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Signal-regulatory protein gamma

SIRPgamma, SIRPbeta2, SIRP-B2, SIRPG
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: B it, CD47, HAD, erbB-3, V1a
Papers on SIRPgamma
Unbalanced translocations arise from diverse mutational mechanisms including chromothripsis.
Rudd et al., Atlanta, United States. In Genome Res, Jul 2015
Three simple translocations fuse genes that are predicted to produce in-frame transcripts of SIRPG-WWOX, SMOC2-PROX1, and PIEZO2-MTA1, which may lead to gain of function.
Association of 32 type 1 diabetes risk loci in Pakistani patients.
Kamboh et al., Islamabad, Pakistan. In Diabetes Res Clin Pract, Apr 2015
RESULTS: Our results showed significant association of 10 single nucleotide polymorphisms (SNPs) with T1D at p<0.01, including HLA-DQA1/rs9272346, ERBB3/rs2292239, SIRPG/rs2281808, IL2-KIAA1109/rs4505848, GLIS3/rs7020673, CD226/rs763361, PTPN2/rs478582, IKZF1/rs10272724, BACH2/rs11755527, C6orf173/rs9388489, whereas 5 more SNPs showed their association at 0.01<p<0.05 in Pakistani population.
Pathogenic variants screening in five non-obstructive azoospermia-associated genes.
Wang et al., Nanjing, China. In Mol Hum Reprod, 2014
1902301 in SIRPA), four common mutations (rs1048055 and rs2281807 in SIRPG, rs11046992 and rs146039840 in SOX5) were identified by using next generation sequencing (NGS).
Evaluation of five candidate genes from GWAS for association with oligozoospermia in a Han Chinese population.
Wang et al., Nanjing, China. In Plos One, 2012
RESULTS AND LIMITATIONS: Totally, we observed seven oligozoospermia associated variants (rs3791185 and rs2232015 in PRMT6, rs146039840 and rs11046992 in Sox5, rs1129332 in PEX10, rs3197744 in SIRPA, rs1048055 in SIRPG) in the first stage.
Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population.
She et al., Augusta, United States. In Genes Immun, 2011
Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.
Changes in the gene expression of peripheral blood mononuclear cells during the menstrual cycle of females is associated with a gender bias in the incidence of systemic lupus erythematosus.
Ogawa et al., Chiba, Japan. In Clin Exp Rheumatol, 2009
tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus.
A pipeline for the production of antibody fragments for structural studies using transient expression in HEK 293T cells.
Owens et al., Oxford, United Kingdom. In Protein Expr Purif, 2008
The pipeline is exemplified by the production of three Fabs derived from the monoclonal antibodies OX108 (anti-CD200 receptor), OX117 and OX119 (anti-SIRPgamma).
Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro.
Luscinskas et al., Boston, United States. In Blood, 2008
CD47 is enriched at endothelial junctions, and its interaction with SIRPgamma is required for human T-cell transendothelial migration
Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47.
Barclay et al., Oxford, United Kingdom. In Mol Cell, 2008
We have also determined structures of the N-terminal domains of SIRPbeta, SIRPbeta(2), and SIRPgamma; proteins that are closely related to SIRPalpha but bind CD47 with negligible or reduced affinity.
Novel structural determinants on SIRP alpha that mediate binding to CD47.
Parkos et al., Atlanta, United States. In J Immunol, 2008
Membrane distal (D1) domains of SIRPalpha and SIRPgamma, but not SIRPbeta, mediate binding to a cellular ligand termed CD47.
Signal regulatory proteins in the immune system.
van den Berg et al., Amsterdam, Netherlands. In J Immunol, 2006
Our analysis reveals SIRPs as a diverse multigene family of immune receptors, which includes inhibitory SIRPalpha, activating SIRPbeta, nonsignaling SIRPgamma, and soluble SIRPdelta members.
Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation.
Colonna et al., Saint Louis, United States. In Blood, 2005
A recently identified third member of the SIRP family, SIRPbeta2, is as yet uncharacterized in terms of expression, specificity, and function.
Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family.
Barclay et al., Oxford, United Kingdom. In J Immunol, 2004
a novel member of the signal regulatory protein (SIRP) family- with unique characteristics from both alpha and beta genes- termed SIRPgamma
Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family.
Hamaguchi et al., Nagoya, Japan. In J Hum Genet, 1999
A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library.
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