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Solute carrier family 26, member 6

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRA, Cystic Fibrosis Transmembrane Conductance Regulator, ACID, V1a, PGD2
Papers on SLC26A6
Adjustments of molecular key components of branchial ion and pH regulation in Atlantic cod (Gadus morhua) in response to ocean acidification and warming.
Lucassen et al., Bremerhaven, Germany. In Comp Biochem Physiol B Biochem Mol Biol, Mar 2016
Here, we characterized the regulation of transepithelial ion transporters (NKCC1, NBC1, SLC26A6, NHE1 and 2) and ATPases (Na(+)/K(+) ATPase and V-type H(+) ATPase) in gills of Atlantic cod (Gadus morhua) after 4weeks of exposure to ambient and future PCO2 levels (550μatm, 1200μatm, 2200μatm) at optimum (10°C) and summer maximum temperature (18°C), respectively.
Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.
Hungarian Pancreatic Study Group et al., Szeged, Hungary. In Pancreatology, Sep 2015
BACKGROUND: Pancreatic ductal HCO3(-) secretion is critically dependent on the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and the solute-linked carrier 26 member 6 anion transporter (SLC26A6).
The differential role of renoguanylin in osmoregulation and apical Cl-/HCO3- exchange activity in the posterior intestine of the Gulf toadfish (Opsanus beta).
Grosell et al., Kashiwa, Japan. In Am J Physiol Regul Integr Comp Physiol, Sep 2015
In contrast, RGN does not alter Cl(-) flux and, instead, elevates HCO3(-) secretion in the 60-ppt group, suggesting increased apical Cl(-)/HCO3(-) exchange activity by SLC26a6.
Bicarbonate exchangers SLC26A3 and SLC26A6 are localized at the apical membrane of porcine vas deferens epithelium.
Schultz et al., Manhattan, United States. In Physiol Rep, Apr 2015
The goal of this study was to test for expression of HCO3 (-) exchangers SLC26A3 and SLC26A6 in primary cultures of porcine vas deferens epithelial cells (1°PVD) and native porcine vas deferens.
Mechanisms of Cl(-) uptake in rainbow trout: cloning and expression of slc26a6, a prospective Cl(-)/HCO3(-) exchanger.
Goss et al., Edmonton, Canada. In Comp Biochem Physiol A Mol Integr Physiol, Feb 2015
The objectives of the present study were to clone slc26a6, a prospective Cl(-)/HCO3(-) exchanger from rainbow trout, investigate its expression patterns in various tissues, at different developmental stages and after differential salinity exposure, and probe the mechanisms of Cl(-) uptake in rainbow trout embryos during development using a pharmacological inhibitor approach combined with (36)Cl(-) unidirectional fluxes.
Transcriptomic Analysis of Trout Gill Ionocytes in Fresh Water and Sea Water Using Laser Capture Microdissection Combined with Microarray Analysis.
Fautrel et al., Rennes, France. In Plos One, 2014
Among them, several ion transporters, such as CIC2, SLC26A6, and NBC, were validated by qPCR and/or in situ hybridization.
Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy.
Camargo et al., São Paulo, Brazil. In Oncotarget, 2014
We identified 48 genes not previously described as mutated in colorectal tumors in the TCGA database, including genes that are mutated and expressed in >10% of the cell lines (SEMA4C, FGFRL1, PKD1, FAM38A, WDR81, TMEM136, SLC36A1, SLC26A6, IGFLR1).
Mechanism and synergism in epithelial fluid and electrolyte secretion.
Muallem et al., Bethesda, United States. In Pflugers Arch, 2014
Ductal fluid and HCO3 (-) secretion are mediated by the basolateral membrane Na(+)-HCO3 (-) cotransporter NBCe1-B and the luminal membrane Cl(-)/HCO3 (-) exchanger slc26a6 and the Cl(-) channel CFTR.
SLC26 anion exchangers in uterine epithelial cells and spermatozoa: clues from the past and hints to the future.
