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SEC12 Sec12p

sec12, preB, Sec12p
WD-repeat containing regulatory transcription factor; may mediate gene transcription in the pituitary and in other organs [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, V1a, CD45, BCR, ACID
Papers on sec12
Prolactin regulatory element binding protein is involved in hepatitis C virus replication compartment by interacting with NS4B.
Aizaki et al., Tokyo, Japan. In J Virol, Feb 2016
Subsequent small interfering RNA screening in replicon cells identified prolactin regulatory element binding (PREB) as a novel HCV host cofactor.
Essential control of early B-cell development by Mef2 transcription factors.
Stocking et al., Hamburg, Germany. In Blood, Jan 2016
The preB-cell receptor (preBCR) is an important checkpoint of B-cell development and essential for a preB-cell to traverse into an immature B-cell.
Quantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and re-sensitization by JNK inhibition.
Irving et al., Innsbruck, Austria. In Br J Haematol, Nov 2015
A proteomic approach was used to compare profiles of the B-lineage ALL GC-sensitive cell line, PreB 697, and its GC-resistant sub-line, R3F9, pre- and post-dexamethasone exposure.
A dietary dairy/yeast prebiotic and flaxseed oil enhance growth, hematological and immunological parameters in channel catfish at a suboptimal temperature (15°C).
Sink et al., Pine Bluff, United States. In Animal, Jul 2015
A 28%-protein basal diet was supplemented with 20 g/kg cellulose and 20 g/kg soybean oil (SBO, control), 20 g/kg cellulose and 20 g/kg flaxseed oil (FLAX) or 20 g/kg of a dairy/yeast prebiotic and 20 g/kg soybean oil (PREB).
Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals.
Fauci et al., Los Angeles, United States. In J Immunol, Apr 2015
Increased frequencies of plasma cells, as well as B cell precursors, namely preB-I and preB-II, and decreased frequencies of mature B cells were observed in bone marrow aspirates of these individuals compared with HIV-negative counterparts.
Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate.
Ishida et al., Japan. In Atherosclerosis, 2010
PREB regulates the cAMP-mediated transcription of the ABCA1 gene in vascular smooth muscle cells
The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells.
Ishida et al., Japan. In Endocrine, 2010
PREB can function as a transcriptional regulator of prolactin promoter activity and might be involved in TRH-induced PRL gene transcription
Prolactin regulatory element-binding protein involved in cAMP-mediated suppression of adiponectin gene.
Ishida et al., Japan. In J Cell Mol Med, 2010
PREB may contribute to the regulation of ApN gene transcription, in response to cAMP activation in adipocytes.
The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.
Ishida et al., Japan. In Atherosclerosis, 2009
The transcriptional factor PREB mediates MCP-1 transcription induced by cytokines in human vascular endothelial cells.
The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.
Ishida et al., Japan. In Biochem Biophys Res Commun, 2008
These data showed that in the adrenal gland, PREB regulates the transcription of the CYP11B1 gene via cAMP.
The pre-B cell receptor and its function during B cell development.
Lu et al., Hong Kong, Hong Kong. In Cell Mol Immunol, 2004
During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage.
Mechanisms of selection mediated by interleukin-7, the preBCR, and hemokinin-1 during B-cell development.
Paige et al., Toronto, Canada. In Immunol Rev, 2004
Following the expression of the preB-cell receptor (preBCR), cells acquire the ability to proliferate in low levels of interleukin-7 (IL-7), which acts as a self-selecting mechanism to expand cells that have successfully expressed a preBCR in environments that are non-permissive to preBCR- cells.
Selection events in directing B cell development.
Melamed et al., Haifa, Israel. In Histol Histopathol, 2003
It is now clear that most of these signals require the expression of B cell antigen receptor (or preB receptor) with functional signaling capacity.
The role of the preBCR, the interleukin-7 receptor, and homotypic interactions during B-cell development.
Paige et al., Toronto, Canada. In Immunol Rev, 2000
We propose that one function of stromal cells, known to be central to B lymphopoiesis, is to promote critical preB-preB homotypic interactions and ensuing signals.
Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells.
Andersson et al., Basel, Switzerland. In Immunol Rev, 2000
A spectrum of affinities between VpreB and individual V(H) domains generates preB cells with pre-BCR of different fitness which, in turn, determines the extent of the pre-B II-cell proliferation and the fidelity of allelic exclusion of the H chain locus.
The Ig alpha/Igbeta heterodimer on mu-negative proB cells is competent for transducing signals to induce early B cell differentiation.
Karasuyama et al., Tokyo, Japan. In Immunity, 1997
When RAG-2-deficient mice were treated with anti-Ig beta monoclonal antibody, developmentally arrested proB cells were induced to differentiate to the small preB cell stage as observed when the mu transgene was expressed in RAG-2-deficient mice.
Changes in the V(H) gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor.
Rolink et al., Basel, Switzerland. In Immunity, 1997
Representation of the D-proximal V(H) genes was found suppressed on the productive but not on the nonproductive V(H)DJ(H) rearranged alleles of c-kit preB-II cells and splenic lambda5-deficient B cells.
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement.
Winkler et al., Basel, Switzerland. In Immunity, 1995
Expression levels are high in D-->JH and VH-->DJH rearranging proB and preB-I cells, low in preB cells expressing the preB cell receptor on the cell surface, and high again in VL-->JL rearranging small preB-II cells.
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.
Cosson et al., Basel, Switzerland. In Cell, 1995
Whereas retrieval was unaffected in most sec mutants tested (sec7, sec12, sec13, sec16, sec17, sec18, sec19, sec22, and sec23), a defect in retrieval was observed in previously characterized coatomer mutants (sec21-1, sec27-1), as well as in newly isolated retrieval mutants (sec21-2, ret1-1).
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER.
Schekman et al., Berkeley, United States. In Nature, 1993
In yeast a type II integral membrane glycoprotein that is essential for transport vesicle budding from the endoplasmic reticulum (ER) is encoded by SEC12 (refs 1-3).
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