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Stem-loop binding protein

This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, PCNA, ACID, caspase-3
Papers on SLBP
A multiprotein occupancy map of the mRNP on the 3' end of histone mRNAs.
Whitfield et al., United States. In Rna, Nov 2015
This SL structure interacts with the stem-loop binding protein (SLBP), which is involved in all aspects of RD-histone mRNA metabolism.
A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA.
Costa et al., New York City, United States. In Biol Trace Elem Res, Jul 2015
This stem-loop structure is the binding site for the stem-loop binding protein (SLBP), a protein involved in canonical histone mRNA processing.
Structure-specific nucleic acid recognition by L-motifs and their diverse roles in expression and regulation of the genome.
Thapar, Houston, United States. In Biochim Biophys Acta, Jun 2015
Here, I define the L-motif super-family that consists of DNA-binding HMG-box proteins and the L-motif of the histone mRNA binding domain of stem-loop binding protein (SLBP).
Thyroid hormone increases bulk histones expression by enhancing translational efficiency.
Aranda et al., Madrid, Spain. In Mol Endocrinol, 2015
Replication-dependent histone mRNAs do not contain a poly(A) tail at their 3' terminus, but instead possess a stem-loop motif, the binding site for the stem-loop binding protein (SLBP), which regulates mRNA processing, stability, and relocation to polysomes.
Report of a patient and further clinical and molecular characterization of interstitial 4p16.3 microduplication.
Di Giacomo et al., San Giovanni Rotondo, Italy. In Mol Cytogenet, 2014
The duplication includes the complete coding sequence of FAM53A, SLBP, TMEM129 and TACC3 genes and the first exon of the FGFR3 gene.
Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar, Houston, United States. In Biomolecules, 2014
Pin1 also binds several RNA binding proteins such as AUF1, KSRP, HuR, and SLBP that regulate mRNA decay by remodeling mRNP complexes.
Arsenic induces polyadenylation of canonical histone mRNA by down-regulating stem-loop-binding protein gene expression.
Costa et al., Jiddah, Saudi Arabia. In J Biol Chem, 2014
Stem-loop-binding protein (SLBP) binds the stem-loop and regulates canonical histone mRNA metabolism.
Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish.
Masai et al., Okinawa, Japan. In Dev Biol, 2014
In this study, we found that retinal neurogenesis is severely delayed in the zebrafish stem-loop binding protein (slbp) mutant.
The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA.
Kim et al., Seoul, South Korea. In Nucleic Acids Res, 2014
Here, we investigate remodeling of stem-loop binding protein (SLBP)-containing histone mRNPs occurring during the switch from the actively translating mode to the degradation mode.
Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation.
Hall et al., New York City, United States. In Proc Natl Acad Sci U S A, 2014
The minimal RNA-processing domain of SLBP is phosphorylated at an internal threonine, and Drosophila SLBP (dSLBP) also is phosphorylated at four serines in its 18-aa C-terminal tail.
Developmentally regulated elimination of damaged nuclei involves a Chk2-dependent mechanism of mRNA nuclear retention.
Lécuyer et al., Montréal, Canada. In Dev Cell, 2014
For histone messages, we show that nuclear retention involves Chk2-mediated inactivation of the Drosophila stem loop binding protein (SLBP), the levels of which are specifically depleted in damaged nuclei following Chk2 phosphorylation, an event that contributes to nuclear fallout.
Contribution of protein phosphorylation to binding-induced folding of the SLBP-histone mRNA complex probed by phosphorus-31 NMR.
Thapar, Chapel Hill, United States. In Febs Open Bio, 2013
Here, I use (31)P NMR to report on the chemical nature of a phosphothreonine that lies in the RNA binding domain of SLBP (stem-loop binding protein).
Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex.
Tong et al., New York City, United States. In Science, 2013
The stem-loop binding protein (SLBP) specifically recognizes the SL to regulate histone mRNA metabolism, and the 3'-5' exonuclease 3'hExo trims its 3'-end after processing.
Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome.
O'Driscoll et al., Brighton, United Kingdom. In Hum Mol Genet, 2012
haploinsufficiency of SLBP and/or WHSC2 (NELF-A) contributes to several novel cellular phenotypes of WHS.
Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization.
Thapar et al., Buffalo, United States. In Biochemistry, 2012
The nuclear magnetic resonance and kinetic studies presented here provide a framework for understanding how SLBP recognizes histone mRNA and highlight possible structural roles of phosphorylation and proline isomerization in RNA binding proteins
Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loop-binding protein during meiotic maturation in mice.
Clarke et al., Montréal, Canada. In Biol Reprod, 2010
During maturation, Slbp mRNA becomes polyadenylated and translationally activated. Proteasomal activity is required both to initiate and to sustain translational activation.
Maternally encoded stem-loop-binding protein is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways.
Clarke et al., Montréal, Canada. In Dev Biol, 2009
Maternally encoded Slbp is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways.
Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.
Duronio et al., Chapel Hill, United States. In Plos One, 2008
Slbp mutants display genomic instability, including loss of heterozygosity (LOH), increased presence of chromosome breaks, tetraploidy, and changes in position effect variegation (PEV).
Expression of metazoan replication-dependent histone genes.
Martin et al., Strasbourg, France. In Biochimie, 2005
Many factors are involved, including an RNA-binding protein called HBP, also called SLBP (for hairpin- or stem-loop-binding protein) that binds to a conserved hairpin located in the 3' UTR part of histone mRNA.
Formation of the 3' end of histone mRNA.
Marzluff et al., Chapel Hill, United States. In Gene, 1999
Cleavage requires several trans-acting factors, including a protein, the stem-loop binding protein (SLBP), which binds the 26-nucleotide sequence; and a small nuclear RNP, U7 snRNP.
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