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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Signaling lymphocytic activation molecule family member 1

SLAM, CD150, Laminins, LAMB2
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: SAP, CAN, HAD, CD46, V1a
Papers using SLAM antibodies
Biochemical and structural characterization of the human TL1A ectodomain
Steinberger Peter et al., In Journal of Immunological Methods, 2008
An der Grub (Kaumberg, Austria), CD19 mAb (BU12) from Ancell (Bayport, MN), and 41BB-L and CD150/SLAM (A12) from Biolegend (San Diego, CA) ...
Measles virus infection induces chemokine synthesis by neurons.
Unutmaz Derya, In PLoS ONE, 2002
... and their littermate controls, as well as CD150 transgenic mice crossed into Foxp3-GFP ...
Specific inhibition of paramyxovirus and myxovirus replication by oligopeptides with amino acid sequences similar to those at the N-termini of the F1 or HA2 viral polypeptides.
Rall Glenn F., In PLoS Pathogens, 1979
... IPO-3 and A12 monoclonal antibodies, which inhibit CD150 binding to MV, were purchased from AbCam (Cambridge, MA) ...
Papers on SLAM
Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation.
Miosge et al., Göttingen, Germany. In Am J Pathol, Feb 2016
The aim of this study was to investigate the role of laminins and nidogen-2 in osteoarthritis (OA) and their potential to support chondrogenic differentiation.
SLAM family receptors in normal immunity and immune pathologies.
Veillette et al., Montréal, Canada. In Curr Opin Immunol, Feb 2016
The signaling lymphocytic activation molecule (SLAM) family is a group of six receptors restricted to hematopoietic cells.
Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.
Graziani et al., Novara, Italy. In Sci Transl Med, Feb 2016
XLP-1 is caused by defects in signaling lymphocytic activation molecule (SLAM)-associated protein (SAP), an adaptor protein that modulates T cell receptor (TCR)-induced signaling.
Short-range cytokine gradients to mimic paracrine cell interactions in vitro.
Pompe et al., Leipzig, Germany. In J Control Release, Feb 2016
Directed chemotactic migration of cells from a hematopoietic cell line (FDCPmix) and primary murine HSPC (Sca-1(+) CD150(+) CD48(-)) toward the SDF-1-laden microparticles proved functional short-range gradients in a two-dimensional and three-dimensional setting over time periods of many hours.
A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1.
Sweadner et al., Boston, United States. In Elife, Jan 2016
Laminins are extracellular matrix proteins, widely expressed but also known to be important in synapse structure and plasticity.
Elotuzumab in combination with lenalidomide and dexamethasone in patients with relapsed multiple myeloma: final phase 2 results from the randomised, open-label, phase 1b-2 dose-escalation study.
1703 study investigators et al., Boston, United States. In Lancet Haematol, Dec 2015
BACKGROUND: Elotuzumab, an immunostimulatory monoclonal antibody targeting signalling lymphocytic activation molecule (SLAM) family member 7 (SLAMF7), selectively kills SLAMF7-expressing myeloma cells through direct activation and engagement of the innate immune system, and thus might have clinical benefit in the treatment of myeloma.
Bridging computational approaches to speech production: The semantic-lexical-auditory-motor model (SLAM).
Hickok et al., Irvine, United States. In Psychon Bull Rev, Aug 2015
UNASSIGNED: Speech production is studied from both psycholinguistic and motor-control perspectives, with little interaction between the approaches.
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.
Nahrendorf et al., Boston, United States. In Cell Stem Cell, Jun 2015
Here, we identify a CCR2(+)CD150(+)CD48(-) LSK hematopoietic subset as the most upstream contributor to emergency myelopoiesis after ischemic organ injury.
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
Levine et al., New York City, United States. In Cancer Cell, May 2015
Multipotent Tet2(-/-);Flt3(ITD) progenitors (LSK CD48(+)CD150(-)) propagate disease in secondary recipients and were refractory to standard AML chemotherapy and FLT3-targeted therapy.
Molecular Basis of Laminin-Integrin Interactions.
Sekiguchi et al., Suita, Japan. In Curr Top Membr, 2014
Laminins are composed of three polypeptide chains, designated as α, β, and γ.
Applying Proteomics to Investigate Extracellular Matrix in Health and Disease.
Lennon et al., Manchester, United Kingdom. In Curr Top Membr, 2014
Laminins, collagen IV, nidogens, perlecan, and type XV/XVIII collagen are integral to BMs with isoforms showing tissue specificity.
Integrating Activities of Laminins that Drive Basement Membrane Assembly and Function.
Yurchenco, United States. In Curr Top Membr, 2014
Studies on extracellular matrix proteins, cells, and genetically modified animals have converged to reveal mechanisms of basement membrane self-assembly as mediated by γ1 subunit-containing laminins, the focus of this chapter.
SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors.
Morrison et al., Dallas, United States. In Cell Stem Cell, 2013
Here we show that four SLAM family markers, CD150, CD48, CD229, and CD244, can distinguish HSCs and MPPs from restricted progenitors and subdivide them into a hierarchy of functionally distinct subpopulations with stepwise changes in cell-cycle status, self-renewal, and reconstituting potential.
RNA-binding protein IGF2BP2/IMP2 is required for laminin-β2 mRNA translation and is modulated by glucose concentration.
Abrass et al., Seattle, United States. In Am J Physiol Renal Physiol, 2012
Together, these studies provide evidence for regulation of Lamb2 translation by IMP2, an RNA binding protein that targets Lamb2 mRNA to the actin cytoskeleton.
HIV-1 infection ex vivo accelerates measles virus infection by upregulating signaling lymphocytic activation molecule (SLAM) in CD4+ T cells.
Tsunetsugu-Yokota et al., Tokyo, Japan. In J Virol, 2012
HIV-1 infection induces a high level of SLAM expression on CD4(+) T cells, which may enhance their susceptibility to measles virus and exacerbate measles in coinfected individuals.
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Veillette et al., Montréal, Canada. In Immunity, 2012
It coupled SLAM family receptors to the kinase Fyn, which triggered the exchange factor Vav-1 and augmented NK cell activation.
SAP signaling: a dual mechanism of action.
Shaw et al., Saint Louis, United States. In Immunity, 2012
(2012) show that the adaptor protein SAP regulates both positive and negative signals through SLAM receptors to stabilize intercellular contacts.
Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.
Terhorst et al., Boston, United States. In J Biol Chem, 2012
conclude that Slamf1 recruits a subset of Vps34-associated proteins, which is involved in membrane fusion and NOX2 regulation
Temporal progression of kainic acid induced changes in vascular laminin expression in rat brain with neuronal and glial correlates.
Schmued et al., United States. In Curr Neurovasc Res, 2012
In the hippocampus, thalamus, and piriform cortex both vascular lminin and astrocytic GFAP expression are up regulated following kainic acid injection.
Polymorphisms in DLGH1 and LAMC1 in Mayer-Rokitansky-Kuster-Hauser syndrome.
Darai et al., Paris, France. In Reprod Biomed Online, 2012
Mutations in the coding sequence of LAMC1 and DLGH1 may not be associated with Mayer-Rokitansky-Kuster-Hauser Syndrome.
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