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Seven in absentia homolog 1

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, p53, Siah2, V1a, CAN
Papers using Siah-1 antibodies
From Mallory to Mallory-Denk bodies: What, how and why?
Omary M. Bishr et al., In The Journal of Cell Biology, 2006
... NDPK-A (NME1), NDPK-B (NME2), PSMC6, GAPDH (6C5), CYP3A1, FAH, PDIA4 (ERp72), lamin B1, PRDX6, and Siah1 (Abcam); GSTM1, CBR3, CA3, and ...
Papers on Siah-1
Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.
Snyder et al., Baltimore, United States. In Mol Psychiatry, Feb 2016
Nitrosylated GAPDH complexes with the ubiquitin-E3-ligase Siah1 and Rheb, a small G protein that activates mTOR.
SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.
Algire et al., Heidelberg, Germany. In Cell Cycle, Jan 2016
Seven-in-absentia homolog (SIAH) proteins are evolutionary conserved RING type E3 ubiquitin ligases responsible for the degradation of key molecules regulating DNA damage response, hypoxic adaptation, apoptosis, angiogenesis, and cell proliferation.
The E3 ubiquitin ligase seven in absentia homolog 1 may be a potential new therapeutic target for Parkinson's disease.
Li et al., Xinpu, China. In Neural Regen Res, Aug 2015
In this study, we investigated the effect of an antibody against E3 ubiquitin ligase seven in absentia homolog 1 (SIAH-1) in PC12 cells.
The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers.
Krämer et al., Essen, Germany. In Cytokine Growth Factor Rev, Aug 2015
An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and SIAH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells.
Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease.
Chakrabarti et al., Calcutta, India. In Biochem Cell Biol, Aug 2015
Some of the ubiquitin ligases regulating these proteins include PARK2, BRCA1/BARD1, MGRN1, SMURF2, and SIAH1; these play a pivotal role in the correct positioning of the spindle apparatus.
[Regulatory mechanism of Siah1 in the pathogenesis of rat hypoxic pulmonary hypertension].
Zhu et al., In Zhonghua Yi Xue Za Zhi, Aug 2015
There was a positive correlation between the relative levels of Siahi mRNA and Siahl protein (r = 0. 823, P <0.
Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.
Sabapathy et al., Singapore, Singapore. In Nat Cell Biol, Apr 2015
We show here that TAp73 is stabilized by hypoxia, a condition highly prevalent in tumours, through HIF-1α-mediated repression of the ubiquitin ligase Siah1, which targets TAp73 for degradation.
Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine.
Snyder et al., Baltimore, United States. In Cns Neurol Disord Drug Targets, 2014
We describe a signaling system wherein lower behavioral stimulant doses of cocaine, as well as higher neurotoxic doses, activate a cascade wherein nitric oxide nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to generate a complex with the ubiquitin-E3-ligase Siah1 which translocates to the nucleus.
Silencing of SIAH1 in SH-SY5Y affects α-synuclein degradation pathway.
Li et al., Xinpu, China. In Int J Clin Exp Pathol, 2014
Seven in absentia homolog (SIAH) is a ubiquitin ligase that monoubiquitinates α-synuclein.
SIAH proteins: critical roles in leukemogenesis.
Knauer et al., Jena, Germany. In Leukemia, 2013
Here, we summarize functions of SIAH ubiquitin-ligases in leukemias, how they select leukemia-relevant substrates for proteasomal degradation, and how the expression and activity of SIAH1 and SIAH2 can be modulated in vivo.
Lessons from tumor reversion for cancer treatment.
Telerman et al., Cachan, France. In Curr Opin Oncol, 2013
Differential gene-expression profiling showed that at least 300 genes are implicated in this reversion process such as SIAH-1, PS1, TSAP6, and, most importantly, translationally controlled tumor protein (TPT1/TCTP).
The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription.
Zhou et al., Xiamen, China. In Mol Cell, 2012
Siah1 is the E3 ubiquitin ligase for ELL2 polyubiquitination and proteasomal degradation.
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
He et al., New York City, United States. In Nat Med, 2012
HIV infection increased the protein concentrations of HIPK2 by promoting oxidative stress, which inhibited the seven in absentia homolog 1 (SIAH1)-mediated proteasomal degradation of HIPK2.
Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Krämer et al., Jena, Germany. In Int J Biochem Cell Biol, 2012
In sharp contrast to SIAH1/SIAH2 and UBCH8, TRIAD1 binding to PML-RARalpha has no effect on its turnover.
Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.
Huo et al., Shanghai, China. In Mol Cell Biochem, 2011
Taken together, our data suggest EFF1D functions as a novel negative regulator of SIAH-1.
E3 ubiquitin ligase Siah-1 facilitates poly-ubiquitylation and proteasomal degradation of the hepatitis B viral X protein.
Yu et al., Shanghai, China. In Febs Lett, 2011
Siah-1 may play an important role in ubiquitin-dependent degradation of hepatitis B virus X protein and may be involved in suppressing the progression of hepatocellular carcinoma (HCC).
Herpes simplex virus immediate-early protein ICP0 is targeted by SIAH-1 for proteasomal degradation.
Hauber et al., Hamburg, Germany. In J Virol, 2011
infection of SIAH-1 knockdown cells with HSV, higher levels of ICP0 were produced, ICP0 was less ubiquitinated, and the half-life of this multifunctional viral regulatory protein was increased
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.
Harris et al., Bethesda, United States. In Nat Cell Biol, 2010
Here, we identify a signalling pathway involving p53, Siah1 (a p53-inducible E3 ubiquitin ligase) and TRF2 (telomere repeat binding factor 2; a component of the shelterin complex).
GAPDH mediates nitrosylation of nuclear proteins.
Snyder et al., Baltimore, United States. In Nat Cell Biol, 2010
Nitrosylated GAPDH (SNO-GAPDH) binds to Siah1, which possesses a nuclear localization signal, and is transported to the nucleus.
The molecular programme of tumour reversion: the steps beyond malignant transformation.
Amson et al., Cachan, France. In Nat Rev Cancer, 2009
Studying these extremely rare events of tumour reversion and deciphering these pathways, which involve SIAH1, presenilin 1, TSAP6 and translationally controlled tumour protein (TCTP), could lead to new avenues in cancer treatment.
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