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Single-stranded DNA binding protein 1

single-stranded DNA binding protein
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010] (from NCBI)
Top mentioned proteins: SSB, CAN, POLYMERASE, ACID, RPA
Papers on single-stranded DNA binding protein
The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA-protein complexes.
Evans et al., Edmonton, Canada. In Virology, Feb 2016
UNASSIGNED: The vaccinia virus I3L gene encodes a single-stranded DNA binding protein (SSB) that is essential for virus DNA replication and is conserved in all Chordopoxviruses.
Mapping the interactions of the single-stranded DNA binding protein of bacteriophage T4 (gp32) with DNA lattices at single nucleotide resolution: polynucleotide binding and cooperativity.
von Hippel et al., Eugene, United States. In Nucleic Acids Res, Nov 2015
We here use our site-specific base analog mapping approach to study the interactions and binding equilibria of cooperatively-bound clusters of the single-stranded DNA binding protein (gp32) of the T4 DNA replication complex with longer ssDNA (and dsDNA) lattices.
Mapping the interactions of the single-stranded DNA binding protein of bacteriophage T4 (gp32) with DNA lattices at single nucleotide resolution: gp32 monomer binding.
von Hippel et al., Eugene, United States. In Nucleic Acids Res, Nov 2015
Combining biophysical measurements on T4 bacteriophage replication complexes with detailed structural information can illuminate the molecular mechanisms of these 'macromolecular machines'.
The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases.
Connolly et al., Newcastle upon Tyne, United Kingdom. In J Mol Biol, Oct 2015
RPA, the eukaryotic single-stranded DNA binding protein, also inhibits telomere resection.
Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways.
Chemla et al., Urbana, United States. In Elife, 2014
Escherichia coli single-stranded (ss)DNA binding (SSB) protein mediates genome maintenance processes by regulating access to ssDNA.
Defects of mitochondrial DNA replication.
Copeland, United States. In J Child Neurol, 2014
Mitochondrial DNA is replicated by DNA polymerase γ in concert with accessory proteins such as the mitochondrial DNA helicase, single-stranded DNA binding protein, topoisomerase, and initiating factors.
The interface of transcription and DNA replication in the mitochondria.
Copeland et al., United States. In Biochim Biophys Acta, 2012
This review focuses on the extension of RNA primers for DNA replication by the replication machinery and summarizes the current models of DNA replication in mitochondria as well as the proteins involved in mitochondrial DNA replication, namely, the DNA polymerase γ and its accessory subunit, the mitochondrial DNA helicase, the single-stranded DNA binding protein, topoisomerase I and IIIα and RNaseH1.
mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored.
Slupphaug et al., Trondheim, Norway. In Dna Repair (amst), 2012
Local enrichment of UNG1 at DNA-bound mtSSB may furthermore facilitate rapid access to- and processing of the damage once the dsDNA conformation is restored.
DNA polymerases: mechanistic insight from biochemical and biophysical studies.
Delagoutte, Paris, France. In Front Biosci, 2011
Auxiliary replication factors, such as the processivity factor or the single-stranded DNA binding protein, can also modulate the intrinsic properties of DNA polymerases and therefore fine-tune the.
Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.
Kaguni et al., East Lansing, United States. In J Biol Chem, 2011
mtSSB uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells
hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas.
Kang et al., Guangzhou, China. In Oncogene, 2011
hSSB1 may positively modulate p21 to regulate cell cycle progression and DNA damage response, implicating hSSB1 as a novel, promising therapeutic target for cancers such as hepatocellular carcinoma
Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation.
Yasukawa et al., London, United Kingdom. In Biochim Biophys Acta, 2010
Results describe the role of mitochondrial single-stranded DNA binding protein in the maintenance of mitochondrial DNA in cultured human cells.
Mechanistic and biological aspects of helicase action on damaged DNA.
Brosh et al., Baltimore, United States. In Cell Cycle, 2010
As a component of the replication stress response, the single-stranded DNA binding protein Replication Protein A (RPA) may serve to enable eukaryotic DNA helicases to overcome certain base lesions.
CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein.
Yu et al., London, United Kingdom. In Mol Cell Proteomics, 2010
Data show that mtSSB bound both CKS1 and CKS2 and underwent CDK-dependent phosphorylation.
Structural analysis of bacteriophage T4 DNA replication: a review in the Virology Journal series on bacteriophage T4 and its relatives.
Williams et al., Toledo, United States. In Virol J, 2009
The replicase includes the gp43 DNA polymerase, the gp45 processivity clamp, the gp44/62 clamp loader complex, and the gp32 single-stranded DNA binding protein.
Real-time observation of RecA filament dynamics with single monomer resolution.
Ha et al., Urbana, United States. In Cell, 2006
Although ordinarily single-stranded DNA binding protein (SSB) prevents filament nucleation, single RecA monomers can easily be added to an existing filament and displace SSB from DNA at the rate of filament extension.
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.
de Lange et al., New York City, United States. In Cell, 2006
Human telomeres are protected by shelterin, a complex that includes the POT1 single-stranded DNA binding protein.
Are mouse telomeres going to pot?
Baumann, Kansas City, United States. In Cell, 2006
Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length.
The DNA polymerase III holoenzyme: an asymmetric dimeric replicative complex with leading and lagging strand polymerases.
McHenry et al., Denver, United States. In Cell, 2001
We demonstrate that the nonhydrolyzable ATP analog, ATP gamma S, supports the formation of an isolable leading strand complex that loads and replicates the lagging strand only in the presence of ATP, beta, and the single-stranded DNA binding protein.
Single-Stranded DNA Binding Protein Encoded by the virE Locus of Agrobacterium tumefaciens.
Zambryski et al., In Science, 1988
Here, a novel 69-kilodalton vir-specific single-stranded DNA binding protein is identified in Agrobacterium harboring a nopaline-type Ti plasmid.
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