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Single-minded homolog 1

Sim1, Single-minded, SIMI, Single-minded 1
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Sim, CAN, HIF-1alpha, HAD, Midline
Papers on Sim1
S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.
Wang et al., Taipei, Taiwan. In Nucleic Acids Res, Feb 2016
Mre11 has two evolutionarily-conserved SUMO-interacting motifs, Mre11(SIM1) and Mre11(SIM2), which reside on the outermost surface of Mre11.
Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating IGF-1/PI3K/Akt/GSK-3β Signaling.
Yan et al., Nanjing, China. In Inflammation, Dec 2015
Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms.
Midline enhancer activity of the short gastrulation shadow enhancer is characterized by three unusual features for cis-regulatory DNA.
Hong et al., South Korea. In Bmb Rep, Oct 2015
Second, the midline enhancer activity relies on five Single-minded (Sim)-binding sites, two of which have not been found in any Sim target enhancers.
Hypoactivity following perturbed estrogen signaling in the medial amygdala.
Krashes et al., In J Clin Invest, Aug 2015
In this issue of the JCI, Xu and colleagues provide extensive evidence that ERα is abundant on neurons expressing single-minded-1 (SIM1) in the medial amygdala (MeA) and that loss of ERα in these cells enhances weight gain in both male and female mice, as the result of reduced physical activity.
Estrogen receptor-α in medial amygdala neurons regulates body weight.
Xu et al., In J Clin Invest, Aug 2015
Here we showed that single-minded-1 (SIM1) neurons in the medial amygdala (MeA) express abundant levels of ERα.
HSA21 Single-Minded 2 (Sim2) Binding Sites Co-Localize with Super-Enhancers and Pioneer Transcription Factors in Pluripotent Mouse ES Cells.
Antonarakis et al., Genève, Switzerland. In Plos One, 2014
The HSA21 encoded Single-minded 2 (SIM2) transcription factor has key neurological functions and is a good candidate to be involved in the cognitive impairment of Down syndrome.
Shared genetic aetiology of puberty timing between sexes and with health-related outcomes.
Perry et al., Cambridge, United States. In Nat Commun, 2014
However, some loci show sex-divergent effects, including directionally opposite effects between sexes at the SIM1/MCHR2 locus (Pheterogeneity=1.6 × 10(-12)).
Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation.
Tong et al., Houston, United States. In Cell Metab, 2014
Single-minded 1 (Sim1)-expressing brain regions, which include the paraventricular nucleus of hypothalamus (PVH), represent key brain sites that mediate melanocortin action.
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
Ashrafi et al., San Francisco, United States. In Cell Metab, 2012
Here, we show that neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons expressing the C. elegans counterpart of human SIM1, a transcription factor associated with obesity.
[Current progress in functions of axon guidance molecule Slit and underlying molecular mechanism].
Liu et al., China. In Sheng Li Xue Bao, 2012
Several transcription factors, including Single-minded, Irx and Midline, were shown to regulate slit expression.
Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2.
Powers et al., Davis, United States. In Proc Natl Acad Sci U S A, 2012
TORC2 has been shown previously to negatively regulate calcineurin in part by phosphorylating two related proteins, Slm1 and Slm2, which associate with the PM via plextrin homology domains
Replication and extension of association between common genetic variants in SIM1 and human adiposity.
Hsueh et al., San Francisco, United States. In Obesity (silver Spring), 2011
TagSNP analysis of SIM1 revealed two SNPs in the 3' region (rs9390322 and rs7746743) and another in intron 5 (rs3734353) to be significantly associated with various adiposity measures in ethnicity- and sex-specific manners...
Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure.
Kublaoui et al., Philadelphia, United States. In Plos One, 2011
Sim1 neurons in adult mice regulate both food intake and energy expenditure
Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons.
Roussa et al., Göttingen, Germany. In Plos One, 2010
Sim1 is a regulator of dorsal raphe nucleus specification acting upstream of Pet1 and Tph2.
Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression.
Kublaoui et al., Dallas, United States. In J Neurosci, 2010
Hyperphagic obesity in single-minded homolog 1 (Sim1)-deficient mice may be attributable to transgenic changes in the leptin-melanocortin-oxytocin pathway.
A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
Beckmann et al., London, United Kingdom. In Nature, 2010
Subsequent analysis of the loci so identified may well reveal additional rare variants that further contribute to the missing heritability, as recently reported for SIM1 (ref.
The role of the leptin-melanocortin signalling pathway in the control of food intake.
Van Hul et al., Antwerp, Belgium. In Crit Rev Eukaryot Gene Expr, 2008
These include the melanocortin-3 receptor, BDNF, SIM1, and nesfatin-1.
[Mandatory postgraduate medical training in Japan--present state of Nihon University as a private medical school].
Kumasaka, Tokyo, Japan. In Rinsho Byori, 2003
Single-minded specialization tends to produce single track minds, which may lack balanced judgment in approaching the appropriateness of both investigation and management.
Neuropathologic research strategies in holoprosencephaly.
Flores-Sarnat et al., Seattle, United States. In J Child Neurol, 2001
Secondary down-regulation of the OTP gene or of downstream genes such as BRN2 or SIM1 may result in failure of terminal differentiation of magnocellular neurons of the supraoptic and paraventricular hypothalamic nuclei.
Remembrance of things PAS: regulation of development by bHLH-PAS proteins.
Fan et al., Chapel Hill, United States. In Curr Opin Genet Dev, 1999
Recent studies using mouse knockouts of bHLH-PAS genes have provided novel insight into the roles of hypoxia inducible factors in controlling oxygen-regulated development and homeostasis, and the role of Single-minded-1 in regulating development and transcription in the hypothalamus.
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