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Solute carrier family 16, member 12

This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: AGE, CAN, Nkx2.5, Nse1, IMMP2L
Papers on SLC16A12
Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria.
Fuster et al., Bern, Switzerland. In J Am Soc Nephrol, Oct 2015
UNASSIGNED: A heterozygous mutation (c.643C>A; p.Q215X) in the monocarboxylate transporter 12-encoding gene MCT12 (also known as SLC16A12) that mediates creatine transport was recently identified as the cause of a syndrome with juvenile cataracts, microcornea, and glucosuria in a single family.
Prevalence of chromosomal rearrangements involving non-ETS genes in prostate cancer.
Minner et al., Hamburg, Germany. In Int J Oncol, Apr 2015
One rearranged tumor sample was observed for each of VCL, ZNF578, IMMP2L, SLC16A12, PANK1, GPHN, LRP1 and ZHX2.
Examination of whole blood DNA methylation as a potential risk marker for gastric cancer.
Issa et al., Philadelphia, United States. In Cancer Prev Res (phila), 2013
Bisulfite pyrosequencing was used to quantify the methylation of 14 CpG island promoters (MINT25, RORA, GDNF, CDH1, RARAB2, ER, CDH13, MYOD1, SFRP1, P2RX7, SLC16A12, IGF2, DPYS, and N33) and LINE1 from 72 patients with gastric cancer, 67 control, and 52 healthy young individuals.
The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter.
Kloeckener-Gruissem et al., Zürich, Switzerland. In Hum Mol Genet, 2013
Here, we identified a second creatine transporter (CRT2) known as monocarboxylate transporter 12 (MCT12), encoded by the cataract and glucosuria associated gene SLC16A12.
Interferon induced IFIT family genes in host antiviral defense.
Jiang et al., Pullman, United States. In Int J Biol Sci, 2012
Regardless of species, IFIT5 is always adjacent to SLC16A12.
Gene expression and miR profiles of human corneal fibroblasts in response to dexamethasone.
Wallace et al., Birmingham, United Kingdom. In Invest Ophthalmol Vis Sci, 2011
Real-time PCR confirmed upregulation of six genes, including oculocutaneous albinism II (OCA2), angiopoietin-like 7 (ANGPTL7), neuron navigator 2 (NAV2), neurofilament light chain polypeptide (NEFL), solute carrier family 16/member 12 (SLC16A12), and serum amyloid A1 (SAA1).
Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.
Philp et al., Philadelphia, United States. In Invest Ophthalmol Vis Sci, 2011
PURPOSE: SLC16A12 encodes an orphan member of the monocarboxylate transporter family, MCT12.
Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters.
Fredriksson et al., Uppsala, Sweden. In Gene, 2011
Here we study 14 of these recently discovered SLC genes (HIAT1, HIATL1, MFSD1, MFSD5, MFSD6, MFSD9, MFSD10, SLC7A14, SLC7A15, SLC10A6, SLC15A5, SLC16A12, SLC30A10 and SLC21A21) with the purpose to give much better picture over the sequence relationship and tissue expression of the diverse SLC gene family.
Biomarkers in prostate cancer epidemiology.
Verma et al., Rockville, United States. In Cancers (basel), 2010
Among epigenetic biomarkers, most reports indicate GSTP1 hypermethylation as the diagnostic marker for prostate cancer; however, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS, and NSE1 also have been reported to be regulated by methylation mechanisms in prostate cancer.
Alterations of the 5'untranslated region of SLC16A12 lead to age-related cataract.
Kloeckener-Gruissem et al., Zürich, Switzerland. In Invest Ophthalmol Vis Sci, 2010
The monocarboxylate transporter SLC16A12 may contribute to age-related cataract. Sequences within the 5'UTR modulate translational efficiency with pathogenic consequences.
Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria.
Berger et al., Zürich, Switzerland. In Am J Hum Genet, 2008
SLC16A12 is important for lens and kidney homeostasis; its potential role in age-related cataract is discussed.
Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling.
Issa et al., Houston, United States. In Plos One, 2007
Based on methylation in primary tumors compared to normal adjacent tissues, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS and NSE1 are candidate biomarkers for prostate cancer (methylation range 50%-85%).
Transient multiple acyl-CoA dehydrogenation deficiency in a newborn female caused by maternal riboflavin deficiency.
Christodoulou et al., Sydney, Australia. In Mol Genet Metab, 2007
Sequencing of the SLC16A12, RFK and FLAD1 genes encoding key enzymes in riboflavin transport of metabolism in the mother did not identify any pathogenic mutations.
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