Up-Regulation of FGF23 Release by Aldosterone.
Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
The present study explored a putative aldosterone sensitivity of Fgf23 transcription and secretion and the putative involvement of the aldosterone sensitive serum & glucocorticoid inducibe kinase SGK1 and SGK1 sensitive transcription factor NFκB and store operated Ca(2+) entry (SOCE).
Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.
Madrid, Spain. In Plos One, Dec 2015
Relative kidney weight, collagen content, fibronectin, macrophage infiltrate, CTGF, Col I, MMP2, TNF-α, CD68, Arg2, and SGK-1 were increased (p<0.05) in aldosterone + salt-treated rats, being reduced by spironolactone (p<0.05).