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EPH receptor A4

SEK, EphA4
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Eph, CAN, JNK, V1a, AP-1
Papers using SEK antibodies
The New S Language: A Programming Environment for Data Analysis and Graphics;
Zhang Lin, In PLoS ONE, 1997
... the following proteins were used: rabbit anti-EphA2 (Life Technologies/Zymed Laboratories, Carlsbad, CA; clone 347400); rabbit anti-EphA4 (Lifespan Biosciences, Seattle, WA; clone ...
Papers on SEK
Coulthard et al., South Brisbane, Australia. In Shock, Feb 2016
We hypothesized that blocking Eph/ephrin signaling using an EphA4-Fc would result in decreased inflammation and tissue injury in a model of ischemia/reperfusion (I/R) injury.
Desipramine targets astrocytes to attenuate synaptic plasticity via modulation of the ephrinA3/EphA4 signalling.
Di Benedetto et al., München, Germany. In Neuropharmacology, Feb 2016
These effects correlated with a reduced neuronal activation in the stratum pyramidale, thereby prompting us to analyse a regulator of LTP located at the astrocyte-neuron interface in the stratum radiatum, namely the ephrinA3/EphA4 signalling pathway.
Glyphosate induces neurotoxicity in zebrafish.
Ochs et al., Fairfield, United States. In Environ Toxicol Pharmacol, Feb 2016
Concomitant with structural changes in the developing brain, using in situ hybridization analysis, we detect decreases in genes expressed in the eye, fore and midbrain regions of the brain including pax2, pax6, otx2 and ephA4.
C-Terminal Auto-Regulatory Motif of Hepatitis C Virus NS5B Interacts with Human VAPB-MSP to Form a Dynamic Replication Complex.
Song et al., Singapore, Singapore. In Plos One, Dec 2015
The identification that EphA2 and EphA5 bind to the MSP domain with higher affinity than EphA4 provides a biophysical basis for further exploring whether other than inducing ALS-like syndrome, the HCV infection might also trigger pathogenesis associated with signalling pathways mediated by EphA2 and EphA5.
Plant alkaloids as drug leads for Alzheimer's disease.
Ip et al., Hong Kong, Hong Kong. In Neurochem Int, Oct 2015
Interestingly, rhynchophylline, a known neuroprotective alkaloid, was recently discovered by in silico screening as an inhibitor of EphA4, a novel target for AD.
Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions.
Mundlos et al., Berlin, Germany. In Cell, Jun 2015
We show that distinct human limb malformations are caused by deletions, inversions, or duplications altering the structure of the TAD-spanning WNT6/IHH/EPHA4/PAX3 locus.
Are we using the right pharmacological tools to target EphA4?
Lodola et al., Parma, Italy. In Acs Chem Neurosci, 2015
The EphA4 receptor has been proposed to be a key actor in neurodegenerative diseases.
Activation of EphA4 and EphB2 Reverse Signaling Restores the Age-Associated Reduction of Self-Renewal, Migration, and Actin Turnover in Human Tendon Stem/Progenitor Cells.
Docheva et al., München, Germany. In Front Aging Neurosci, 2014
Here, we report for the first time the significant downregulation of the ephrin receptors EphA4, EphB2 and B4 and ligands EFNB1 in aged-TSPC (A-TSPC).
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.
Weinberg et al., Cambridge, United States. In Nat Cell Biol, 2014
We performed quantitative proteomic profiling and found that the EMT program upregulates the expression of CD90, also known as Thy1, and EphA4, which mediate the physical interactions of CSCs with TAMs by directly binding with their respective counter-receptors on these cells.
Syntrophin proteins as Santa Claus: role(s) in cell signal transduction.
Khanday et al., Jammu, India. In Cell Mol Life Sci, 2013
They play an important role in regulating the postsynaptic signal transduction, sarcolemmal localization of nNOS, EphA4 signaling at the neuromuscular junction, and G-protein mediated signaling.
Eph/Ephrin signaling in injury and inflammation.
Boyd et al., Australia. In Am J Pathol, 2012
In rodent spinal cord injury, the up-regulation of EphA4 prevents recovery by inhibiting axons from crossing the injury site.
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Robberecht et al., Leuven, Belgium. In Nat Med, 2012
Epha4 modulates the vulnerability of motor neurons to axonal degeneration and may represent a new target for therapeutic intervention in ALS.
Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons.
Zhang et al., Taiyuan, China. In Neurosci Lett, 2012
Blocking ephrinA3/EphA4 interaction by EphA4-Fc, an inhibitor of EphA4, attenuated apoptotic neuronal cell death, likely through the inhibition of caspase-3 activation
Genetic evidence for a contribution of EphA:ephrinA reverse signaling to motor axon guidance.
Klein et al., Martinsried, Germany. In J Neurosci, 2012
we provide evidence for a role of EphA:ephrinA attractive reverse signaling in motor axon guidance and in vivo evidence of in-parallel forward Eph and reverse ephrin signaling function in the same neuronal population
Expression and activation of EphA4 in the human brain after traumatic injury.
Goldshmit et al., Melbourne, Australia. In J Neuropathol Exp Neurol, 2012
The present study demonstrates that EphA4 is expressed on neurons in multiple regions of the intact human brain and is markedly upregulated on activated astrocytes after TBI
Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein.
Shaham et al., New York City, United States. In Science, 2012
pqn-41 expression is controlled by the mitogen-activated protein kinase kinase SEK-1, which functions in parallel to the zinc-finger protein LIN-29 to promote cellular demise.
Bidirectional ephrinB3/EphA4 signaling mediates the segregation of medial ganglionic eminence- and preoptic area-derived interneurons in the deep and superficial migratory stream.
Bolz et al., Jena, Germany. In J Neurosci, 2012
cell contact-mediated bidirectional ephrinB3/EphA4 signaling mediates the sorting of medial ganglionic eminence- and preoptic area-derived interneurons in the deep and superficial migratory stream.
A review of published reports on neuroprotection in spinal cord injury.
von Wild et al., Bucureşti, Romania. In Spinal Cord, 2009
RESULTS: There have been identified many molecules, primarily expressed by heterogenous glial and neural subpopulations of cells, which are directly or indirectly critical for tissue damaging/sparing/re-growth inhibiting, angiogenesis and neural plasticity, and also various substances/energy vectors with regenerative properties, such as MAG (myelin-associated glycoprotein), Omgp (oligodendrocyte myelin glycoprotein), KDI (synthetic: Lysine-Asparagine-Isoleucine 'gamma-1 of Laminin Kainat Domain'), Nogo (Neurite outgrowth inhibitor), NgR (Nogo protein Receptor), the Rho signaling pathway (superfamily of 'Rho-dopsin gene-including neurotransmitter-receptors'), EphA4 (Ephrine), GFAP (Glial Fibrillary Acidic Protein), different subtypes of serotonergic and glutamatergic receptors, antigens, antibodies, immune modulators, adhesion molecules, scavengers, neurotrophic factors, enzymes, hormones, collagen scar inhibitors, remyelinating agents and neurogenetic/plasticity inducers, all aiming to preserve/re-establish the morphology and functional connections across the lesion site.
Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling.
Marquardt et al., Los Angeles, United States. In Science, 2008
in axial nerves, establishment of discrete afferent & efferent pathways depends on signaling between coextending sensory & motor projections; the axon-axon interactions require motor axonal EphA3/EphA4 activated by cognate sensory axonal ephrin-A ligands
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