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SIVA1, apoptosis-inducing factor

Siva, Siva-1, CD27BP, Siva-2
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, CD27, PrP, CAN, V1a
Papers on Siva
Overexpression and Characterization of The C-Terminal Domain of Human Siva1, A Proapoptotic Factor and Cytoskeleton Binding Protein.
Bénichou et al., Campinas, Brazil. In Protein Pept Lett, Dec 2015
The C-terminus Siva1 domain (residues 84-175) was fused to glutathione Stransferase (GST) and expressed in an E coli system and the recombinant GST-Siva C-terminus was purified by GSTTagged Protein affinity and gel filtration chromatography.
Anticancer activity of recombinant Siva1 protein in human nasopharyngeal carcinoma cell line CNE-2.
Bai et al., In Cancer Biomark, Dec 2015
AIMS: To clone and express Siva1 protein, and to investigate the role of Siva1 protein in proliferation, apoptosis, invasion, and migration of human nasopharyngeal carcinoma cell line CNE-2 in vitro and in vivo.
Two Faces of SIVA.
Manfredi et al., New York City, United States. In Cancer Discov, Jun 2015
In non-small cell lung cancer cells that contain a mutated KRAS gene, SIVA, a p53 target gene that is critical for apoptosis, is overexpressed in a p53-independent manner and promotes tumorigenesis through the stimulation of mTOR signaling.
The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.
Attardi et al., Lyon, France. In Cancer Discov, Jun 2015
SIVA is a p53 target gene essential for p53-dependent apoptosis, although it can also promote proliferation through inhibition of p53 in some settings.
Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.
Bayat et al., Philadelphia, United States. In J Invest Dermatol, Apr 2015
SIVA1 promotes human double minute 2 homolog (HDM2)-mediated p53 regulation.
ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells.
Traina et al., Campinas, Brazil. In Biochim Biophys Acta, Mar 2015
In order to identify interaction partners of the ANKHD1 protein and its role in leukemia cells, we performed a yeast two-hybrid system screen and identified SIVA, a cellular protein known to be involved in proapoptotic signaling pathways.
Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury.
Padanilam et al., Cheju, South Korea. In J Am Soc Nephrol, 2014
Apoptosis and expression of proapoptotic p53 targets, including Bid and Siva, were also significantly reduced, and cell cycle arrest at the G2/M phase was attenuated in p53 KO ischemic kidneys.
Tubular p53 regulates multiple genes to mediate AKI.
Dong et al., Changsha, China. In J Am Soc Nephrol, 2014
Mechanistically, AKI associated with the upregulation of several known p53 target genes, including Bax, p53-upregulated modulator of apoptosis-α, p21, and Siva, and this association was attenuated in PT-p53-KO mice.
SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.
Huang et al., Hangzhou, China. In J Cell Biol, 2014
In this study, we used an affinity purification approach to isolate the PCNA-containing complex and have identified SIVA1 as a critical regulator of PCNA monoubiquitination.
The N-terminal 33 amino acid domain of Siva-1 is sufficient for nuclear localization.
Huang et al., Guangzhou, China. In Braz J Med Biol Res, 2014
Siva-1 induces apoptosis in multiple pathological processes and plays an important role in the suppression of tumor metastasis, protein degradation, and other functions.
Egr-1 upregulates Siva-1 expression and induces cardiac fibroblast apoptosis.
Aharinejad et al., Vienna, Austria. In Int J Mol Sci, 2013
Apoptotic induction was associated with a caspase activation associated loss of mitochondrial membrane potential and transient downstream transcriptional up-regulation of the pro-apoptotic gene product Siva-1.
Preliminary research on the expression, purification and function of the apoptotic fusion protein, Sival.
Yu et al., Suzhou, China. In Asian Pac J Cancer Prev, 2013
The objective of the present study was to investigate cloning, expression, and functions of the recombinant protein, Siva1.
Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.
Tigyi et al., Edmonton, Canada. In Biochim Biophys Acta, 2013
This results especially from the stimulation of LPA(2) receptors, which depletes the cell of Siva-1, a pro-apoptotic signaling protein and stimulates prosurvival kinase pathways through a mechanism mediated via TRIP-6.
Multifaceted functions of Siva-1: more than an Indian God of Destruction.
Wu et al., Hefei, China. In Protein Cell, 2012
Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines.
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules.
Wu et al., Hefei, China. In Proc Natl Acad Sci U S A, 2011
Data show that low levels of Siva1 and Ser16-phosphorylated stathmin correlate with high metastatic states of breast cancer cells.
p53 target Siva regulates apoptosis in ischemic kidneys.
Padanilam et al., Omaha, United States. In Am J Physiol Renal Physiol, 2011
Data indicate that p53 target Siva is pivotal in regulating apoptosis in the pathology of renal ischemia reperfusion injury.
Requirement for Siva-1 for replication of influenza A virus through apoptosis induction.
Miyazaki et al., Sapporo, Japan. In J Gen Virol, 2011
These findings suggest that the caspase-dependent pathway for induction of apoptosis is involved in Siva-1-mediated influenza A virus replication.
Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells.
Su et al., Chapel Hill, United States. In Bmc Immunol, 2010
negative regulator of IL-2 gene expression in Treg cells
The role of the pro-apoptotic protein Siva in the pathogenesis of Familial Mediterranean fever: A structural and functional analysis.
Boumpas et al., Irákleion, Greece. In Biochem Biophys Res Commun, 2010
These results suggest that Siva-mediated unprovoked apoptosis is not likely to be involved in the pathogenesis of Familial Mediterranean fever.
GITR: a multifaceted regulator of immunity belonging to the tumor necrosis factor receptor superfamily.
Riccardi et al., Perugia, Italy. In Eur J Immunol, 2005
The cytoplasmic region of GITR has a striking homology with other TNFRSF members (4-1BB, CD27, OX40) and binds TRAF molecules and Siva.
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