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Succinate dehydrogenase complex, subunit B, iron sulfur

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, SDHC, HAD, VHL
Papers using SDH antibodies
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
Miettinen Markku et al., In Journal of Cancer, 2005
... Immunostaining was performed with Leica Bond-Max automatic immunostainer (Leica, Bannockburn, IL) using a commercially available SDHB mouse monoclonal antibody 21A11 (Abcam ab14714, Cambridge, MA) ...
Papers on SDH
Managing Subdural Bleeding Associated With Rivaroxaban: A Series of 3 Cases.
Denetclaw et al., Dallas, United States. In J Pharm Pract, Feb 2016
CASE SUMMARIES: Case 1 presented with a 1-cm thick subdural hematoma (SDH) 12 hours after her last dose of rivaroxaban.
Efficacy of SDHI fungicides including benzovindiflupyr against Colletotrichum species.
Schnabel et al., Tsukuba, Japan. In Pest Manag Sci, Feb 2016
The sdhB, sdhC and sdhD genes encoding the subunits of fungicide-targeted succinate dehydrogenase were sequenced but despite high polymorphisms, no apparent resistance mutations were found in Colletotrichum species.
A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold.
Norton et al., Australia. In Structure, Feb 2016
Solution structure determination revealed a unique peptide fold that we have designated the single disulfide-directed β hairpin (SDH).
Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.
Rouault et al., Bethesda, United States. In Cell Metab, Jan 2016
Here, we demonstrate that SDHAF1 contributes to iron-sulfur (Fe-S) cluster incorporation into the Fe-S subunit of CII, SDHB.
Renal carcinoma associated with a novel succinate dehydrogenase A mutation: a case report and review of literature of a rare subtype of renal carcinoma.
Netto et al., İstanbul, Turkey. In Hum Pathol, Dec 2015
Renal cell carcinoma (RCC) linked to germline mutation of succinate dehydrogenase subunits A, B, C, and D (SDHA, SDHB, SDHC, and SDHD, respectively) has been recently included as a provisional entity in the 2013 International Society of Urological Pathology Vancouver classification.
[Inhibitory effect of Genipin on uncoupling protein-2 and energy metabolism of androgen-independent prostate cancer cells].
Xia et al., In Zhonghua Nan Ke Xue, Nov 2015
Then the proliferation of the cells was detected by MTT assay, the expression of UCP-2 mRNA determined by RT-PCR, and the content of intracellular pyruvic acid (PA) and the activity of succinate dehydrogenase (SDH) in the mitochondria measured by visible spectrophotometry.
Metastatic pheochromocytoma and paraganglioma.
Kaltsas et al., Athens, Greece. In Eur J Clin Invest, Sep 2015
Germline succinate dehydrogenase complex, subunit B (SDHB) mutation constitutes the main reliable molecular predictor of malignancy.
15 YEARS OF PARAGANGLIOMA: Clinical manifestations of paraganglioma syndromes types 1-5.
Clifton-Bligh et al., Sydney, Australia. In Endocr Relat Cancer, Aug 2015
PGL4 syndrome (SDHB) is notable for an increased risk of malignant PGL or PC.
[Hereditary pheochromocytoma-associated syndromes. Part 1].
Beltsevich et al., In Ter Arkh, 2014
There have been the most investigated NF, RET, VHL, SDHD, SDHC, and SDHB gene mutations.
[Succinate dehydrogenase-deficient tumors--a novel mechanism of tumor formation].
Miettinen, In Duodecim, 2014
Succinate dehydrogenase (SDH) is a heterotetrameric enzyme complex participating in the Krebs cycle and electron transfer of oxidative phosphorylation.
Transposon Mutagenesis Identifies Novel Genes Associated with Staphylococcus aureus Persister Formation.
Zhang et al., Shanghai, China. In Front Microbiol, 2014
We found 13 insertion mutants with significantly lower persister numbers under several stress conditions, including sdhA, sdhB, ureG, mnhG1, fbaA, ctaB, clpX, parE, HOU_0223, HOU_0587, HOU_2091, HOU_2315, and HOU_2346, which mapped into pathways of oxidative phosphorylation, TCA cycle, glycolysis, cell cycle, and ABC transporters, suggesting that these genes and pathways may play an important role in persister formation and survival.
SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.
Rutter et al., Salt Lake City, United States. In Cell Metab, 2014
Sdh8 interacts specifically with the catalytic Sdh1 subunit in the mitochondrial matrix, facilitating its association with Sdh2 and the subsequent assembly of the SDH holocomplex.
The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.
Winge et al., Salt Lake City, United States. In Cell Metab, 2014
We show here that two factors, Sdh6 (SDHAF1) and Sdh7 (SDHAF3), mediate maturation of the FeS cluster SDH subunit (Sdh2/SDHB).
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase.
Rasola et al., Padova, Italy. In Cell Metab, 2013
TRAP1 binds to and inhibits succinate dehydrogenase (SDH), the complex II of the respiratory chain.
Influence of metabolism on epigenetics and disease.
McKnight et al., Boston, United States. In Cell, 2013
This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, FH, and IDH can result in cancer and, more broadly, for how alterations in metabolism and nutrition might contribute to disease.
Genetic and clinical characteristics of head and neck paragangliomas in a Chinese population.
Gao et al., Tianjin, China. In Laryngoscope, 2012
The high frequency of founder mutations in SDHB suggests a higher prevalence of malignancy, and the SDHD mutation is usually associated with familial cases.
Somatic mutation analysis of the SDHB, SDHC, SDHD, and RET genes in the clinical assessment of sporadic and hereditary pheochromocytoma.
Erlic et al., Freiburg, Germany. In Horm Cancer, 2012
Tumor DNA mutation screening of the SDHx, VHL, and RET genes and LOH analyses of the SDHx and VHL genes were performed for pheochromocytoma.
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.
Guan et al., Shanghai, China. In Genes Dev, 2012
Tumor-derived FH and SDH mutations accumulate fumarate and succinate, leading to enzymatic inhibition of multiple alpha-KG-dependent dioxygenases and consequent alterations of genome-wide histone and DNA methylation.
Prevalence of germline mutations in patients with pheochromocytoma or abdominal paraganglioma and sporadic presentation: a population-based study in Western Sweden.
Wängberg et al., Göteborg, Sweden. In World J Surg, 2012
Analysis of germline mutation frequencies revealed two cases with missense, one case with a splice-site mutation, and six cases of single nucleotide polymorphisms in SDHB gene in pheochromocytoma and abdominal paraganglioma in Western Sweden.
Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations.
Favier et al., Paris, France. In J Clin Endocrinol Metab, 2012
We identified the pathway that distinguishes SDHB-metastatic from all other types of pheochromocytomas/paragangliomas and suggest that activation of the EMT process might play a critical role in the particularly invasive phenotype of this group of tumors.
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