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SH2B adaptor protein 1

SH2-B, SH2B1
This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Insulin, fibrillin-1, FTO, Src, MC4R
Papers using SH2-B antibodies
Papers on SH2-B
SH2B1 orchestrates signaling events to filopodium formation during neurite outgrowth.
Chen et al., Huazhou, China. In Commun Integr Biol, Jul 2015
SH2B1 is known to promote neurite outgrowth of PC12 cells, hippocampal and cortical neurons.
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Schiöth et al., Uppsala, Sweden. In Genome Med, 2014
Out of 107 CpG sites, 38 are located in gene promoters, including genes strongly implicated in obesity (MIR148A, BDNF, PTPMT1, NR1H3, MGAT1, SCGB3A1, HOXC12, PMAIP1, PSIP1, RPS10-NUDT3, RPS10, SKOR1, MAP2K5, SIX5, AGRN, IMMP1L, ELP4, ITIH4, SEMA3G, POMC, ADCY3, SSPN, LGR4, TUFM, MIR4721, SULT1A1, SULT1A2, APOBR, CLN3, SPNS1, SH2B1, ATXN2L, and IL27).
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.
Gilbert-Diamond et al., United States. In Biodata Min, 2014
In this study, we aimed to analyze pairwise interactions that are associated with Body Mass Index (BMI) between SNPs from twelve genes robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18).
Association of adenovirus 36 infection with obesity-related gene variants in adolescents.
Hainer et al., Praha, Czech Republic. In Physiol Res, 2014
Genotyping of ten gene variants (in/near TMEM18, SH2B1, KCTD15, PCSK1, BDNF, SEC16B, MC4R, FTO) and analysis of Adv36 antibodies was performed in 1,027 Czech adolescents aged 13.0-17.9
Obesity-Related Genetic Variants and their Associations with Physical Activity.
Pescatello et al., Providence, United States. In Sports Med Open, 2014
Due to the pleiotropic effects of related phenotypes, we tested six of these obesity-related genetic variants for their association with physical activity: fat mass and obesity-associated (FTO)(rs9939609)T>A, potassium channel tetramerization domain containing (KCTD15) (rs11084753)G>A, melanocortin receptor4 (MC4R)(rs17782313)T>C, neuronal growth regulator 1 (NEGR1)(rs2815752)A>G, SH2B adapter protein 1 (SH2B1)(rs7498665)A>G, and transmembrane protein18 (TMEM18)(rs6548238)C>T.
20 years of leptin: connecting leptin signaling to biological function.
Myers et al., Ann Arbor, United States. In J Endocrinol, 2014
LepRb activation and subsequent tyrosine phosphorylation recruits and activates multiple signaling pathways, including STAT transcription factors, SHP2 and ERK signaling, the IRS-protein/PI3Kinase pathway, and SH2B1.
SH2B1 regulation of energy balance, body weight, and glucose metabolism.
Rui, Ann Arbor, United States. In World J Diabetes, 2014
SH2B1 (also called SH2-B and PSM) and SH2B2 (also called APS) are able to form homo- or hetero-dimers via their N-terminal dimerization domains.
Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins.
Burnol et al., Paris, France. In Febs J, 2013
This review focuses on the regulation of insulin/IGF-1 signaling and action by two adaptor families with a similar domain organization: the growth factor receptor-bound proteins Grb7/10/14 and the SH2B proteins.
Functional analysis of seven genes linked to body mass index and adiposity by genome-wide association studies: a review.
Speakman, Beijing, China. In Hum Hered, 2012
The remaining 7 SNPs are adjacent to, or within, the genes NEGR1, TMEM18, ETV5, FLJ35779, LINGO2, SH2B1 and GIPR, most of which are less well studied than FTO, particularly in the context of obesity.
Genetic determinants of obesity and related vascular diseases.
Back et al., Marburg an der Lahn, Germany. In Vitam Horm, 2012
In addition to common variants, FTO and MC4R, new loci, such as TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, and NEGR1 have been detected.
The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.
Barber et al., Toronto, Canada. In J Biol Chem, 2012
SH2B1 is responsive to erythropoietin stimulation and becomes phosphorylated
The role of obesity-related genetic loci in insulin sensitivity.
Ingelsson et al., Stockholm, Sweden. In Diabet Med, 2012
Our study supports earlier reports of SH2B1 to be of importance in insulin sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2.
The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.
Trischitta et al., San Giovanni Rotondo, Italy. In Atherosclerosis, 2011
Variability at the SH2B1 obesity locus is associated with myocardial infarction in type 2 diabetic patients and with reduced insulin-stimulated nitric oxide synthase activity in human endothelial cells.
Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.
Carter-Su et al., Ann Arbor, United States. In J Cell Sci, 2011
serves as a focal adhesion protein that regulates focal adhesion size and number
Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population.
Van Hul et al., Antwerp, Belgium. In Obes Facts, 2010
With the current study we were able to replicate and confirm that the SH2B1 gene locus is significantly associated with complex obesity in a Caucasian population.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Loos et al., Cambridge, United States. In Nat Genet, 2010
Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor.
SH2B regulation of growth, metabolism, and longevity in both insects and mammals.
Rui et al., Shanghai, China. In Cell Metab, 2010
Genetic deletion of SH2B1 also resulted in growth retardation, obesity, and type 2 diabetes in mice; surprisingly, life span and oxidative resistance were reduced in SH2B1 null mice.
Large, rare chromosomal deletions associated with severe early-onset obesity.
Farooqi et al., Cambridge, United Kingdom. In Nature, 2010
deletions encompass several genes but include SH2B1, which is known to be involved in leptin and insulin signalling.
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
Stefansson et al., Reykjavík, Iceland. In Nat Genet, 2009
This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Genetic Investigation of ANthropometric Traits Consortium et al., In Nat Genet, 2009
We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant).
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