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SELK selenoprotein K

SelK, HSP30, Selenoprotein K
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HSP70, Ethanolaminephosphotransferase, ACID, CAN, HAD
Papers on SelK
Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation.
Kim et al., Kwangju, South Korea. In J Biol Chem, Jan 2016
Selenoprotein K (SelK) is another known p97(VCP)-binding selenoprotein, and the expression of both SelS and SelK is increased under ER stress.
The small heat shock protein, HSP30, is associated with aggresome-like inclusion bodies in proteasomal inhibitor-, arsenite-, and cadmium-treated Xenopus kidney cells.
Heikkila et al., Waterloo, Canada. In Comp Biochem Physiol A Mol Integr Physiol, Nov 2015
In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions.
Selenoprotein K and protein palmitoylation.
Hoffmann et al., Honolulu, United States. In Antioxid Redox Signal, Nov 2015
SIGNIFICANCE: Selenoprotein K (SelK) is an endoplasmic reticulum (ER) membrane protein, and its expression is sensitive to dietary selenium levels.
The evolving versatility of selenium in biology.
Brigelius-Flohé, Potsdam, Germany. In Antioxid Redox Signal, Nov 2015
By this mechanism, selenoprotein K (SelK) supports palmitoylation of membrane-associated proteins.
Overexpression of Selenoprotein SelK in BGC-823 Cells Inhibits Cell Adhesion and Migration.
Chen et al., Shenyang, China. In Biochemistry (mosc), Oct 2015
Effects of human selenoprotein SelK on the adhesion and migration ability of human gastric cancer BGC-823 cells using Matrigel adhesion and transwell migration assays, respectively, were investigated in this study.
Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks.
Shan et al., Harbin, China. In Biol Trace Elem Res, Oct 2015
The mRNA levels of 14 selenoprotein genes (Dio1, Dio2, GPx3, Sepp1, SelH, SelI, SelK, Sepn1, SelO, SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (GPx1, GPx2, GPx4, SelPb, Txnrd1, Txnrd2, Txnrd3, SPS2, and SelM) increased in L group (p < 0.05), but the Dio3 and Sepx1 mRNA levels did not change.
Selenium deficiency influences nitric oxide and selenoproteins in pancreas of chickens.
Xu et al., Harbin, China. In Biol Trace Elem Res, 2014
The correlation analysis suggested that NO had a strong negative correlation with GPX1, glutathione peroxidase 2 (GPX2), GPX3, DIO1, selenoprotein K (SELK), SELI, SEPX1, and SPS2.
Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex.
Hoffmann et al., Mannheim, Germany. In Proc Natl Acad Sci U S A, 2014
Previous studies demonstrated that genetic deletion of selenoprotein K (Selk) led to decreased Ca(2+) flux in a variety of immune cells and impaired immunity, but the mechanism was unclear.
Selective up-regulation of human selenoproteins in response to oxidative stress.
Laurent et al., France. In Free Radic Biol Med, 2014
Furthermore, in response to oxidative stress, we identified a selective upregulation of several selenoproteins involved in antioxidant defense (Gpx1, Gpx4, TR1, SelS, SelK and Sps2).
Transcriptional response of Saccharomyces cerevisiae to potassium starvation.
van Heusden et al., Leiden, Netherlands. In Bmc Genomics, 2013
Genes involved in stress response including HSP30, YRO2 and TPO2 and phosphate metabolism including PHO84, PHO5 and SPL2 were highly up-regulated.
Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.
Gladyshev et al., Boston, United States. In J Biol Chem, 2012
Data suggest that SelK is involved in the Derlin-dependent ERAD of glycosylated misfolded proteins and that the function defined by the prototypic SelK is the widespread function of selenium in eukaryotes.
Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages.
Hoffmann et al., Honolulu, United States. In J Biol Chem, 2011
Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor 2,3,4 and 9-induced calpastatin in macrophages
Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses.
Hoffmann et al., Honolulu, United States. In J Immunol, 2011
Sel K-deficient T cells exhibit decreased chemokine receptor-mediated calcium flux.
Heat shock protein gene expression and function in amphibian model systems.
Heikkila, Waterloo, Canada. In Comp Biochem Physiol A Mol Integr Physiol, 2010
For example, while hsp70 genes are heat-inducible after the midblastula stage, hsp30 genes are not inducible until late neurula/early tailbud.
Selenoproteins and maternal nutrition.
Zervas et al., Athens, Greece. In Comp Biochem Physiol B Biochem Mol Biol, 2008
Sel include but not limited to glutathione peroxidases (GPx1-GPx6), thioredoxin reductases (TrxR1-TrxR3), iodothyronine deiodinases (ID1-ID3), selenophosphate synthetase 2 (SPS2), 15-kDa Sel (Sel15), SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelR, SelS, SelT, SelV, SelW, as well as the 15-kDa Sel (Fep15), SelJ and SelU found in fish.
Identification and characterization of selenoprotein K: an antioxidant in cardiomyocytes.
Peng et al., Beijing, China. In Febs Lett, 2006
SelK is a novel antioxidant in cardiomyocytes and is related to the regulation of cellular redox balance.
Regulation and function of small heat shock protein genes during amphibian development.
Heikkila, Waterloo, Canada. In J Cell Biochem, 2004
For example, in Xenopus, the shsp gene family, hsp30, is repressed and not heat-inducible until the late neurula/early tailbud stage whereas other hsps are inducible at the onset of zygotic genome activation at the midblastula stage.
Expression and function of small heat shock protein genes during Xenopus development.
Heikkila, Waterloo, Canada. In Semin Cell Dev Biol, 2003
The hsp30 small heat shock protein family is a stress-inducible group of molecular chaperones in the frog, Xenopus laevis.
Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.
Sherman et al., Rochester, United States. In Nat Genet, 1999
Furthermore, DNA microarray analysis of BTN1 and btn1-delta strains revealed differential expression of two genes, with at least one, HSP30, involved in pH control.
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