Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis
In PLoS ONE, 2003
... NS4A, TGF-β1 (Chemicon, Temecula, CA), Phospho-Smad2, Phospho-Smad3, Smad2, Smad3, Phospho-P38, P-38, Phospho-JNK, JNK, vimentin and Slug (Cell Signaling, Danvers, MA), TGF-β receptor ...
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.
Cambridge, United States. In Nature, Oct 2015
Supporting this notion, we and others previously established that the Slug epithelial-to-mesenchymal transition-inducing transcription factor (EMT-TF), a member of the Snail family, serves as a master regulator of the gland-reconstituting activity of normal mammary stem cells, and that forced expression of Slug in collaboration with Sox9 in breast cancer cells can efficiently induce entrance into the TIC state.
Multifaceted roles of HSF1 in cancer.
Chengdu, China. In Tumour Biol, Jul 2015
Third, HSF1 serves as a regulator of different signaling pathways, such as HuR-HIF-1, Slug, protein kinase C (PKC), nuclear factor-kappaB (NF-κB), PI3K-AKT-mTOR, and mitogen-activated protein kinase (MAPK) pathways.