl1 and dcl3.
Cell biology of the Arabidopsis nuclear siRNA pathway for RNA-directed chromatin modification.
Pikaard, Saint Louis, United States. In Cold Spring Harb Symp Quant Biol, 2005
In Arabidopsis thaliana, the pathway for transcriptional silencing via RNA-directed DNA methylation and chromatin modification involves two forms of nuclear RNA polymerase IV (pol IVa and pol IVb), RNA-DEPENDENT RNA POLYMERASE2 (RDR2), DICER-LIKE3 (DCL3), ARGONAUTE4 (AGO4), the chromatin remodeler, DRD1, and the de novo cytosine methyltransferase, DRM2.
Intravenous injection of a D1 protein of the Smith proteins postpones murine lupus and induces type 1 regulatory T cells.
Hiepe et al., Berlin, Germany. In J Immunol, 2004
SmD1 83-119 peptide may play a dominant role in the activation of helper and regulatory T cells that influence autoantibody generation and murine lupus.
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