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Structural maintenance of chromosomes 1A

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Atm, MUC4, HAD, Scc1
Papers using SMC1 antibodies
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana.
Copenhaver Gregory P., In PLoS Genetics, 2005
... The construction of the SB1 expressing transgenic lines ...
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays.
Bereswill Stefan, In PLoS ONE, 2000
... UAS-PGRP-SB1 transgenic flies, a full-length cDNA of ...
Papers on SMC1
SMC1 promotes epithelial-mesenchymal transition in triple-negative breast cancer through upregulating Brachyury.
Wang et al., Shanghai, China. In Oncol Rep, Feb 2016
Structural maintenance of chromosome 1 (SMC1) is a subunit of the cohesion protein complex.
Morphology and distribution of antennal sensilla of female Phyllotreta striolata (Fabricius) (Coleoptera: Chrysomelidae).
Li et al., Jingzhou, China. In Microsc Res Tech, Feb 2016
Five types of sensilla were identified, including sensilla cheaetica, sensilla trichodea, Böhm bristles, sensilla auricillica, and sensilla basiconica (five subtypes, SB1-SB2).
Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis.
Wagner et al., Boston, United States. In J Thromb Haemost, Jan 2016
METHODS: We performed in vitro NET assays using neutrophils from wild-type (WT), NE(-/-) , SerpinB1 (SB1(-/-) ), and NE(-/-) SB1(-/-) mice.
Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and Other Microbial Community Members in Biogeochemical Transformations in Oil Reservoirs.
Banfield et al., Berkeley, United States. In Mbio, Dec 2015
The greatest numbers of candidate phyla were recovered from the mesothermic reservoir samples SB1 and SB2.
(In)Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study.
Saunders et al., São Paulo, Brazil. In Plos One, 2014
Blood lactate was elevated following exercise in all trials (p ≤ 0.001), and was higher in some, but not all, SB trials compared to PL. TWD was not significantly improved with SB vs. PL in any trial (SB1: +3.6%; SB2 +0.3%; SB3: +2.1%; SB4: +6.7%; all p > 0.05), although magnitude-based inferences suggested a 93% likely improvement in SB4.
Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming.
Hu et al., Shanghai, China. In Cell Stem Cell, 2013
Knockdown of the cohesin-complex gene SMC1 by RNAi abolished the intrachromosomal interaction and affected pluripotency.
Cohesin complexes with a potential to link mammalian meiosis to cancer.
Strunnikov, Guangzhou, China. In Cell Regen (lond), 2012
The first reports characterizing the SMC1 and RAD21 genes, encoding subunits of cohesin, were published 20 years ago; however the exact molecular mechanics of cohesin molecular machine in vivo remains rather obscure notwithstanding ample elegant experiments.
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Shirahige et al., Philadelphia, United States. In Nature, 2012
Cornelia de Lange syndrome (CdLS) is a dominantly inherited congenital malformation disorder, caused by mutations in the cohesin-loading protein NIPBL for nearly 60% of individuals with classical CdLS, and by mutations in the core cohesin components SMC1A (~5%) and SMC3 (<1%) for a smaller fraction of probands.
Cohesin's concatenation of sister DNAs maintains their intertwining.
Nasmyth et al., Oxford, United Kingdom. In Mol Cell, 2011
by retarding Topo II-driven decatenation, cohesin (Smc1, Smc3, Scc1) mediates sister chromatid cohesion by an indirect mechanism as well as one involving entrapment of sister DNAs inside its tripartite ring
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Lavin et al., Brisbane, Australia. In J Biol Chem, 2011
phosphorylation of Rad50 plays a key regulatory role as an adaptor for specific ATM-dependent downstream signaling through SMC1 for DNA repair and cell cycle checkpoint control in the maintenance of genome integrity.
Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage.
Wang et al., Jena, Germany. In Mech Ageing Dev, 2011
Point mutation at the Nbs1 Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage.
Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae.
Yu et al., Tallahassee, United States. In Genetics, 2011
Scc3 and Smc1 are both required for the production of the meiosis-specific subunit Rec8.
RPGR: role in the photoreceptor cilium, human retinal disease, and gene therapy.
Stieger et al., Gießen, Germany. In Ophthalmic Genet, 2011
The Retinitis Pigmentosa GTPase Regulator (RPGR), which is located in the CC, participates in the IFT and interacts with a variety of proteins, including RPGRIP-1, CEP290, NPM, SMC1 and 3 and IFT88.
A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion.
Nasmyth et al., Oxford, United Kingdom. In Embo J, 2011
A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion.
An update on cohesin function as a 'molecular glue' on chromosomes and spindles.
Wong, Kanazawa, Japan. In Cell Cycle, 2010
This review summarizes recent progress in understanding the functions of cohesin, and of its major subunits, SMC1, SMC3, Scc1 and Scc3.
Cohesinopathies: One ring, many obligations.
Gerton et al., Kansas City, United States. In Mutat Res, 2009
In the past 4 years, genetic studies of patients have revealed the primary genes involved in these disorders are the essential, evolutionarily conserved components of the cohesin pathway.
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.
Petrini et al., New York City, United States. In Nature, 2007
Instead, the defects observed in Nbs1(DeltaC/DeltaC) result from impaired phosphorylation of ATM targets including SMC1 and the proapoptotic factor, BID.
X-linked Cornelia de Lange syndrome owing to SMC1L1 mutations.
Larizza et al., Segrate, Italy. In Nat Genet, 2006
mutations in SMC1L1 (also known as SMC1), which encodes a different subunit of the cohesin complex, are responsible for Cornelia de Lange syndrome in three male members of an affected family and in one sporadic case
Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis.
McKee et al., Knoxville, United States. In Cell, 2005
SNM and MNM do not colocalize with SMC1, suggesting that the homolog conjunction mechanism is independent of cohesin.
The ATM-dependent DNA damage signaling pathway.
Kastan et al., Memphis, United States. In Cold Spring Harb Symp Quant Biol, 2004
The SMC1 protein appears to be a particularly important target of the ATM kinase, playing critical roles in controlling DNA replication forks and DNA repair after the damage.
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