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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nuclear receptor subfamily 5, group A, member 1

SF-1, steroidogenic factor 1, MK2, MEK2, Kv1.2
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, MAPK, p38, V1a, HAD
Papers using SF-1 antibodies
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
Najbauer Joseph, In PLoS ONE, 2008
... in the study are as follows: CRAF, pAKT, AKT, ERK2, p-ERK1/2 (Thr202/Tyr204), MEK1, MEK2 and p-MEK1/MEK2 (Ser217/221) (Cell Signaling Technology, Beverly, MA); BRAF ...
Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways
Kanthou Chryso, In PLoS ONE, 1999
... Antibodies for phospho-p38 MAPK, phospho-cofilin, cofilin, phospho-LIMK, LIMK, phospho-MAPKAPK2 (MK2) and MK2 were purchased from Cell Signaling Technology Inc ...
Papers on SF-1
KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: Support for electrically-active myelin in mammalian saltatory conduction.
Nagy et al., Colorado, Brazil. In J Neurophysiol, Feb 2016
Here, we visualize, identify, localize, quantify, and ultrastructurally-characterize axonal KV1.1/KV1.2
Steroids and genes related to steroid biosynthesis in the female giant freshwater prawn, Macrobrachium rosenbergii.
Sretarugsa et al., Bangkok, Thailand. In Steroids, Feb 2016
Moreover, we identified for the first time the presence of steroidogenic factor 1, StAR-related lipid transfer protein, estradiol receptor- and progesterone-like protein in M. rosenbergii.
Sox3 binds to 11β-hydroxysteroid dehydrogenase gene promoter suggesting transcriptional interaction in catfish.
Senthilkumaran et al., Hyderābād, India. In J Steroid Biochem Mol Biol, Feb 2016
∼2kb of 5' upstream region of 11β-hsd, was cloned from catfish genomic DNA library and in silico promoter analysis revealed putative TF binding sites such as Sox3, Wt1, Pax2, Dmrt1 and Ad4BP/SF-1.
Alterations in Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-Induced Diabetic Rats: Effects of Trigonella foenum-graecum Extract and Swimming Training.
Doost Mohammadpour et al., Īlām, Iran. In Can J Diabetes, Feb 2016
METHODS: We divided 70 male Wistar rats equally into 7 groups: diabetic control (DC), healthy control (HC), swimming (S), fenugreek seed extract (1.74 g/kg) (F1), fenugreek seed extract (0.87 g/kg) (F2), swimming + fenugreek seed extract (1.74 g/kg) (SF1), and swimming + fenugreek seed extract (0.87 g/kg) (SF2).
The episodic ataxia type 1 mutation I262T alters voltage-dependent gating and disrupts protein biosynthesis of human Kv1.1 potassium channels.
Tang et al., Taipei, Taiwan. In Sci Rep, Dec 2015
I262T also exerts similar dominant effects on the gating of Kv1.2 and Kv1.4 channels.
Aldosterone-producing adrenocortical carcinoma with prominent hepatic metastasis diagnosed by liver biopsy: a case report.
Utsunomiya et al., Tokyo, Japan. In Bmc Endocr Disord, Dec 2015
In inoperable cases, aldosterone-producing ACC diagnosed by immunohistochemical staining of the metastatic tumor for Cytochrome P450 (CYP) 11β has not previously been reported and even in that case staining for adrenocortical-specific adrenal 4 binding protein/steroidogenic factor1 (Ad4BP/SF1) and steroidogenic enzymes has not been reported.
A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy.
Yaffe et al., Cambridge, United States. In Cancer Cell, Nov 2015
In p53-mutant tumors, cell cycle checkpoints are rewired, leading to dependency on the p38/MK2 pathway to survive DNA-damaging chemotherapy.
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.
Cook et al., Cambridge, United Kingdom. In Nat Rev Cancer, Oct 2015
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive growth factor-independent ERK1 and ERK2 activation and thence inappropriate cell proliferation and survival.
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
Gil et al., Tübingen, Germany. In Nat Cell Biol, Sep 2015
Here we report a mechanism by which mTOR controls the SASP by differentially regulating the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1.
DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease.
Achermann et al., London, United Kingdom. In Best Pract Res Clin Endocrinol Metab, Aug 2015
DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development.
Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1.
Taniguchi et al., Asahikawa, Japan. In Zoolog Sci, Aug 2015
Steroidogenic factor-1 (SF-1) and liver receptor homolog-1 (LRH-1) belong to the nuclear receptor superfamily and are categorized as orphan receptors.
A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.
Reinhardt et al., Köln, Germany. In Cell, Aug 2015
Here, we perform a cell-line-based screen and identify strong synergistic interactions between cell-cycle checkpoint-abrogating Chk1- and MK2 inhibitors, specifically in KRAS- and BRAF-driven cells.
De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy.
Lemke et al., Leipzig, Germany. In Nat Genet, Apr 2015
Using next-generation sequencing, we identified four different de novo mutations in KCNA2, encoding the potassium channel KV1.2, in six isolated patients with epileptic encephalopathy (one mutation recurred three times independently).
Transcriptional regulation of genes related to progesterone production.
Miyamoto et al., Fukui, Japan. In Endocr J, 2014
Members of the nuclear receptor 5A (NR5A) family (steroidogenic factor 1 and liver receptor homolog 1) play a crucial role in the transcriptional regulation of these genes.
Hypothalamic control of brown adipose tissue thermogenesis.
Richard et al., Québec, Canada. In Front Syst Neurosci, 2014
We also reviewed the involvement of the brain melanocortin and endocannabinoid systems as well as the emerging role of steroidogenic factor 1 (SF1) neurons in BAT thermogenesis.
A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer.
Lu et al., Guangzhou, China. In Am J Hum Genet, 2012
A functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer
Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial.
Messersmith et al., Nashville, United States. In Lancet Oncol, 2012
Define the maximum tolerated dose and recommended phase 2 dose of MEK1/2 inhibitor trametinib and to assess its safety, pharmacokinetics, pharmacodynamics, and response rate in individuals with advanced solid tumours.
Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial.
Fecher et al., Houston, United States. In Lancet Oncol, 2012
Data show substantial clinical activity of MEK1/2 inhibitor trametinib in melanoma and suggest that MEK is a valid therapeutic target.
Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.
Ingraham et al., San Francisco, United States. In Sci Signal, 2012
Data show that inositol polyphosphate multikinase (IPMK) interacts with the nuclear receptor steroidogenic factor 1 (SF-1) and phosphorylates its bound ligand Phosphatidylinositol 4,5-bisphosphate (PIP).
Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve hyperexcitability in type 2 diabetes mellitus.
Chrast et al., Lausanne, Switzerland. In J Neurosci, 2012
This study indicated that the T2DM condition leads to potassium channel-mediated peripheral nerve hyperexcitability , thus identifying them as a potential drug target to treat some of the DPN related symptoms.
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