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Sigma non-opioid intracellular receptor 1

sigma receptor, sigma-1 receptor
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: V1a, HAD, CAN, ACID, OUT
Papers on sigma receptor
Biochemical Pharmacology of the Sigma-1 Receptor.
Ruoho et al., Madison, United States. In Mol Pharmacol, Jan 2016
The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein.
A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor.
O'Driscoll et al., Cork, Ireland. In Int J Pharm, Jan 2016
Anisamide is known to bind specifically to the sigma receptor which is overexpressed on the surface of prostate cancer cells.
Antinociceptive effects of a new sigma-1 receptor antagonist (N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy)acetamide) in two types of nociception.
López-Muñoz et al., Mexico. In Eur J Pharmacol, Jan 2016
The aim of this study was to evaluate the antinociceptive effect of a new sigma-1 receptor antagonist N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy)acetamida (NMIN) in two types of pain (arthritic and neuropathic) and to compare its efficacy and potency with reference drugs.
Detection of Isolated Mitochondria-Associated ER Membranes Using the Sigma-1 Receptor.
Su et al., Baltimore, United States. In Methods Mol Biol, Dec 2015
We describe in detail the preparation and purification of the MAM by using the sigma-1 receptor as the marker and demonstrate the uniqueness of this marker by using a variety of cells, peripheral and neuronal.
Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope.
Su et al., Taipei, Taiwan. In Proc Natl Acad Sci U S A, Dec 2015
The sigma-1 receptor (Sig-1R) chaperone at the endoplasmic reticulum (ER) plays important roles in cellular regulation.
Roles of sigma-1 receptors in Alzheimer's disease.
Liu et al., Shanghai, China. In Int J Clin Exp Med, 2014
This article may pave the way for further studies about sigma-1 receptor on Alzheimer's disease.
Investigational sigma-1 receptor antagonists for the treatment of pain.
Almansa et al., Barcelona, Spain. In Expert Opin Investig Drugs, 2014
INTRODUCTION: The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone that interacts with other proteins, including NMDA and opioid receptors, to modulate their activity.
Sigma-1 receptors and animal studies centered on pain and analgesia.
Davis, Cleveland, United States. In Expert Opin Drug Discov, 2014
Therefore, sigma-1 receptor antagonists are potential analgesics for neuropathic and adjuvants to opioid therapy.
Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation.
Liu et al., Xuzhou, China. In Mediators Inflamm, 2014
Previous studies have demonstrated that sigma-1 receptor plays important roles in the induction phase of rodent neuropathic pain; however, whether it is involved in bone cancer pain (BCP) and the underlying mechanisms remain elusive.
Sigma Receptor Binding Assays.
Ruoho et al., Madison, United States. In Curr Protoc Pharmacol, 2014
Procedures using [(3) H]-1,3-di(2-tolyl)guanidine ([(3) H]-DTG), a nonselective sigma receptor ligand, are described for conducting a saturation binding and competitive inhibition assays for the S2R site.
Review of Dextromethorphan 20 mg/Quinidine 10 mg (NUEDEXTA(®)) for Pseudobulbar Affect.
Pioro, Cleveland, United States. In Neurol Ther, 2014
DM is an uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist, a sigma-1 receptor agonist, and a serotonin and norepinephrine reuptake inhibitor.
Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.
Bonci et al., Baltimore, United States. In Cell, 2013
The sigma-1 receptor (Sig-1R), an endoplasmic reticulum (ER) chaperone protein, is an interorganelle signaling modulator that potentially plays a role in drug-seeking behaviors.
Expression of a truncated form of the endoplasmic reticulum chaperone protein, σ1 receptor, promotes mitochondrial energy depletion and apoptosis.
Fukunaga et al., Sendai, Japan. In J Biol Chem, 2012
Data indicate that sigma1-receptor short form sigma(1)SR isoform interferes with sigma(1)R function relevant to mitochondrial energy production under endoplasmic reticulum stress conditions, promoting cellular apoptosis.
Association between a variant of the sigma-1 receptor gene and Alzheimer's disease.
Janka et al., Szeged, Hungary. In Neurosci Lett, 2012
Our data demonstrates an association between the SIGMAR1 TT-P variant and the risk for developing Alzheimer's diseasE
Overexpression of sigma1 receptor and its positive associations with pathologic TNM classification in esophageal squamous cell carcinoma.
Xu et al., Shantou, China. In J Histochem Cytochem, 2012
sigma1R may serve as a potential predictive factor for pTNM classification and tumor development in esophageal squamous cell carcinoma.
The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.
Ruoho et al., Madison, United States. In Eur J Pharmacol, 2012
novel functions of the sigma-1 receptor
Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands.
Yang et al., Madison, United States. In Brain Res, 2012
Sigma1R likely interacts with different domains of Kv ion channel family proteins resulting in distinct modulation of different channels.
The hallucinogen N,N-dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator.
Ruoho et al., Madison, United States. In Science, 2009
The sigma-1 receptor is widely distributed in the central nervous system and periphery.
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
Su et al., Baltimore, United States. In Cell, 2007
Endoplasmic reticulum (ER) protein sigma-1 receptor (Sig-1R), is a Ca(2+)-sensitive and ligand-operated receptor chaperone at mitochondrion-associated ER membrane.
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.
Jaffe et al., Baltimore, United States. In Science, 1988
In this study, certain gonadal and adrenal steroids, particularly progesterone, were found to inhibit sigma receptor binding in homogenates of brain and spleen.
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