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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3

SMARCD3, Baf60c
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, BRG1, CAN, HOS, GATA4
Papers on SMARCD3
Generation of Functional Human Cardiac Progenitor Cells by High-Efficiency Protein Transduction.
Yu et al., Detroit, United States. In Stem Cells Transl Med, Dec 2015
This reprogramming process enriched trimethylated histone H3 lysine 4, monoacetylated histone H3 lysine 9, and Baf60c at the Nkx2.5 cardiac enhancer region by the chromatin immunoprecipitation quantitative polymerase chain reaction assay.
ETS-related transcription factors ETV4 and ETV5 are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
Yokota et al., Kanazawa, Japan. In J Biol Chem, Oct 2015
Microarray analysis demonstrated that stem cell-related genes, including Tcf15, Gbx2, Lrh1, Zic3, and Baf60c, were significantly repressed in Etv4/5 dKO ES cells.
Gata4, Tbx5 and Baf60c induce differentiation of adipose tissue-derived mesenchymal stem cells into beating cardiomyocytes.
Li et al., Xinxiang, China. In Int J Biochem Cell Biol, Sep 2015
In this study we have shown that the combination of Gata4, Tbx5 and Baf60c is sufficient for inducing ADMSCs to form cardiomyocytes.
Postmitotic Expression of SOD1(G93A) Gene Affects the Identity of Myogenic Cells and Inhibits Myoblasts Differentiation.
Musarò et al., Roma, Italy. In Mediators Inflamm, 2014
Expression of MLC/SOD1(G93A) in C2C12 myogenic cells promoted a fibro-adipogenic progenitors (FAPs) phenotype, upregulating HDAC4 protein and preventing the myogenic commitment complex BAF60C-SWI/SNF.
Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes.
Kere et al., Stockholm, Sweden. In Clin Epigenetics, 2014
CONCLUSIONS: This study reveals that susceptibility loci for complex inflammatory diseases (for example, IRF5, NOD2, and PTGER4) and genes encoding histone modifiers and chromatin remodeling factors (for example, HDAC4, KDM2A, KDM2B, JARID2, ARID3A, and SMARCD3) undergo DNA methylation changes in leukocytes during early childhood.
Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation.
Ambrogi et al., Milano, Italy. In Ai Zheng, 2014
The results indicated that, compared to bipotent cells, differentiated myoepithelial and luminal subpopulations were both characterized by the differential expression of 4 genes involved in cell identity maintenance: CBX6 and PCGF2, encoding proteins belonging to the Polycomb group, and SMARCD3 and SMARCE1, encoding proteins belonging to the Trithorax group.
myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis.
Münsterberg et al., Norwich, United Kingdom. In Development, 2014
BAF60a, BAF60b and BAF60c are structural subunits of the BAF complex that bind to the core ATPase Brg1 to provide functional specificity.
Targeted inactivation of Cerberus like-2 leads to left ventricular cardiac hyperplasia and systolic dysfunction in the mouse.
Belo et al., Faro, Portugal. In Plos One, 2013
Concomitantly, we detected an increase of Baf60c levels, but only in Cerl2-/- embryonic hearts.
Generation of myospheres from hESCs by epigenetic reprogramming.
Puri et al., Santa Lucía, Spain. In J Vis Exp, 2013
We have designed a protocol that overcomes these limits by ectopic introduction of defined factors in hESCs--the muscle determination factor MyoD and SWI/SNF chromatin remodeling complex component BAF60C--that are able to reprogram hESCs into skeletal muscle cells.
Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation.
Lin et al., Ann Arbor, United States. In Nat Med, 2013
Here we show that Baf60c (also called Smarcd3), a transcriptional cofactor enriched in fast-twitch muscle, promotes a switch from oxidative to glycolytic myofiber type through DEP domain-containing mTOR-interacting protein (Deptor)-mediated Akt activation.
BAF60 A, B, and Cs of muscle determination and renewal.
Mercola et al., Los Angeles, United States. In Genes Dev, 2013
A key component of the code appears to be the mutually exclusive usage of the a, b, and c variants of the 60-kD structural subunit BAF60 (BRG1/BRM-associated factor 60), of which BAF60c is essential to activate both skeletal and cardiac muscle programs.
[Morphological and molecular bases of cardiac development].
Burdan et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2012
Their expression is regulated by various molecules, including transcription (XIN, GATA, MEF, Tbx5, Baf60c, PECAM, tie-2, MEF2) and growth (VEGF, FGF, PDGF) factors, as well as proteins (i.e., dickkopf-1, cerberus, cytotactin, fibrillin, nodal, thrombomodulin, Wnt, bone morphometric ones - BMP2, BMP 4, BMP5, BMP7) and other substances, such as retinoid and folic acid.
Signal-dependent incorporation of MyoD-BAF60c into Brg1-based SWI/SNF chromatin-remodelling complex.
Puri et al., Los Angeles, United States. In Embo J, 2012
BAF60c phosphorylation on a conserved threonine is the signal that promotes incorporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes.
Epigenetic mechanisms in cardiac development and disease.
Wu et al., Boston, United States. In Acta Biochim Biophys Sin (shanghai), 2012
We provide examples of how several cardiac TFs, such as Nkx2.5, WHSC1, Tbx5, and Tbx1, which are associated with developmental and congenital heart defects, are required for the recruitment of histone modifiers, such as Jarid2, p300, and Ash2l, and components of ATP-dependent remodeling enzymes like Brg1, Baf60c, and Baf180.
Directed differentiation of human embryonic stem cells to interrogate the cardiac gene regulatory network.
Denning et al., Nottingham, United Kingdom. In Mol Ther, 2011
GTNB directs cardiogenesis from human embryonic stem cells and induces correct cardiac development.
Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors.
Bruneau et al., San Francisco, United States. In Nature, 2009
We show that two cardiac transcription factors, Gata4 and Tbx5, and a cardiac-specific subunit of BAF chromatin-remodelling complexes, Baf60c (also called Smarcd3), can direct ectopic differentiation of mouse mesoderm into beating cardiomyocytes, including the normally non-cardiogenic posterior mesoderm and the extraembryonic mesoderm of the amnion.
Baf60c is a component of the neural progenitor-specific BAF complex in developing retina.
Reh et al., Seattle, United States. In Dev Dyn, 2008
Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage
The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.
Lefebvre et al., Lille, France. In Mol Cell Endocrinol, 2007
Two highly related subunits of the core SWI/SNF complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for retinoic acid receptors.
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
Bruneau et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2007
propose a critical role for Baf60c in Notch-dependent transcription and left-right asymmetry
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
Bruneau et al., Toronto, Canada. In Nature, 2004
Smarcd3, encoding Baf60c, a subunit of the BAF complexes, is expressed specifically in the heart and somites in the early mouse embryo
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