Short-range cytokine gradients to mimic paracrine cell interactions in vitro.
Leipzig, Germany. In J Control Release, Feb 2016
Directed chemotactic migration of cells from a hematopoietic cell line (FDCPmix) and primary murine HSPC (Sca-1(+) CD150(+) CD48(-)) toward the SDF-1-laden microparticles proved functional short-range gradients in a two-dimensional and three-dimensional setting over time periods of many hours.
SAP signaling: a dual mechanism of action.
Saint Louis, United States. In Immunity, 2012
(2012) show that the adaptor protein SAP regulates both positive and negative signals through SLAM receptors to stabilize intercellular contacts.