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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Septin 6

SEP2, SEPT2, SEPT6, Nedd5, septin 2, SEPT11, septin 6
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SEP3, MEN, Actin, selenoprotein P, CAN
Papers on SEP2
Efficacy and safety of phosphodiesterase type 5 (PDE5) inhibitors in treating erectile dysfunction after bilateral nerve-sparing radical prostatectomy.
Gao et al., Yantai, China. In Andrologia, Feb 2016
P < 0.00001]; successful vaginal penetration (SEP2) [the odds ratio (OR) = 14.87, 95%CI = 4.57-48.37,
An Overview of Alternating Electric Fields Therapy (NovoTTF Therapy) for the Treatment of Malignant Glioma.
Wong et al., Boston, United States. In Curr Neurol Neurosci Rep, Jan 2016
Based on these criteria, at least two protein complexes have been proposed as TTFields' molecular targets, including α/β-tubulin and the septin 2, 6, 7 heterotrimer.
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts.
Sahai et al., London, United Kingdom. In Cell Rep, Jan 2016
Furthermore, depletion of SEPT2 has similar effects to those of loss of Cdc42EP3, indicating a role for the septin network in the tumor stroma.
Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment - Comparative proteomic study.
Dziedzicka-Wasylewska et al., Kraków, Poland. In Neuroscience, Jan 2016
Both antipsychotics influenced the level of microtubule-regulating proteins, i.e., stathmin, and proteins of the collapsin response mediator protein family (CRMPs), and only CLO affected NAD-dependent protein deacetylase sirtuin-2 and septin 6.
From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Ratti et al., Milano, Italy. In Biochim Biophys Acta, Dec 2015
In particular, TDP-43 and FUS were found to regulate splicing and expression of genes related to neuronal (SEPT6, SULT4A1, TNIK) and RNA metabolism (DICER, ELAVL3/HuC, POLDIP3).
A novel 2q37 microdeletion containing human neural progenitors genes including STK25 results in severe developmental delay, epilepsy, and microcephaly.
Carvalho et al., Boston, United States. In Am J Med Genet A, Nov 2015
The deleted segment contains genes that are highly expressed in the developing human cortical plate and the subventricular zone (SVZ) in vivo and human neural progenitors in vitro, including SEPT2, THAP4, ATG4B, PPP1R7, and STK25.
Gated entry into the ciliary compartment.
Verhey et al., Ann Arbor, United States. In Cell Mol Life Sci, Nov 2015
For membrane proteins, the septin protein SEPT2 is part of the barrier to entry whereas the gating function is carried out and/or regulated by proteins associated with ciliary diseases (ciliopathies) such as nephronophthisis, Meckel-Gruber syndrome and Joubert syndrome.
The Proteomic Analysis of Human Placenta with Pre-eclampsia and Normal Pregnancy.
Kim et al., Suwŏn, South Korea. In J Korean Med Sci, Jun 2015
In preeclamptic placenta 9 differentially expressed proteins were down-regulated with Hsp 70, serum albumin crystal structure chain A, lamin B2, cytokeratin 18, actin cytoplasmic, alpha fibrinogen precursor, septin 2, dihydrolipoamide branched chain transacylase E2 and firbrinogen beta chain.
Degradation of class E MADS-domain transcription factors in Arabidopsis by a phytoplasmal effector, phyllogen.
Namba et al., Tokyo, Japan. In Plant Signal Behav, 2014
While it was shown that phyllogens target some MADS TFs, including SEP3 for degradation, it is unknown whether the other SEPs (SEP1, SEP2, and SEP4) of Arabidopsis are also degraded by them.
Avanafil for the treatment of erectile dysfunction. An updated review.
Martínez-Salamanca et al., Madrid, Spain. In Arch Esp Urol, 2014
In all these studies, avanafil demonstrated a statistically significant improvement in erectile function (IIEF), and all the coprimary outcomes (SEP2 and SEP3) compared to placebo.
Avanafil for male erectile dysfunction: a systematic review and meta-analysis.
Zhang et al., Beijing, China. In Asian J Androl, 2014
Among the co-primary efficacy end points indicating that avanafil 100 mg was more effective than a placebo were successful vaginal penetration (SEP2) (the odds ratio (OR) =5.06, 95% confidence interval (CI) =3.29-7.78,
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Self assembly of human septin 2 into amyloid filaments.
Ulian Araújo et al., São Carlos, Brazil. In Biochimie, 2012
The results shown in study support the hypothesis that single Septin 2, when present in excess or with unbalanced stoichiometries, may be unstable and assemble into amyloid-like structures.
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Peterson et al., San Francisco, United States. In Nat Cell Biol, 2012
A transmembrane component, TMEM231, localizes to the basal body before and independently of intraflagellar transport in a Septin 2 (Sept2)-regulated fashion.
Septin1 is required for spindle assembly and chromosome congression in mouse oocytes.
Sun et al., Beijing, China. In Dev Dyn, 2011
Results show that septin1 is a key player in spindle assembly and chromosome congression in mouse meiosis.
Lethal phenotype of mice carrying a Sept11 null mutation.
Zieger et al., Freiburg, Germany. In Biol Chem, 2011
SEPT11 is involved in vesicle trafficking and may play a role in synaptic connectivity. Interestingly, mice that harbor a homozygous Sept11 null mutation, die in utero.
Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration.
Lah et al., Atlanta, United States. In Mol Neurodegener, 2010
The proteomic discovery of insoluble SEPT11 accumulation in FTLD-U, along with novel pathological associations, highlights a role for this cytoskeleton-associated protein in the pathogenesis of this complex disorder.
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.
Nelson et al., Stanford, United States. In Science, 2010
findings show SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium
Structural insight into filament formation by mammalian septins.
Wittinghofer et al., Dortmund, Germany. In Nature, 2007
crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex
Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
Macara et al., Charlottesville, United States. In Cell, 2007
Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response.
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