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Secreted frizzled-related protein 2

SFRP2, secreted frizzled-related protein 2
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Frizzled, SFRP1, SFRP5, DKK1, WIF1
Papers on SFRP2
Early detection of colorectal cancer: from conventional methods to novel biomarkers.
Salehi et al., Eşfahān, Iran. In J Cancer Res Clin Oncol, Feb 2016
In particular, DNA methylation markers (e.g., SEPT9, SFRP2, and ALX4), circulating microRNAs (e.g., microRNA21), SNPs in microRNAs binding site (e.g., rs4596 located within a target region of the predicted miR-518a-5p and miR-527), protein markers (e.g., carcinoembryonic antigen, N-methyltransferase), or microsatellites instability in tumors with deficient mismatch repair of some genes are among the most interesting and promising biomarkers.
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.
Ushijima et al., Tokyo, Japan. In Mol Carcinog, Feb 2016
Regarding individual pathways affected in ESCCs, the WNT pathway was activated potentially by aberrant methylation of its negative regulators, such as SFRP1, SFRP2, SFRP4, SFRP5, SOX17, and WIF1 (33%).
SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment.
Xu et al., Shanghai, China. In Oncogene, Feb 2016
Here we show that the secreted frizzled-related protein 2 (SFRP2), a Wnt pathway modulator, is produced by human primary fibroblasts after genotoxic treatments.
β-catenin, a transcription factor activated by canonical Wnt signaling, is expressed in sensory neurons of calves latently infected with bovine herpesvirus 1.
Jones et al., Lincoln, United States. In J Virol, Feb 2016
During dexamethasone-induced reactivation from latency, mRNA expression levels of two Wnt antagonists, dickkopf1 (DKK1) and secreted frizzled protein 2 (SFRP2), were induced in bovine TG, which correlated with reduced β-catenin protein expression in TG neurons six hours after dexamethasone treatment.
Secreted Frizzled-Related Protein 2 (sFRP2) Functions as a Melanogenic Stimulator; the Role of sFRP2 in UV-Induced Hyperpigmentary Disorders.
Kang et al., Suwŏn, South Korea. In J Invest Dermatol, Jan 2016
In this study, we found that secreted frizzled-related protein 2 (sFRP2) is overexpressed in the hyperpigmentary skin of melasma and solar lentigo and in acutely UV-irradiated skin.
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling.
Yamaguchi et al., Los Angeles, United States. In World J Stem Cells, Jan 2016
The largest increases in CXCL5 expression were seen from stimulation with sFRP1 or sFRP2.
[Fecal Biomarker for Colorectal Cancer Diagnosis].
Matsumura et al., In Rinsho Byori, Mar 2015
DNA mutation of APC, KRAS, and TP53 genes and DNA methylation of VIM, TFPI2, BMP3, NDRG4, and SFRP2 genes were reported as fecal DNA biomarkers.
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma.
Yao et al., Tokyo, Japan. In Int J Clin Exp Pathol, 2014
Wnt signaling is activated by SFRP2 promoter hypermethylation and HH signaling is activated by the frequent mutations in PTCH1.
Accuracy of early detection of colorectal tumours by stool methylation markers: a meta-analysis.
Zhu et al., Wuhan, China. In World J Gastroenterol, 2014
Pooled diagnostic performance of SFRP2 methylation for CRC provided the following results: the sensitivity was 79% (95%CI: 75%-82%), the specificity was 93% (95%CI: 90%-96%), the diagnostic OR was 47.57 (95%CI: 20.08-112.72), the area under the curve was 0.9565.
[Markers for non-invasive molecular genetic diagnosis of oncourological diseases].
Sivkov et al., In Urologiia, 2014
Aberrant methylation of the 5'-regulatory regions of tumor suppressor genes, integrated in the panel, also is considered as a tool in the diagnosis of RC (VHL, RASSF1, RARB2, CDH1), PCa (GSTP1, PTGS2, LGALS3) and BC (RASSF1, APC, SFRP2) after standardization of panels of loci investigated, sample preparation methods, bisulfite conversion, and the design of primers and probes.
Alterations in promoter methylation status of tumor suppressor HIC1, SFRP2, and DAPK1 genes in prostate carcinomas.
Gultekin et al., Sivas, Turkey. In Dna Cell Biol, 2012
Promoter hypermethylation of tumor suppressor SFRP2 is associated with prostate carcinoma.
Change in gene expression profiles of secreted frizzled-related proteins (SFRPs) by sodium butyrate in gastric cancers: induction of promoter demethylation and histone modification causing inhibition of Wnt signaling.
Lee et al., Seoul, South Korea. In Int J Oncol, 2012
Sodium butyrate may modulate the SFRP1/2 expression through histone modification and promoter demethylation causing anti-tumor effects in gastric neoplasms.
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells.
Arenas et al., Stockholm, Sweden. In Stem Cells, 2012
SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells.
Epigenetic inactivation of secreted frizzled-related protein 2 in esophageal squamous cell carcinoma.
Zhang et al., Beijing, China. In World J Gastroenterol, 2012
Data suggest that silencing of secreted frizzled-related protein 2 expression through promoter hypermethylation may be a factor in ESCC carcinogenesis through loss of its tumor-suppressive activity.
The role of secreted frizzled-related protein 2 expression in prostate cancer.
Kay et al., Dublin, Ireland. In Histopathology, 2011
there is a loss of SFRP-2 expression from benign to malignant prostate glands and differential SFRP-2 expression among two possible subgroups of Gleason grade 5 tumours
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction.
Sato et al., New York City, United States. In Nat Cell Biol, 2009
This study thus uncovers a function for sFRP2 and a potential therapeutic application for sFRP2 antagonism in controlling fibrosis in the infarcted heart.
Axial patterning in cephalochordates and the evolution of the organizer.
Holland et al., Los Angeles, United States. In Nature, 2007
In addition, Wnt-antagonists (for example, Dkks and sFRP2-like) are expressed anteriorly, whereas Wnt genes themselves are expressed posteriorly, consistent with a role for Wnt signalling in anterior/posterior (A/P) patterning.
Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases.
De Robertis et al., Los Angeles, United States. In Cell, 2006
Furthermore, mouse sFRP2 inhibited Xlr, suggesting a wider role for this molecular mechanism.
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Torres et al., Córdoba, Spain. In J Clin Oncol, 2005
A group of five genes (SYK-1, ASPP-1, sFRP-2, sFRP-5, and WIF-1) showed specificity for T-ALL compared with B-ALL.
Methylation changes in faecal DNA: a marker for colorectal cancer screening?
Widschwendter et al., Innsbruck, Austria. In Lancet, 2004
identified SFRP2 methylation as a sensitive single DNA-based marker for identification of colorectal cancer in stool samples
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