Two Faces of SIVA.
New York City, United States. In Cancer Discov, Jun 2015
In non-small cell lung cancer cells that contain a mutated KRAS gene, SIVA, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mTOR signaling.
Tubular p53 regulates multiple genes to mediate AKI.
Changsha, China. In J Am Soc Nephrol, 2014
Mechanistically, AKI associated with the upregulation of several known p53 target genes, including Bax, p53-upregulated modulator of apoptosis-α, p21, and Siva, and this association was attenuated in PT-p53-KO mice.