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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Short stature homeobox 2

Shox2, SHOT, OG12X, OG-12
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] (from NCBI)
Top mentioned proteins: CAN, Nkx2.5, ACID, BMP4, FATE
Papers on Shox2
The value of SHOX2 methylation test in peripheral blood samples used for the differential diagnosis of lung cancer and other lung disorders.
Majer et al., In Neoplasma, Feb 2016
Several epigenetic cancer markers have been reported to be detectable in body fluids such as bronchial aspirate, sputum, plasma and serum.Short stature homeobox gene 2 (SHOX2) encodes a homeo-domain transcription factor, which has been identified as a close homologue of the SHOX gene and both genes are involved in skeletogenesis and heart development.
Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes from Retinoblastoma Haploinsufficient Mice.
Ribot et al., Palma, Spain. In J Cell Physiol, Feb 2016
Primary white Rb(+/-) adipocytes displayed under basal conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b), but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, Shox2).
A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.
Jiang et al., Cincinnati, United States. In Plos Genet, Jan 2016
We found that Foxf2 mutant embryos exhibit altered patterns of expression of Shh, Ptch1, and Shox2 in the developing palatal shelves.
Role of SHOX2 in the development of intervertebral disc degeneration.
Leung et al., Guangzhou, China. In J Orthop Res, Jan 2016
In this study, we investigated the role of SHOX2 in the development of IVD degeneration.
Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole.
Chen et al., New Orleans, United States. In J Cardiovasc Dev Dis, Dec 2015
UNASSIGNED: The definitive sinoatrial node (SAN), the primary pacemaker of the mammalian heart, develops from part of pro-pacemaking embryonic venous pole that expresses both Hcn4 and the transcriptional factor Shox2.
Expression of developmental genes in brown fat cells grown in vitro is linked with lipid accumulation.
Grover et al., Karnāl, India. In In Vitro Cell Dev Biol Anim, Nov 2015
En1, Nr2f1, Gpc4, Sfrp2, Shox2, Tbx15 and Thbd are among the genes involved in development process of an organism in a number of tissues, in particular adipose tissue.
Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons(1,2,3).
Shevtsova et al., Philadelphia, United States. In Eneuro, Sep 2015
However, significant progress has been made in the molecular/genetic identification of several types of spinal interneurons, including V0 (V0D and V0V subtypes), V1, V2a, V2b, V3, and Shox2, among others.
Diagnosis of Lung Cancer by SHOX2 Gene Methylation Assay.
Li et al., Beijing, China. In Mol Diagn Ther, Jun 2015
The SHOX2 gene methylation assay has become a promising option for the above purposes.
Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.
Pinnick et al., Oxford, United Kingdom. In Nat Rev Endocrinol, Feb 2015
New data suggest that the profound functional differences between the upper-body and lower-body tissues are controlled by site-specific sets of developmental genes, such as HOXA6, HOXA5, HOXA3, IRX2 and TBX5 in subcutaneous abdominal adipose tissue and HOTAIR, SHOX2 and HOXC11 in gluteofemoral adipose tissue, which are under epigenetic control.
Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves.
Cobb et al., Calgary, Canada. In Bmc Neurosci, 2014
Given that our previous study identified a novel role for the short stature homeobox 2 (Shox2) gene in the hindbrain, and since SHOX2 has been shown to regulate transcription of islet 1 (Isl1), an important regulator of vMN development, we sought to determine whether Shox2 is required for the proper development of the facial motor nucleus.
Aberrant methylation patterns in cancer: a clinical view.
Hudler et al., Ljubljana, Slovenia. In Biochem Med (zagreb), 2014
Even more, promoter methylation patterns of some genes, such as MGMT, SHOX2, and SEPT9, have already been translated into commercial clinical assays aiding in patient assessment as adjunct diagnostic tools.
Diagnostic value of SHOX2 DNA methylation in lung cancer: a meta-analysis.
Duan et al., Shijiazhuang, China. In Onco Targets Ther, 2014
The diagnostic value of SHOX2 DNA methylation in patients with lung cancer remains controversial.
Mapping Mammalian Cell-type-specific Transcriptional Regulatory Networks Using KD-CAGE and ChIP-seq Data in the TC-YIK Cell Line.
Forrest et al., Yokohama, Japan. In Front Genet, 2014
In the core TRN (i.e., TF-TF only), NEUROD1 directly transcriptionally activates the pancreatic TFs HSF4, INSM1, MLXIPL, MYT1, NKX6-3, ONECUT2, PAX4, PROX1, RFX6, ST18, DACH1, and SHOX2, while LMX1A directly transcriptionally activates DACH1, SHOX2, PAX6, and PDX1.
Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.
Potter et al., Cincinnati, United States. In Bmc Dev Biol, 2014
In addition of the Hox mutants showed strongly altered expression of Pknox2, Zfp467, Gdf5, Bmpr1b, Dkk3, Igf1, Hand2, Shox2, Runx3, Bmp7 and Lef1, all of which have been previously shown to play important roles in bone formation.
DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients.
Soltermann et al., Bonn, Germany. In Diagn Mol Pathol, 2012
DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients.
DNA methylation biomarkers in cancer: progress towards clinical implementation.
Dobrovic et al., Melbourne, Australia. In Expert Rev Mol Diagn, 2012
Finally, we summarize the current state of clinical implementation for some of the most widely studied and well-validated DNA methylation biomarkers, including SEPT9, VIM, SHOX2, PITX2 and MGMT.
Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates.
Field et al., Berlin, Germany. In Int J Oncol, 2012
A CE marked in vitro diagnostic test kit to quantify SHOX2 DNA methylation in bronchial aspirates was developed and characterized.
Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch.
Ernfors et al., Stockholm, Sweden. In Eur J Neurosci, 2011
These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin.
SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma.
Dietrich et al., Mainz, Germany. In J Thorac Oncol, 2011
SHOX2 DNA methylation is associated with lung cancer.
Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.
Wang et al., Durham, United States. In J Neurosci, 2011
our findings identify Shox2 as an essential but not sufficient component of the transcription programs required in neural progenitor cells for the proper specification of subsets of TrkB-expressing touch/mechanosensory neurons.
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