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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sestrin 3

Top mentioned proteins: Ros, V1a, PA26, FOXO3a, CAN
Papers on SESN3
Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways.
Shen et al., Singapore, Singapore. In Autophagy, May 2015
Moreover, we found that FOXO1-mediated autophagy is achieved via its transcriptional activation, leading to a dual effect on autophagy induction: (i) enhanced expression of autophagy-related (ATG) genes, and (ii) suppression of MTOR via transcription of the SESN3 (sestrin 3) gene.
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.
Petretto et al., Bonn, Germany. In Nat Commun, 2014
In the TLE patients, we map the trans-acting genetic control of this proconvulsive module to Sestrin 3 (SESN3), and demonstrate that SESN3 positively regulates the module in macrophages, microglia and neurons.
The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.
Schweiger et al., Berlin, Germany. In Cell Death Dis, 2013
We integrated the RNA-Seq results with DNA-binding sites of BRD4 generated by chromatin immunoprecipitations, correlated these with gene expressions from human prostate cancers and identified 21 top BRD4 candidate genes among which the oxidative stress pathway genes KEAP1, SESN3 and HDAC6 are represented.
1,25-Dihydroxyvitamin D3 and the aging-related forkhead box O and sestrin proteins in osteoblasts.
Verstuyf et al., Leuven, Belgium. In J Steroid Biochem Mol Biol, 2013
1,25(OH)2D3 rapidly and strongly induced the expression of SESN1 and FoxO3a but down-regulated the expression of SESN3 and FoxO1.
Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1 pathways.
Kopnin et al., Moscow, Russia. In Cell Cycle, 2013
Recently it was shown that repression of SESN1 and SESN3 genes, whose protein products control regeneration of peroxiredoxins, can play a critical role in Ras-induced ROS upregulation.
Transdifferentiation of mesenchymal stem cells-derived adipogenic-differentiated cells into osteogenic- or chondrogenic-differentiated cells proceeds via dedifferentiation and have a correlation with cell cycle arresting and driving genes.
Ringe et al., Berlin, Germany. In Differentiation, 2013
Interestingly, gene profiling and bioinformatics demonstrated that upregulation (DHCR24, G0S2, MAP2K6, SESN3) and downregulation (DST, KAT2, MLL5, RB1, SMAD3, ZAK) of distinct genes have an association with cell cycle arrest in adipogenic-differentiated cells and perhaps narrow down the lineage potency.
Mitochondria and FOXO3: breath or die.
Ausserlechner et al., Innsbruck, Austria. In Front Physiol, 2012
Importantly, FOXO3 simultaneously also activates ROS-detoxification via induction of SESN3.
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
Platanias et al., Chicago, United States. In Plos One, 2012
We provide evidence that in BCR-ABL expressing cells, treatment with tyrosine kinase inhibitors (TKIs) results in upregulation of mRNA levels and protein expression of sestrin3 (SESN3), a unique cellular inhibitor of mTOR complex 1 (mTORC1).
FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3.
Ausserlechner et al., Innsbruck, Austria. In J Cell Sci, 2012
FOXO3 also activated a ROS rescue pathway by inducing the peroxiredoxin SESN3 (Sestrin3), which is responsible for the biphasic ROS accumulation.
Efficient downregulation of multiple mRNA targets with a single shRNA-expressing lentiviral vector.
Chumakov et al., Moscow, Russia. In Plasmid, 2010
The vector system was used for successful simultaneous suppression of three related SESN1, SESN2 and SESN3 genes, which suggests its particular value for testing phenotypes of functionally redundant genes.
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Hay et al., Chicago, United States. In Dev Cell, 2010
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers.
Powell et al., Saint Louis, United States. In Clin Cancer Res, 2007
RESULTS: DMH and COBRA identified two CpG islands methylated in tumors but not in normal DNAs: SESN3 (PY2B4) and TITF1 (SC77F6/154).
Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability.
Chumakov et al., Moscow, Russia. In Cancer Res, 2007
Introduction of oncogenic RAS resulted in repression of transcription from sestrin family genes SESN1 and SESN3, which encode antioxidant modulators of peroxiredoxins.
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