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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Secreted frizzled-related protein 1

SFRP1, Activin, FRP, SFRP4, EDF
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, Frizzled, V1a, HAD, NODAL
Papers using SFRP1 antibodies
Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum
Lane Nancy E et al., In Journal of Bone and Mineral Research, 2007
... sFRP1 transgenic mice (Tg) PCR product ...
Papers on SFRP1
Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma.
Ushijima et al., Tokyo, Japan. In Mol Carcinog, Feb 2016
Regarding individual pathways affected in ESCCs, the WNT pathway was activated potentially by aberrant methylation of its negative regulators, such as SFRP1, SFRP2, SFRP4, SFRP5, SOX17, and WIF1 (33%).
The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone.
Sofikitis et al., In Hormones (athens), Feb 2016
Activin A, follistatin and FSH control germ cell development.
Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice.
Babitt et al., Reggio nell'Emilia, Italy. In Endocrinology, Feb 2016
Recently, the TGF-β/BMP superfamily member Activin B was implicated in hepcidin induction by inflammation via noncanonical SMAD1/5/8 signaling, but its mechanism of action and functional significance in vivo remain uncertain.
Activin A and follistatin during the oestrous cycle and early pregnancy in ewes.
Juengel et al., New Zealand. In J Endocrinol, Feb 2016
The mRNAs encoding FST and activin A (inhibin beta A subunit, INHBA) were present in the uterus and abundant in the uterine luminal or glandular epithelia by day 18 of gestation.
Atypical Activin A and IL-10 Production Impairs Human CD16+ Monocyte Differentiation into Anti-Inflammatory Macrophages.
Sánchez-Torres et al., Mexico. In J Immunol, Feb 2016
The preferential proinflammatory skewing of M16 relative to M14 was found to be mediated by the secretion of activin A and the low levels of IL-10 produced by M16.
Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders.
Shore et al., Philadelphia, United States. In Cytokine Growth Factor Rev, Jan 2016
UNASSIGNED: Activin receptor-like kinase-2 (ALK2), the product of ACVR1, is a member of the type I bone morphogenetic protein (BMP) receptor family.
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling.
Yamaguchi et al., Los Angeles, United States. In World J Stem Cells, Jan 2016
Dose- (0-500 ng/mL) and time-response curves were generated for treatment with sFRP1.
Granting Immunity to FOP and Catching Heterotopic Ossification in the Act.
Shore et al., Philadelphia, United States. In Semin Cell Dev Biol, Jan 2016
In all affected individuals, FOP is caused by heterozygous missense gain-of-function mutations in Activin receptor A type I (ACVR1), a bone morphogenetic protein (BMP) type I receptor.
Development of New Therapeutic Agents for Fibrodysplasia Ossificans Progressiva.
Hao et al., Pomona, United States. In Curr Mol Med, Dec 2015
The causative heterozygous genetic mutations have been identified in either the intracellular glycine-serine-rich (GS) domain or kinase domain of ALK2 (Activin-like kinase-2, also known as Activin A receptor type I, ACVR1), a type I receptor of bone morphogenetic proteins (BMP).
Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and Progression.
Lin et al., Taipei, Taiwan. In Asian Pac J Cancer Prev, 2014
The transforming growth factor β (TGFβ) superfamily is a large group of structurally related proteins including TGFβ subfamily members Nodal, Activin, Lefty, bone morphogenetic proteins (BMPs) and growth and differentiation factor (GDF).
NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency.
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2014
We induced mesoderm in human pluripotent stem cells with ACTIVIN and BMP or with GSK3-β inhibition.
A method to recapitulate early embryonic spatial patterning in human embryonic stem cells.
Brivanlou et al., New York City, United States. In Nat Methods, 2014
Inhibitory signals limited the range of BMP4 signaling to the colony edge and induced a gradient of Activin-Nodal signaling that patterned mesendodermal fates.
PTP1B is an effector of activin signaling and regulates neural specification of embryonic stem cells.
Sun et al., Brno, Czech Republic. In Cell Stem Cell, 2014
During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate.
Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo.
Deng et al., Shenzhen, China. In Cell Stem Cell, 2013
Here, we report a stepwise protocol to direct the differentiation of hESCs into thymic epithelial progenitor-like cells (TEPLCs) by mimicking thymus organogenesis with sequential regulation of Activin, retinoic acid, BMP, and WNT signals.
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Rosengren et al., Malmö, Sweden. In Cell Metab, 2012
One of the module genes that was highly overexpressed in islets from T2D patients is SFRP4, which encodes secreted frizzled-related protein 4. SFRP4 expression correlated with inflammatory markers, and its release from islets was stimulated by interleukin-1β.
Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.
Schneyer et al., Springfield, United States. In Am J Physiol Endocrinol Metab, 2012
No differences were observed in fasting glucose/insulin levels, glucose tolerance, insulin sensitivity, or insulin secretion in comparing young or older males on in comparing insulin secretion from islets of wild type or activin B knockout males.
Identification of follistatin-like 1 by expression cloning as an activator of the growth differentiation factor 15 gene and a prognostic biomarker in acute coronary syndrome.
Wollert et al., Hannover, Germany. In Clin Chem, 2012
identified FSTL1 as an independent prognostic biomarker in ACS.
High levels of activin A detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting nodal signaling.
Wang et al., Chaoyang, China. In J Clin Endocrinol Metab, 2012
Plasma and placental productions of Activin A were significantly higher in preeclamptic patients when compared with normal pregnant subjects in a Chinese Han population
Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling.
Coppin et al., Toulouse, France. In Blood, 2012
There is a dramatic induction of Inhbb mRNA, encoding the activin beta(B)-subunit, in liver challenged with lipopolysaccharide, slightly preceding an increase in Smad1/5/8 phosphorylation and Hamp mRNA.
Single nucleotide polymorphisms in sFRP4 are associated with bone and body composition related parameters in Danish but not in Belgian men.
Van Hul et al., Antwerp, Belgium. In Mol Genet Metab, 2012
genetic variation in sFRP4 has an influence on hip fracture risk, percentage body fat and height in a Danish male population. However, we were unable to replicate these results in an independent Belgian population.
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