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Secreted frizzled-related protein 5

SFRP5, secreted frizzled-related protein 5
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Frizzled, SFRP1, SFRP2, WIF1, APC
Papers on SFRP5
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.
Ushijima et al., Tokyo, Japan. In Mol Carcinog, Feb 2016
Regarding individual pathways affected in ESCCs, the WNT pathway was activated potentially by aberrant methylation of its negative regulators, such as SFRP1, SFRP2, SFRP4, SFRP5, SOX17, and WIF1 (33%).
Coevolutionary patterning of teeth and taste buds.
Streelman et al., London, United Kingdom. In Proc Natl Acad Sci U S A, Dec 2015
sfrp5 and bmper, notable for roles in Wingless (Wnt) and bone morphogenetic protein (BMP) signaling, were differentially expressed across cichlid species with divergent tooth and taste bud density, and were expressed in the development of both organs in mice.
The WNT/β-catenin signaling pathway may be involved in granulosa cell apoptosis from patients with PCOS in North China.
Zhang et al., Taiyuan, China. In J Gynecol Obstet Biol Reprod (paris), Nov 2015
RT-qPCR was used to measure mRNA levels of WNT family members (WNT1, WNT3, WNT4, WNT5, sFRP4 and sFRP5).
Angiotensin II increases secreted frizzled-related protein 5 (sFRP5) expression through AT1 receptor/Rho/ROCK1/JNK signaling in cardiomyocytes.
Li et al., Shijiazhuang, China. In Mol Cell Biochem, Oct 2015
Secreted frizzled-related protein 5 (sFRP5) is a novel adipokine that functions as an inhibitor of Wnt signaling and is involved in embryonic development, proliferation, atherosclerosis, and apoptosis.
SFRP5 hepatic expression is associated with non-alcoholic liver disease in morbidly obese women.
Canizales-Quinteros et al., Mexico. In Ann Hepatol, Sep 2015
BACKGROUND AND AIMS: Secreted frizzled-related protein 5 (SFRP5) was recently described as a new adipokine protective for hepatic steatosis and other obesity-related complications in the mouse model.
Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma.
Lu et al., Beijing, China. In World J Gastroenterol, Jun 2015
Methylation sensitive restriction enzyme-quantitative PCR was used to explore the methylation status of CpG islands located in the promoters of APC, SFRP1, and SFRP5 in HCCs with different risk factors.
Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet.
Koza et al., West Scarborough, United States. In Biochimie, Jun 2015
UNASSIGNED: The expression of a subset of genes including mesoderm specific transcript (Mest), secreted frizzled-related protein 5 (Sfrp5) and bone morphogenetic protein 3 (Bmp3) in adipose tissue biopsies of C57BL/6J mice before exposure to an obesogenic diet were shown to be predictive for the development of obesity in mice after feeding a high fat diet for 8 weeks.
Gene methylation profiles as prognostic markers in ovarian clear cell and endometrioid adenocarcinomas.
Cheng et al., Taipei, Taiwan. In Am J Transl Res, 2014
Those with methylation of more than two out of three genes (E-cadherin, DLEC1, and SFRP5) had a shorter disease-free survival (1.89 [1.07-3.32],
Deregulation of secreted frizzled-related proteins is associated with aberrant β-catenin activation in the carcinogenesis of oral submucous fibrosis.
Zhang et al., Shanghai, China. In Onco Targets Ther, 2014
To better elucidate the mechanisms of SFRPs involved in the carcinogenesis of oral submucous fibrosis (OSF), one of the precancerous lesions of oral squamous cell carcinoma (OSCC), we investigated expression and localization of SFRP1, SFRP5, and β-catenin in normal oral epithelium, OSF, and OSCC tissues.
An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.
Walsh et al., Boston, United States. In Nat Med, 2014
In mice, VEGF-A165b expression was upregulated by conditions associated with impaired limb revascularization, including leptin deficiency, diet-induced obesity, genetic ablation of the secreted frizzled-related protein 5 (Sfrp5) adipokine and transgenic overexpression of Wnt5a in myeloid cells.
Secreted frizzled-related protein promotors are hypermethylated in cutaneous squamous carcinoma compared with normal epidermis.
Pu et al., Ürümqi, China. In Bmc Cancer, 2014
RESULTS: The methylation rate of SFRP1, SFRP2, SFRP4, and SFRP5 promoters was significantly higher in cutaneous SCC tissues than in adjacent tissue and normal skin samples.
Declined plasma sfrp5 concentration in patients with type 2 diabetes and latent autoimmune diabetes in adults.
Chen et al., Chongqing, China. In Pak J Med Sci, 2014
OBJECTIVE: Secreted frizzled-related protein 5 (sfrp5), like adiponectin, has been identified as a novel insulin-sensitising and anti-inflammatory adipokine.
Obesity, inflammation, and lung injury (OILI): the good.
Wang, Buffalo, United States. In Mediators Inflamm, 2013
To sum up, the majority of evidence supported that adiponectin, omentin, and secreted frizzled-related protein 5 (SFRP5) were reduced significantly in obesity, which is associated with increased inflammation, indicated by increase of TNF α and IL-6, through activation of toll-like receptor (TLR4) and nuclear factor light chain κ B (NF- κ B) signaling pathways.
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
Michon et al., Helsinki, Finland. In Dev Cell, 2012
early progeny of Sox2-positive stem cells transiently expressed the Wnt inhibitor Sfrp5
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.
Macdougald et al., Ann Arbor, United States. In J Clin Invest, 2012
SFRP5 inhibits WNT signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity.
Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects.
Laudes et al., Kiel, Germany. In Plos One, 2011
Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects
Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer.
Nakao et al., Nagoya, Japan. In Hepatogastroenterology, 2011
significant decrease in the expression of SFRP1 and SFRP5 was observed in gastric cancer compared with corresponding normal gastric tissues
WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors.
Lo Muzio et al., Foggia, Italy. In Oncol Rep, 2010
This study suggests that a cause of catenin delocalization in oral cancer could be due to WNT pathway activation, by epigenetic alterations of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes
Genetic and epigenetic alteration in gastric carcinogenesis.
Machado et al., Porto, Portugal. In Helicobacter, 2010
Several genes have been newly associated with gastric carcinogenesis, both through oncogenic activation (MYC, SEMA5A, BCL2L12, RBP2 and BUBR1) and tumor suppressor gene inactivation mechanisms (KLF6, RELN, PTCH1A, CLDN11, and SFRP5).
Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity.
Walsh et al., Boston, United States. In Science, 2010
data show Sfrp5 is an anti-inflammatory adipokine whose expression is perturbed in models of obesity and type 2 diabetes; in obesity, Sfrp5 secretion exerts salutary effects on metabolic dysfunction by controlling adipose tissue inflammatory cells
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