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Sialic acid binding Ig-like lectin 12

SLG, Siglec-like
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CD45, ZAP-70, ACID, HAD, CAN
Papers on SLG
Permuting the PGF-CTERM signature motif blocks both archaeosortase-dependent C-terminal cleavage and prenyl lipid attachment for the Haloferax volcanii S-layer glycoprotein.
Pohlschroder et al., Philadelphia, United States. In J Bacteriol, Jan 2016
UNASSIGNED: For years, the S-layer glycoprotein (SLG), the sole component of many archaeal cell walls, was thought to be anchored to the cell surface by a C-terminal transmembrane segment.
Absorption-enhancing effects of gemini surfactant on the intestinal absorption of poorly absorbed hydrophilic drugs including peptide and protein drugs in rats.
Yamamoto et al., Kyoto, Japan. In Int J Pharm, Jan 2016
The intestinal absorption of drugs, with or without sodium dilauramidoglutamide lysine (SLG-30), a gemini surfactant, was examined by an in situ closed-loop method in rats.
Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells.
Wang et al., Wuhan, China. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
The analog of diacylglycerol (DAG; another endogenous signaling molecule), 1-oleyl-2-acetyl-sn-glycerol (OAG), 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG), and 1-stearoyl-2-linoleoyl-sn-glycerol (SLG) all augment NSCC activity.
Pulsatile Hyperglycaemia Induces Vascular Oxidative Stress and GLUT 1 Expression More Potently than Sustained Hyperglycaemia in Rats on High Fat Diet.
Raun et al., Copenhagen, Denmark. In Plos One, Dec 2015
METHODS: Animals were infused with sustained high (SHG), low (SLG), pulsatile (PLG) glucose or saline (VEH) for 96 h.
[GLP-1 receptor expression in rat major salivary glands and the effects of bilateral maxillary molar extraction on its expression].
Rieko, In Kokubyo Gakkai Zasshi, Mar 2015
The rats were sacrificed at 8 and 11 weeks old, then the parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG) were analyzed immunohistochemically for the presence of GLP-1R.
Cloning, Expression and Characterization of a Thermostable Esterase HydS14 from Actinomadura sp. Strain S14 in Pichia pastoris.
Sriyapai et al., Bangkok, Thailand. In Int J Mol Sci, 2014
The HydS14 sequence shows 46%-64% identity to 23 sequences from actinomycetes (23 α/β-hydrolases), has three conserved regions, and contains the novel motif (GY(F)SLG), which distinguishes it from other clusters in the α/β-hydrolase structural superfamily.
A simple technique to improve the resolution of membrane acidic proteins of the haloarchaeon Haloferax volcanii by 2D electrophoresis.
Cesari et al., Mar del Plata, Argentina. In Electrophoresis, 2014
Due to the abundance of the S-layer glycoprotein (SLG) in membrane protein extracts, other proteins from the envelope are consequently underrepresented.
Maintenance of Chronic Fatigue Syndrome (CFS) in Young CFS Patients Is Associated with the 5-HTTLPR and SNP rs25531 A > G Genotype.
Gjerstad et al., Oslo, Norway. In Plos One, 2014
Patients with the 5-HTT SS or SLG genotype had a significantly lower number of steps per day than patients with the 5-HTT LALG, SLA or LALA genotype.
Glyoxalase II promotes "in vitro" S-glutathionylation.
Armeni et al., Ancona, Italy. In Free Radic Biol Med, 2014
These studies, revealed that GloII, using its natural substrate SLG, allow a rapid and specific protein-SSG formation, leading enzymatic regulation of S-glutathionylation in proteins of different origin and cellular compartmentalization.
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
Varki et al., San Diego, United States. In J Biol Chem, 2011
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas.
Self-organization and pattern formation in primate cortical networks.
Dehay et al., Bron, France. In Novartis Found Symp, 2006
The interareal connectivity of the neurons in the SLG largely determines the cortical hierarchy that constrains information flow through the cortex.
Just how complex is the Brassica S-receptor complex?
Doughty et al., Bath, United Kingdom. In J Exp Bot, 2003
The role of accessory molecules, in particular SLG (S-locus glycoprotein) and low molecular weight pollen coat proteins (PCPs), in pollination are discussed, as is the link between SI and unilateral incompatibility (UI).
Molecular mechanism of self-recognition in Brassica self-incompatibility.
Isogai et al., Ikoma, Japan. In J Exp Bot, 2003
In Brassica, genetic dissection of the S-locus has revealed the presence of three highly-polymorphic genes: S-receptor kinase (SRK), S-locus protein 11 (SP11) (also known as S-locus cysteine-rich protein; SCR) and S-locus glycoprotein (SLG).
Direct ligand-receptor complex interaction controls Brassica self-incompatibility.
Isogai et al., Ikoma, Japan. In Nature, 2001
In Brassica self-incompatibility, recognition between pollen and the stigma is controlled by the S locus, which contains three highly polymorphic genes: S-receptor kinase (SRK), S-locus protein 11 (SP11) (also called S-locus cysteine-rich protein; SCR) and S-locus glycoprotein (SLG).
Molecular mechanisms of self-incompatibility in Brassica.
Curn et al., České Budějovice, Czech Republic. In Curr Issues Mol Biol, 2000
The role of the S locus glycoprotein (SLG) gene remains unclear.
The S receptor kinase determines self-incompatibility in Brassica stigma.
Hinata et al., Sendai, Japan. In Nature, 2000
Two tightly linked polymorphic genes at the S locus, S receptor kinase gene (SRK) and S locus glycoprotein gene (SLG), are specifically expressed in the papillar cells of the stigma, and analyses of self-compatible lines of Brassica have suggested that together they control stigma function in self-incompatibility interactions.
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