Sun et al., Hong Kong, Hong Kong. In Cell Biol Int, 2014
The solute carrier 26 (SLC26) family emerges as a distinct class of anion transporters with its members SLC26A3 (Slc26a3) and SLC26A6 (Slc26a6) reported to be electrogenic Cl(-)/HCO3(-) exchangers.
Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx.
Zhang et al., Hohhot, China. In Sci Rep, 2013
This chloride ion loss was significantly prevented by L. casei via upregulating of chloride ion-dependent genes (ClC1-7, GlyRα1, SLC26A3, SLC26A6, GABAAα1, Bestrophin-3 and CFTR).
Oxalate: from the environment to kidney stones.
Sabolić et al., In Arh Hig Rada Toksikol, 2013
Two members of this family [Sulfate Anion Transporter 1 (SAT-1; SLC26A1) and Chloride/Formate EXchanger (CFEX; SLC26A6)] may contribute to oxalate transport in the intestine, liver, and kidneys.
Physiology and pathophysiology of bicarbonate secretion by pancreatic duct epithelium.
Mochimaru et al., Nagoya, Japan. In Nagoya J Med Sci, 2012
In the proximal part of pancreatic ducts close to acinar cells HCO3 secretion across the apical membrane is largely mediated by SLC26A6 CI- -HCO3- exchanger.
Functional activity of Pat-1 (Slc26a6) Cl(−)/HCO₃(−) exchange in the lower villus epithelium of murine duodenum.
Clarke et al., Columbia, United States. In Acta Physiol (oxf), 2011
Data demonstrate functional Pat-1 Cl)/HCO3) exchange activity in the lower villus epithelium of the murine duodenum which, in previous studies, had been obscured by the inclusion of luminal glucose as a metabolic substrate.
Role of SLC26A6-mediated Cl⁻-oxalate exchange in renal physiology and pathophysiology.
Aronson, New Haven, United States. In J Nephrol, 2010
Subsequent studies identified anion transporter SLC26A6 as responsible for proximal tubule Cl⁻-oxalate exchange activity.
Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium.
Clarke et al., Columbia, United States. In Am J Physiol Gastrointest Liver Physiol, 2010
study concludes Pat-1 Cl(-)/HCO(3)(-) exchange contributes to pH(i) regulation in the duodenal villous epithelium during H(+)-dipeptide absorption, possibly by providing a HCO(3)(-) import pathway
The switch of intestinal Slc26 exchangers from anion absorptive to HCOFormula secretory mode is dependent on CFTR anion channel function.
Seidler et al., Hannover, Germany. In Am J Physiol Cell Physiol, 2010
This study showed a functionally active CFTR is an absolute requirement for Slc26-mediated duodenal bicarbonate secretion, but not for Slc26-mediated fluid absorption.
Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange.
Dudeja et al., Chicago, United States. In Am J Physiol Gastrointest Liver Physiol, 2010
lysophosphatidic acid stimulates apical Cl(-)/OH(-) exchange activity and surface levels of SCL26A3 and SCL26A6 in intestinal epithelial cells
Parsing apical oxalate exchange in Caco-2BBe1 monolayers: siRNA knockdown of SLC26A6 reveals the role and properties of PAT-1.
Hatch et al., Gainesville, United States. In Am J Physiol Gastrointest Liver Physiol, 2009
In the intestinal epithelium, PAT-1 (SLC26A6) could mediate apical oxalate influx or apical oxalate efflux depending on the magnitude and direction prevailing counterion driver gradients as well as the relative affinities of the transported anions.
Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6.
Aronson et al., New Haven, United States. In Nat Genet, 2006
SLC26A6 is an anion exchanger expressed on the apical membrane in many epithelial tissues, including kidney and intestine.
Gating of CFTR by the STAS domain of SLC26 transporters.
Muallem et al., Dallas, United States. In Nat Cell Biol, 2004
We report here a reciprocal regulatory interaction between the SLC26T DRA, SLC26A6 and CFTR.
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