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SMAD family member 6

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009] (from NCBI)
Top mentioned proteins: Smad3, Smad4, Smad7, Smad2, Smad1
Papers using Smad6 antibodies
Characterization of connexin31.1-deficient mice reveals impaired placental development
Asashima Makoto et al., In In Vitro Cellular & Developmental Biology. Animal, 2006
... Cruz Biotechnology, Santa Cruz, CA, 1:1,000), anti-phospho Smad1/5/8 (Cell Signaling Technology, Beverly, MA, 1:1,000), and anti-Smad6 (Abcam, Cambridge, UK, 1:1,000) ...
Papers on Smad6
Bone Morphogenetic Protein-6 (BMP-6) Stimulates the Antrum Formation by the Regulation of its Signalling Pathway in Caprine Pre-antral Follicles Cultured In Vitro.
Figueiredo et al., Fortaleza, Brazil. In Reprod Domest Anim, Jan 2016
Thus, this study investigated the effect of bone morphogenetic protein (BMP-6) and recombinant follicle-stimulating hormone (rFSH) alone or in combination on the in vitro culture (IVC) of isolated caprine secondary follicles (Experiment 1) and the mRNA levels for BMP receptors/Smad signalling pathway (BMPR1A, BMPR2, SMAD1, SMAD4, SMAD5, SMAD6, SMAD7 and SMAD8) in vivo and in vitro using BMP-6 (Experiment 2).
Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis.
Wong et al., Singapore, Singapore. In J Mol Med (berl), Nov 2015
Moreover, VPA decreased Smad2, Smad3 and Smad4 but increased Smad6 expression with a similar intensity-exposure profile.
Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.
Newman et al., Çanakkale, Turkey. In Ann Rheum Dis, Jun 2015
Western blot analysis revealed markedly decreased inhibitory SMAD6 levels in patients with LP.
Inhibitory SMADs: potential regulators of ovarian function.
Li, College Station, United States. In Biol Reprod, Feb 2015
SMAD proteins are canonical TGFB signaling components consisting of receptor-regulated SMADs (SMAD1/2/3/5/9), a common SMAD (SMAD4), and inhibitory SMADs (SMAD6/7).
Genome Wide Methylome Alterations in Lung Cancer.
Spivack et al., New York City, United States. In Plos One, 2014
IPA analyses showed adenocarcinoma-specific promoter DMxDE overlay identified familiar lung cancer nodes [tP53, Akt] as well as less familiar nodes [HBEGF, NQO1, GRK5, VWF, HPGD, CDH5, CTNNAL1, PTPN13, DACH1, SMAD6, LAMA3, AR].
A Major Gene for Bovine Ovulation Rate.
Morris et al., Madison, United States. In Plos One, 2014
This region contains three candidate genes, SMAD3, SMAD6 and IQCH.
Keratoconus in vitro and the key players of the TGF-β pathway.
Karamichos et al., Oklahoma City, United States. In Mol Vis, 2014
RESULTS: We found a significant downregulation in the SMAD6 and SMAD7 expressions by HKCs when compared to HCFs (p≤0.05).
Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.
Chen et al., Shenzhen, China. In Clin Epigenetics, 2014
Analysis of an additional 78 HCC pairs on the Illumina MiSeq platform confirmed that 7 genes showed either promoter hyper-methylation (SMAD6, IFITM1, LRRC4, CHST4, and TBX15) or hypo-methylation (CCL20 and NQO1) in HCC.
Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival.
Verma et al., New York City, United States. In Clin Cancer Res, 2014
Various important underexpressed genes, such as SMAD6, were associated with aberrantly methylated, intronic enhancers, and these changes were validated in an independent cohort.
USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.
Sapkota et al., Dundee, United Kingdom. In Open Biol, 2014
SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation.
Modulators of networks: molecular targets of arterial calcification identified in man and mice.
Rutsch et al., Münster, Germany. In Curr Pharm Des, 2013
Furthermore, intracellular signaling molecules, including SMAD6 and a number of systemic circulatory inhibitors of arterial calcification, including fetuin, tumor necrosis factor receptor superfamily member 11b, matrix GLA protein, adiponectin and family with sequence similarity 20 member A have been identified by human and mouse genetics.
Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells.
Castresana et al., Pamplona, Spain. In Plos One, 2013
We focused on the aberrant activation of TGF-β and Hh signalling pathways, confirming the inhibition of repressors of TGF-β pathway, as SMAD6 and SMAD7 by RT-qPCR.
Association of lung adenocarcinoma clinical stage with gene expression pattern in noninvolved lung tissue.
Dragani et al., Milano, Italy. In Int J Cancer, 2012
Loss of SMAD6 is associated with lung adenocarcinoma.
Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells.
Mamura et al., Inch'ŏn, South Korea. In Biochem Biophys Res Commun, 2012
Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Pin1 protein regulates Smad protein signaling and pulmonary fibrosis.
Malter et al., Madison, United States. In J Biol Chem, 2012
Results indicate that peptidyl-prolyl isomerase Pin1 Associates with Smad3 and Smad6.
Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation.
Keavney et al., Newcastle upon Tyne, United Kingdom. In Hum Mutat, 2012
Congenital cardiovascular malformation is related to genetic variation in SMAD6
Genetic variants in TGF-β pathway are associated with ovarian cancer risk.
Liang et al., Houston, United States. In Plos One, 2010
Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.
Bone morphogenetic protein-7 (BMP7) in chronic kidney disease.
Hirschberg et al., Torrance, United States. In Front Biosci, 2007
These antifibrogenic activities result from inhibition of the nuclear translocation of TGFbeta-activated smad3 by smad6 downstream of BMP7-activated smad5.
Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy.
Sane et al., Winston-Salem, United States. In Med Res Rev, 2001
Animals lacking MGP, OPG, smad6, carbonic anhydrase isoenzyme II, fibrillin-1, and klotho gene product develop varying extents of arterial calcification.
A role for smad6 in development and homeostasis of the cardiovascular system.
Huszar et al., Cambridge, United States. In Nat Genet, 2000
Here we explore the role of an inhibitory Smad in vivo by targeted mutation of Madh6 (which encodes the Smad6 protein).
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