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Succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa

This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SDH, CAN, VHL, HAD, RET
Papers on SDHC
Efficacy of SDHI fungicides including benzovindiflupyr against Colletotrichum species.
Schnabel et al., Tsukuba, Japan. In Pest Manag Sci, Feb 2016
The sdhB, sdhC and sdhD genes encoding the subunits of fungicide-targeted succinate dehydrogenase were sequenced but despite high polymorphisms, no apparent resistance mutations were found in Colletotrichum species.
Mechanism of neem limonoids-induced cell death in cancer: Role of oxidative phosphorylation.
Chandra et al., Buffalo, United States. In Free Radic Biol Med, Jan 2016
Complex II-deficiency due to the loss of succinate dehydrogenase complex subunit C (SDHC) robustly decreased caspase activation, apoptosis, and cell death.
Epigenetic mutation of the succinate dehydrogenase C promoter in a patient with two paragangliomas.
Eisenhofer et al., Dresden, Germany. In J Clin Endocrinol Metab, Jan 2016
Epigenetic inactivation of the SDHC gene is a more recently discovered phenomenon, which so far has only been described in GISTs and PPGLs from patients with Carney triad syndrome.
Renal carcinoma associated with a novel succinate dehydrogenase A mutation: a case report and review of literature of a rare subtype of renal carcinoma.
Netto et al., ─░stanbul, Turkey. In Hum Pathol, Dec 2015
Renal cell carcinoma (RCC) linked to germline mutation of succinate dehydrogenase subunits A, B, C, and D (SDHA, SDHB, SDHC, and SDHD, respectively) has been recently included as a provisional entity in the 2013 International Society of Urological Pathology Vancouver classification.
Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis.
Maebashi et al., Tokyo, Japan. In Antimicrob Agents Chemother, Dec 2015
All of the laboratory-generated resistant mutants tested harbored a mutation in one of the subunits of succinate dehydrogenase (SdhB, SdhC, or SdhD).
A novel RET gene mutation in a patient with apparently sporadic pheochromocytoma.
Pellegriti et al., Catania, Italy. In Endocr J, Nov 2015
The recent discovery of new germline mutations in RET, SDHA, SDHB, SDHC, SDHD, VHL, NF1, TMEM127, MAX genes, increased the rate of genetic disease from 10% to 28% in patients with apparently sporadic tumor.
Ghayee et al., Dallas, United States. In Endocr Pract, Nov 2015
OBJECTIVE: To describe a patient with a germline SDHC mutation presenting with primary hyperparathyroidism and a large catecholamine producing temporal bone paraganglioma (PGL).
15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1-5.
Clifton-Bligh et al., Sydney, Australia. In Endocr Relat Cancer, Aug 2015
PGL3 syndrome (SDHC) and PGL5 syndrome (SDHA) are less common and appear to be associated with lower penetrance of tumour development.
How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models.
Lambin et al., Maastricht, Netherlands. In Mutat Res Rev Mutat Res, Apr 2015
succinate dehydrogenase (SDHB, SDHC and SDHD genes) and iso-citrate dehydrogenase (IDH1 and IDH2 genes).
Paraganglioma and phaeochromocytoma: from genetics to personalized medicine.
Gimenez-Roqueplo et al., Paris, France. In Nat Rev Endocrinol, Feb 2015
DNA methylation profiling has uncovered a hypermethylator phenotype in tumours related to SDHx genes (a group of genes comprising SDHA, SDHB, SDHC, SDHD and SDHAF2) and revealed that succinate acts as an oncometabolite, inhibiting 2-oxoglutarate-dependent dioxygenases, such as hypoxia-inducible factor prolyl-hydroxylases and histone and DNA demethylases.
[Hereditary pheochromocytoma-associated syndromes. Part 1].
Beltsevich et al., In Ter Arkh, 2014
There have been the most investigated NF, RET, VHL, SDHD, SDHC, and SDHB gene mutations.
Somatic mutation analysis of the SDHB, SDHC, SDHD, and RET genes in the clinical assessment of sporadic and hereditary pheochromocytoma.
Erlic et al., Freiburg, Germany. In Horm Cancer, 2012
Tumor DNA mutation screening of the SDHx, VHL, and RET genes and LOH analyses of the SDHx and VHL genes were performed for pheochromocytoma.
Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3.
Neumann et al., Freiburg, Germany. In Endocr Relat Cancer, 2012
Biallelic inactivation of the SDHC gene may represent a new pathway of pathogenesis of syndromic and nonsyndromic renal cell carcinoma, perhaps of both clear cell and papillary histologies
Synchronous carotid body and thoracic paraganglioma associated with a germline SDHC mutation.
Berguer et al., Ann Arbor, United States. In J Vasc Surg, 2011
Case Report: present a 32-year-old man with a familial SDHC mutation who manifests synchronous paragangliomas of the carotid body and the thoracic aortopulmonary window.
Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species.
Spitz et al., Iowa City, United States. In Radiat Res, 2011
mammalian cells over expressing mutations in SDHC demonstrate low-dose/low-LET radiation sensitization that is mediated by increased levels of O*- and HO.
Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes.
Clifton-Bligh et al., Sydney, Australia. In Hum Pathol, 2010
Approximately 15% of all pheochromocytomas or paragangliomas are associated with germline SDH mutation.
SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma.
Robledo et al., Leiden, Netherlands. In Lancet Oncol, 2010
BACKGROUND: Paragangliomas and phaeochromocytomas are neuroendocrine tumours associated frequently with germline mutations of SDHD, SDHC, and SDHB.
An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis.
Dinjens et al., Rotterdam, Netherlands. In Lancet Oncol, 2009
This syndrome is caused by germline mutations in succinate dehydrogenase B (SDHB), C (SDHC), or D (SDHD) genes.
Von Hippel-Lindau disease.
Kaelin, Boston, United States. In Annu Rev Pathol, 2006
pVHL, by inhibiting atypical protein kinase C and hence JunB, also affects neuronal survival, as do the products of the other genes linked to familial pheochromocytoma or paraganglioma (NF1, RET, SDHB, SDHC, and SDHD).
Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene.
European-American Paraganglioma Study Group et al., Padova, Italy. In Jama, 2005
CONTEXT: Paraganglioma syndrome includes inherited head and neck paragangliomas (HNPs) and adrenal or extra-adrenal pheochromocytomas and are classified according to the susceptibility genes SDHB, SDHC, and SDHD.
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