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Small EDRK-rich factor 1A

SMAM-1, 4F5, H4F5, SERF1A
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, SmaI, NAIP, HAD
Papers on SMAM-1
Joint effect of the SMN2 and SERF1A genes on childhood-onset types of spinal muscular atrophy in Serbian patients.
Savić-Pavićević et al., Belgrade, Serbia. In J Hum Genet, Nov 2015
Multiplex ligation-dependent probe amplification (MLPA) was used to construct 5q13.2 alleles and assess copy number of the SMN2, small EDRK-rich factor 1A (SERF1A) and NLR family apoptosis inhibitory protein (NAIP) genes in 99 Serbian patients with SMN1 homozygous absence (23-type I, 37-type II and 39-mild type III) and 122 patients' parents.
Temperature sensor based on ladder-level assisted thermal coupling and thermal-enhanced luminescence in NaYF4: Nd³⁺.
Yin et al., In Opt Express, 2015
The bands of near-infrared (NIR) luminescence originating from the 4F3/2, 4F5/2 and 4F7/2 levels of Nd³⁺ ions in NaYF4: Nd³⁺ microcrystals were measured under 574.8 nm excitation at various temperatures from 323 to 673 K.
Optical temperature sensing based on the near-infrared emissions from Nd³⁺/Yb³⁺ codoped CaWO₄.
Cao et al., In Opt Lett, 2014
Under a 980 nm diode laser excitation, the near-infrared (NIR) emissions from Nd3+:4F7/2, 4F5/2, and 4F3/2 states in Nd3+/Yb3+ codoped CaWO4 powder were studied at temperatures ranging from 303 to 873 K.
[Analysis and carrier screening for copy numbers of SMN and NAIP genes in children with spinal muscular atrophy].
Zhang et al., Zunyi, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2014
OBJECTIVE: To assess the association of copy number variations of SMN1, SMN2, NAIP, GTF2H2 and H4F5 genes with clinical classification of spinal muscular atrophy in children, and determine the copy number of the SMN gene among pregnant women.
Bacteria, viruses, and hypothalamic inflammation: potential new players in obesity.
Bojanowska et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2013
Other studies revealed an excessive increase in body weight in a significant percentage of people infected with human adenoviruses SMAM-1 and Ad-36.
Human 4F5 single-chain Fv antibody recognizing a conserved HA1 epitope has broad neutralizing potency against H5N1 influenza A viruses of different clades.
Jiao et al., Nanjing, China. In Antiviral Res, 2013
Using the recombinant H5N1 virus hemagglutinin ectodomain (HA1), 4F5 scFv was identified with neutralizing activity against both clade 2 and 9 H5N1 viruses.
Molecular analysis of SMN1, SMN2, NAIP, GTF2H2, and H4F5 genes in 157 Chinese patients with spinal muscular atrophy.
Chen et al., China. In Gene, 2013
In this study, we analyzed mutations in SMN1 and quantified the modifying genes, including SMN2, NAIP, GTF2H2, and H4F5 by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), multiplex ligation-dependent probe amplification (MLPA), TA cloning, allele-specific long-range PCR, and Sanger sequencing in 157 SMA patients.
Multi-phonon assisted upconversion emission and power dependence studies in LaF3:Er3+ phosphor.
Kumar et al., Benares, India. In Spectrochim Acta A Mol Biomol Spectrosc, 2013
At relatively higher excitation powers multi-phonon assisted energy migration from 2H11/2 (4S3/2) level to the upper 4F3/2, 4F5/2 and 4F7/2 levels has observed and this energy migration opened new channel of emission at 440 nm, 453 nm and 488 nm due to the 4F3/2→4I15/2, 4F5/2→4I15/2 and 4F7/2→4I15/2 transitions, respectively.
Identification of B cell epitopes of dengue virus 2 NS3 protein by monoclonal antibody.
Chen et al., Chongqing, China. In Appl Microbiol Biotechnol, 2013
Previously, a neutralizing monoclonal antibody (mAb) 4F5 against nonstructural protein 3 (NS3) of dengue virus 2 (DV2) was developed in our lab.
Correlation of SMN2, NAIP, p44, H4F5 and Occludin genes copy number with spinal muscular atrophy phenotype in Tunisian patients.
Gribaa et al., Sousse, Tunisia. In Eur J Paediatr Neurol, 2012
There is a close relationship between SMN2, NAIP and H4F5 gene copy number and spinal muscular atrophy disease severity
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.
Nollen et al., Groningen, Netherlands. In Cell, 2010
The human orthologs of MOAG-4, SERF2 and SERF1A, are ubiquitously expressed, consistent with a role in a general cellular pathway.
Viral obesity: fact or fiction?
Clarke et al., Hattiesburg, United States. In Obes Rev, 2010
Other viral agents associated with increasing obesity in animals included canine distemper virus, rous-associated virus 7, scrapie, Borna disease virus, SMAM-1 and other adenoviruses.
Infeccions as the etiology for obesity.
Bornschein et al., Curitiba, Brazil. In Arq Bras Endocrinol Metabol, 2009
Studies on humans are far less convincing; however, two adenoviruses, Ad-36 and SMAM-1, have shown adipogenic properties.
Viruses as an etiology of obesity.
Atkinson, Richmond, United States. In Mayo Clin Proc, 2007
The obesogenic animal viruses include canine distemper virus, Rous-associated virus type 7, Borna disease virus, scrapie agent, and SMAM-1.
[Obesity development associated with viral infections].
Bazylak et al., In Postepy Hig Med Dosw (online), 2005
More attention is focused on the results of preliminary epidemiological studies indicating that human infection by the avian adenovirus SMAM-1 or the human adenovirus Ad-36 can be objectively related to symptoms, prevalence, and complications of obesity in some adult men.
Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics.
Kunkel et al., Boston, United States. In Nat Genet, 1998
Using comparative genomics to screen for such a factor among evolutionarily conserved sequences between mouse and human, we have identified a novel transcript, H4F5, which lies closer to SMN1 than any previously identified gene in the region.
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