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Sialic acid binding Ig-like lectin 6

Siglec-6, obesity-binding protein 1, OB-BP1
Top mentioned proteins: ACID, CD33, CD45, leptin, Sialoadhesin
Papers on Siglec-6
Differential Proteomic Analysis of Syncytiotrophoblast Extracellular Vesicles from Early-Onset Severe Preeclampsia, using 8-Plex iTRAQ Labeling Coupled with 2D Nano LC-MS/MS.
Li et al., Chongqing, China. In Cell Physiol Biochem, 2014
Four differentially expressed proteins (siglec-6, calnexin, CD63 and S100-A8) related to inflammation, coagulation or immunoregulation were independently verified using western blot.
An updated view of leptin on implantation and pregnancy: a review.
McFarlane et al., Armidale, Australia. In Physiol Res, 2013
Leptin circulates in biological fluids both as free protein and in a form that is bound to the soluble isoform of its receptor or other binding proteins such as one of the immunoglobulin superfamily members Siglec-6 (OB-BP1).
Glycodelin-A protein interacts with Siglec-6 protein to suppress trophoblast invasiveness by down-regulating extracellular signal-regulated kinase (ERK)/c-Jun signaling pathway.
Yeung et al., Hong Kong, Hong Kong. In J Biol Chem, 2011
GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway.
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.
Fisher et al., San Francisco, United States. In Endocrinology, 2009
Preeclampsia involves changes in the gene expression of SIGLEC6 in placental cytotrophoblasts.
Human-specific expression of Siglec-6 in the placenta.
Varki et al., San Diego, United States. In Glycobiology, 2007
the negative signaling potential of Siglec-6 may have a role in human-specific placental expression, to slow the tempo of the human birth process
New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins.
Varki et al., San Diego, United States. In J Biol Chem, 2000
Fourth, siglecs-2 (CD22), -3, -5, and -6 (obesity-binding protein 1) showed significant binding to sialyl-Tn (Neu5Acalpha2-6-GalNAc), a tumor marker associated with poor prognosis.
Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs.
Varki et al., San Diego, United States. In J Biol Chem, 2000
Human siglec-3 (CD33) and siglec-6 (obesity-binding protein 1) also recognize both Neu5Ac and Neu5Gc, and siglec-5 may have some preference for Neu5Gc.
Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily.
Crocker et al., Dundee, United Kingdom. In J Biol Chem, 2000
closely linked to genes encoding CD33 (siglec-3), siglec-5, siglec-6, and siglec-7.
Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes.
Crocker et al., Dundee, United Kingdom. In J Biol Chem, 1999
Overall, siglec-7 exhibited a high degree of sequence similarity to genes encoding CD33 (siglec-3), siglec-5, OBBP1/siglec-6, and OBBP-like protein and mapped to the same region on chromosome 19q13.3.
OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily.
Kastelein et al., Palo Alto, United States. In J Biol Chem, 1999
Studies with sialylated ligands indicated that OB-BP1 selectively bound Neu5Acalpha2-6GalNAcalpha (sialyl-Tn) allowing its formal designation as Siglec-6.
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