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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Protein tyrosine phosphatase, non-receptor type 6

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NS1, Src, V1a, CAN, ACID
Papers using SHP1 antibodies
Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA
Evers Raymond et al., In Nucleic Acids Research, 2006
... -N-CoR (sc-8994), -HNF4α (sc-8987), -GRIP-1 (sc-8996), -PGC-1α (sc-13067), -SMRT (sc-1610), -FKHR (sc-11350), -RIP140 (sc-8997) and -SHP (sc-15283) antibodies were purchased from Santa Cruz Biotechnology Inc ...
In situ measurement of degranulation as a biosensor based on RBL-2H3 mast cells.
Zhang Xin, In PLoS ONE, 2003
... Rabbit antibody to Erk2, PLCγ2, Shp1, and HRP-conjugated antibodies to mouse and rabbit immunoglobulin were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
A population of PC12 cells that is initiating apoptosis can be rescued by nerve growth factor.
Faivre-Sarrailh Catherine, In PLoS ONE, 2000
... and anti-SHP-1 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
Levamisole induced apoptosis in cultured vascular endothelial cells
HOUEN GUNNAR et al., In Apmis, 1999
... Clodronate disodium salt, salubrinal, Protein tyrosine phosphatase 1B (PTP1B) inhibitor, Shp1/2 inhibitor (NSC87877), PTP inhibitor I, II, and IV were from Merck (Darmstadt, Germany) ...
Receptor tyrosine kinase c-ros knockout mice as a model for the study of epididymal regulation of sperm function
Böhmer Frank D. et al., In The Journal of Cell Biology, 1997
... Polyclonal anti-phosphotyrosine and monoclonal anti–SHP-1 antibodies were obtained from Transduction Laboratories, polyclonal anti–SHP-1 antibodies and the corresponding blocking peptide from Santa Cruz Biotechnology, Inc., and anti-vinculin monoclonal ...
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Papers on SHP1
Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.
Peng et al., Zhanjiang, China. In Int J Oncol, Feb 2016
Cell viability, survival, DNA double-strand breaks (DSB), apoptosis, cell cycle distribution, expression of SHP-1 and other related proteins were detected with MTT assay, colony formation assay, immunofluorescent assay, flow cytometry and western blot analysis, respectively.
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis.
Rafei et al., Montréal, Canada. In Aging Cell, Feb 2016
Enhanced production of naïve T cells improved the T-cell receptor (TCR) repertoire diversity and re-established a pool of T cells exhibiting higher levels of miR-181a and diminished amounts of the TCR-inhibiting phosphatases SHP-2 and DUSP5/6.
Small Heterodimer Partner and Innate Immune Regulation.
Jo et al., Taejŏn, South Korea. In Endocrinol Metab (seoul), Feb 2016
Small heterodimer partner (SHP) is an orphan family nuclear receptor that plays an essential role in the regulation of glucose and cholesterol metabolism.
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
Zhang et al., Dallas, United States. In Cell Cycle, Feb 2016
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatase non-receptor type 6 (PTPN6 or SHP-1), protein tyrosine phosphatase non-receptor type 11 (PTPN11 or SHP-2), or Src homology 2 domain-containing inositol phosphatase (SHIP), leading to negative regulation of immune cell activation.
Enhanced Tyrosine Phosphatase Activity Underlies Dysregulated B-cell Receptor Signaling and Promotes Survival of Human Lupus B-cells.
Dörner et al., Berlin, Germany. In Arthritis Rheumatol, Jan 2016
Confocal microscopy studies determined the recruitment of CD22 and the tyrosine phosphatase SHP-1 to the activated BCR complex.
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.
Guo et al., Shanghai, China. In Bioorg Med Chem Lett, Jan 2016
Their inhibitory effects on PTP1B and other PTPs (TCPTP, SHP1, SHP2 and LAR) were evaluated.
Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through.
Mechta-Grigoriou et al., Paris, France. In Nat Commun, Dec 2015
Here, we find that miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested.
Inhibitory leukocyte immunoglobulin-like receptors in cancer development.
Zhang et al., Shanghai, China. In Sci China Life Sci, Dec 2015
Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation.
Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.
Sebo et al., Praha, Czech Republic. In Pathog Dis, Nov 2015
Among other effects, this yields activation of the tyrosine phosphatase SHP-1, BimEL accumulation and phagocyte apoptosis induction.
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses.
Xiao et al., Shanghai, China. In Nat Immunol, Jun 2015
Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk.
The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.
Zhang et al., Dallas, United States. In Nat Cell Biol, May 2015
LAIR1 induces activation of SHP-1, which acts as a phosphatase-independent signalling adaptor to recruit CAMK1 for activation of downstream CREB in AML cells.
The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation.
Cao et al., Shanghai, China. In Science, 2014
lnc-DC bound directly to STAT3 in the cytoplasm, which promoted STAT3 phosphorylation on tyrosine-705 by preventing STAT3 binding to and dephosphorylation by SHP1.
Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin.
Vestweber et al., Münster, Germany. In Nat Immunol, 2014
Leukocytes triggered dephosphorylation of Tyr731 via the tyrosine phosphatase SHP-2, which allowed the adaptin AP-2 to bind and initiate endocytosis of VE-cadherin.
Themis sets the signal threshold for positive and negative selection in T-cell development.
Gascoigne et al., Los Angeles, United States. In Nature, 2014
Here we show that positive selection is enabled by the ability of the T-cell-specific protein Themis to specifically attenuate TCR signal strength via SHP1 recruitment and activation in response to low- but not high-affinity TCR engagement.
The protein tyrosine phosphatase SHP-1 regulates phagolysosome biogenesis.
Descoteaux et al., Québec, Canada. In J Immunol, 2012
SHP-1 is recruited early to phagosomes and that it is required for the acquisition of macrophage lysosomal features and acidification.
Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.
McSorley et al., Davis, United States. In J Immunol, 2012
SIRPalpha demonstrates an indispensable role for protective immunity in Salmonella infection.
Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivo.
Greenberg et al., Seattle, United States. In J Immunol, 2012
These studies suggest that abrogating SHP-1 in effector T cells may improve the efficacy of tumor elimination by T cell therapy without affecting the ability of the effector cells to persist and provide a long-term response.
SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.
Li et al., Wuhan, China. In J Neurochem, 2012
These results provide the first demonstration that SHPS-1 plays an important role in the oxidative stress and brain injury induced by acute cerebral ischemia
LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.
Brdicka et al., Praha, Czech Republic. In J Biol Chem, 2012
LST1 is expressed specifically in leukocytes of the myeloid lineage, where it localizes to the tetraspanin-enriched microdomains and it binds SHP-1 and SHP-2 phosphatases.
More papers using SHP1 antibodies
Negative Regulation of Mast Cell Signaling and Function by the Adaptor LAB/NTAL
Dráber Petr et al., In The Journal of Experimental Medicine, 1995
... PLCγ1, PLCγ2, ERK 1, phospho-ERK (specific for phosphorylated Tyr 204), Grb2, SH2-containing protein tyrosine phosphatase (SHP)-2, and horseradish peroxidase (HRP)–conjugated donkey anti–goat IgG, goat anti–mouse IgG, and goat anti–rabbit IgG were obtained from Santa Cruz Biotechnology, Inc ...
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