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SLIT and NTRK-like family, member 6

Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003 [PubMed 14557068]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: SLITRK1, trkA, CAN, AGE, SET
Papers on Slitrk6
Deafness and Myopia Syndrome
Tekin et al., Seattle, United States. In Unknown Journal, Feb 2015
DIAGNOSIS/TESTING: Identification of biallelic pathogenic variants in SLITRK6 confirms the diagnosis of DFNMYP syndrome.
Molecular Analysis of Upper Tract and Bladder Urothelial Carcinoma: Results from a Microarray Comparison.
Meng et al., San Francisco, United States. In Plos One, 2014
One of the genes most highly expressed in upper tract tumors, SLITRK6, is the target of an antibody drug conjugate (AGS15E) currently in phase I clinical trials.
Differential changes in gene expression in human brain during late first trimester and early second trimester of pregnancy.
Shah et al., Madison, United States. In Prenat Diagn, 2014
Also, SLITRK6-HAS2 and CRYAB-PCDH18 genes for ear and eye sensory input were upregulated in B1.
A homozygous SLITRK6 nonsense mutation is associated with progressive auditory neuropathy in humans.
Strauss et al., Wilmington, United States. In Laryngoscope, 2014
In mice, Slitrk6 plays a role in the survival and innervation of sensory neurons in the inner ear, vestibular apparatus, and retina, and also influences axial eye length.
Transcriptional profiling of adult neural stem-like cells from the human brain.
Langmoen et al., Oslo, Norway. In Plos One, 2013
The NGFR, SLITRK6 and KCNS3 receptors were further investigated by immunofluorescence and shown to be heterogeneously expressed in spheres.
SLITRK6 mutations cause myopia and deafness in humans and mice.
Crosby et al., Miami, United States. In J Clin Invest, 2013
Our molecular investigation in 3 families led to the identification of 3 homozygous nonsense mutations (p.R181X, p.S297X, and p.Q414X) in SLIT and NTRK-like family, member 6 (SLITRK6), a leucine-rich repeat domain transmembrane protein.
Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder.
Kelsoe et al., San Diego, United States. In Plos One, 2012
This broad peak is in a relative gene desert over an unknown EST and between the SLITRK1 and SLITRK6 genes.
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice.
Zitzelsberger et al., M√ľnchen, Germany. In Endocr Relat Cancer, 2012
DNA losses of SLITRK1 and SLITRK5 were observed in 21% of cases and of SLITRK6 in 16% of cases.
Region-specific gene expression in early postnatal mouse thalamus.
Shimogori et al., Saitama, Japan. In J Comp Neurol, 2011
We first demonstrated the selective expression of neurotransmitter-related genes (vGlut2, vGAT, D2R, and HTR2C), identifying the neurotransmitter subtypes of cells in this region, and we also demonstrated selective expression of additional genes in the thalamus (Steel, Slitrk6, and AI852580).
Impaired auditory-vestibular functions and behavioral abnormalities of Slitrk6-deficient mice.
Aruga et al., Wako, Japan. In Plos One, 2010
the altered responses of Slitrk6-KO mice to the novel environment suggest a role of Slitrk6 in some cognitive functions.
Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.
Aruga et al., Wako, Japan. In Plos One, 2008
Slitrk6 promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia
Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3.
Aruga, Wako, Japan. In Gene Expr Patterns, 2003
Slitrk6 gene expression profile in the mouse embryo.
Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.
Mikoshiba et al., Wako, Japan. In Gene, 2003
In this paper, we characterized the human SLITRK1, SLITRK2, SLITRK3, SLITRK4, SLITRK5, and SLITRK6 genes.
Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth.
Mikoshiba et al., Wako, Japan. In Mol Cell Neurosci, 2003
More specifically, Slitrk1 expression is in the mature neurons, whereas Slitrk2 is strongly expressed in the ventricular layer, and Slitrk6 shows compartmentalized expression in diencephalon.
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