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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

S-phase kinase-associated protein 1

Skp1, ANK, SphI, ANKH
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Cullin, SCF, CAN, ACID
Papers using Skp1 antibodies
Java Treeview—Extensible visualization of microarray data
Singh Malik Harmit, In PLoS Genetics, 2003
... Two to three micrograms of DNA were digested with AflII, EcoRI, or SphI (New England Biolabs, ...
Developments in the CCP4 molecular-graphics project
Wilkinson Anthony J et al., In Protein Science : A Publication of the Protein Society, 2003
... The PCR products were digested with SphI and BamHI and ligated into the similarly digested pQE-70 (QIAGEN) expression vector such that ...
A role for the actin cytoskeleton of Saccharomyces cerevisiae in bipolar bud-site selection
Lee Kyung S. et al., In The Journal of Cell Biology, 1996
... (pSK1059) was created by inserting the SstI-SphI fragment of CDC3 tagged NH2 terminally with YFP (a yellow-green variant of GFP; CLONTECH Laboratories, Inc.) into a pUC19- ...
Papers on Skp1
The role of genetic factors in the etiology of temporomandibular disorders: a review.
Di Giosia et al., Cagliari, Italy. In Cranio, Feb 2016
Such genes were mainly related to serotonin activity and metabolism, Tcellreceptor pathway, catecholamine activity and metabolism, estrogen activity, folate metabolism, glutathione activity, ANKH gene, major histocompatibility complex, extracellular matrix metabolism, genes studied in the orofacial pain prospective evaluation risk and assessment (OPPERA) study, and related to cytokines activity and metabolism.
KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.
Xiong et al., Shanghai, China. In Oncogene, Feb 2016
Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein.
Identification and characterization of an apoptosis-stimulating protein of p53 (ASPP) gene from Branchiostoma belcheri: Insights into evolution of ASPP gene family.
Ma et al., Qingdao, China. In Fish Shellfish Immunol, Jan 2016
The results showed that the amphioxus genome has an ASPP homolog gene with an ORF of 3285 bp, encoding 1094 amino acids which contains ANK repeats and SK3 domain.
Unilateral Anterior Crossbite Induces Aberrant Mineral Deposition in Degenerative Temporomandibular Cartilage in Rats.
Wang et al., Xi'an, China. In Osteoarthritis Cartilage, Jan 2016
The expression of mineralization inhibitors, NPP1, ANK, CD73, and MGP was decreased from 2-8 weeks post-UAC, so were the chondrogenic markers, Col-2, Col-X and aggrecan.
An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues.
Lorenzo et al., Durham, United States. In Curr Top Membr, Dec 2015
Ankyrins coordinate functionally related membrane transporters and cell adhesion proteins (15 protein families identified so far) within plasma membrane compartments through independently evolved interactions of intrinsically disordered sequences with a highly conserved peptide-binding groove formed by the ANK repeat solenoid.
Identification of sheep red blood cell (SRBC) surface immune-responsive peptides detected by antisera from SRBC-immunized rats.
Takeyoshi et al., Japan. In J Toxicol Sci, Dec 2015
Then the most intense immuno-reactive band on SDS-PAGE was subjected to nanoLC-ESI-MS/MS analysis, and 17 proteins were identified including membrane proteins of erythrocytes such as band 3 anion transport protein isoform 1 (Anion exchange protein 1; AE-1, CD233), Ammonium transporter Rh type A (Rh type A glycoprotein, CD241) and Ankyrin-1 (ANK-1), Spectrin beta chain.
Calcium pyrophosphate deposition disease: a review of epidemiologic findings.
Abhishek, Nottingham, United Kingdom. In Curr Opin Rheumatol, Dec 2015
It will summarize findings from a large dataset which reported that chondrocalcinosis results from a systemic predisposition, and that the association between chondrocalcinosis and polymorphisms in ANKH gene is independent of age and osteoarthritis.
The role of ANKH in pathologic mineralization of cartilage.
Williams, Camden, United States. In Curr Opin Rheumatol, Dec 2015
PURPOSE OF REVIEW: ANKH is the human homolog of a gene whose dysfunction in a mutant mouse strain results in progressive ankylosis of the spine as well as soft tissue mineralization.
The SCF-type E3 Ubiquitin Ligases as Cancer Targets.
Kitagawa et al., Hamamatsu, Japan. In Curr Cancer Drug Targets, Dec 2015
F-box proteins form SCF (SKP1-Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively target their substrates for degradation via the ubiquitin-proteasome pathway.
MicroRNA regulation of F-box proteins and its role in cancer.
Pfeffer et al., Memphis, United States. In Semin Cancer Biol, Nov 2015
F-box proteins function as the substrate-recognition components of the SKP1-CUL1-F-box (SCF)-ubiquitin ligase complex for the degradation of their protein targets by the ubiquitin-proteasome system.
Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
Bassermann et al., München, Germany. In Nat Med, 2014
FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex.
SCF ubiquitin ligase-targeted therapies.
Pagano et al., New York City, United States. In Nat Rev Drug Discov, 2014
F-box proteins are the substrate-targeting subunits of SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complexes.
Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.
Elefteriou et al., Nashville, United States. In Nat Med, 2014
We report here that ablation of Nf1 in bone-forming cells leads to supraphysiologic accumulation of pyrophosphate (PPi), a strong inhibitor of hydroxyapatite formation, and that a chronic extracellular signal-regulated kinase (ERK)-dependent increase in expression of genes promoting PPi synthesis and extracellular transport, namely Enpp1 and Ank, causes this phenotype.
Roles of F-box proteins in cancer.
Wei et al., Boston, United States. In Nat Rev Cancer, 2014
F-box proteins, which are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through ubiquitylation and subsequent degradation of target proteins.
Mechanisms and function of substrate recruitment by F-box proteins.
Pagano et al., New York City, United States. In Nat Rev Mol Cell Biol, 2013
S phase kinase-associated protein 1 (SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes use a family of F-box proteins as substrate adaptors to mediate the degradation of a large number of regulatory proteins involved in diverse processes.
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
Deshaies et al., Pasadena, United States. In J Biol Chem, 2012
Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism.
Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover.
Chen et al., San Diego, United States. In Mol Biol Cell, 2012
The interaction of KCTD6 with ankyrin-1 may have implications beyond muscle for hereditary spherocytosis, as KCTD6 is also present in erythrocytes, and erythrocyte ankyrin isoforms contain its mapped minimal binding site.
Intermittent Cyclic Mechanical Tension-Induced Calcification and downregulation of ankh gene expression of end plate chondrocytes.
Zhang et al., Wuhu, China. In Spine (phila Pa 1976), 2012
Results show that Cyclic Mechanical Tension (ICMT) induced the calcification and downregulation of ankh gene expression of end plate chondrocytes.
Novel ANKH amino terminus mutation (Pro5Ser) associated with early-onset calcium pyrophosphate disease with associated phosphaturia.
Terkeltaub et al., New York City, United States. In J Clin Rheumatol, 2012
We report a novel mutation, not previously described, in ANKH exon 1, wherein serine replaces proline, in a case of early-onset severe calcium pyrophosphate disease associated with metabolic abnormalities, with similar findings in the proband's father
GogB is an anti-inflammatory effector that limits tissue damage during Salmonella infection through interaction with human FBXO22 and Skp1.
Coombes et al., Hamilton, Canada. In Plos Pathog, 2011
we determined that the phage-encoded GogB effector protein in Salmonella targets the host SCF E3 type ubiquitin ligase through an interaction with Skp1 and the human F-box only 22 (FBXO22) protein
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