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Synaptonemal complex protein 3

SCP3, SYCP3, synaptonemal complex protein 3, CORI
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, MLH1, HAD, SM22alpha
Papers using SCP3 antibodies
A drying-down technique for the spreading of mammalian meiocytes from the male and female germline
Hawley R Scott, In PLoS Genetics, 1996
... were incubated overnight at 4 °C with the following primary antibodies diluted in PBS: mouse monoclonal anti-SYCP3 (Abcam, 12452) at a 1:100 dilution; ...
Papers on SCP3
The cryptic Y-autosome translocation in the small Indian mongoose, Herpestes auropunctatus, revealed by molecular cytogenetic approaches.
Kuroiwa et al., Tokushima, Japan. In Chromosoma, Feb 2016
To unambiguously identify the Y-bearing autosome, we performed immunostaining of pachytene spermatocytes using antibodies against SYCP3, γH2AX, and the centromere.
Promoting effect of licorice extract on spermatogonial proliferation and spermatocytes differentiation of neonatal mice in vitro.
Jin et al., Jilin, China. In In Vitro Cell Dev Biol Anim, Jan 2016
Furthermore, proteins related to spermatocyte differentiation, synaptonemal complex protein 3 (SCP3) and meiotic recombinant protein Spo11, were detected by immunohistochemical staining.
Protein markers of synaptic behavior and chromatin remodeling of the neo-XY body in phyllostomid bats.
Sciurano et al., Buenos Aires, Argentina. In Chromosoma, Jan 2016
Testicular tissues from adult males of the species Artibeus lituratus, Artibeus planirostris, Uroderma bilobatum, and Vampyrodes caraccioli from the eastern Amazonia were analyzed by optical/electron microscopy and immunofluorescence of meiotic proteins involved in synapsis (SYCP3 and SYCE3), sister-chromatid cohesion (SMC3), and chromatin silencing (BRCA1, γ-H2AX, and RNApol 2).
Bone morphogenetic protein 4 (BMP4) induces buffalo (Bubalus bubalis) embryonic stem cell differentiation into germ cells.
Chauhan et al., Karnāl, India. In Biochimie, Dec 2015
qPCR analysis revealed that BMP4 at a concentration of 50-100 ngml(-1) for a culture period of 14 days led to maximum induction of germ lineage genes like DAZL, VASA, PLZF (PGC-specific); SYCP3, MLH1, TNP1/2 and PRM2 (Meiotic genes); BOULE and TEKT1 (Spermatocyte markers); GDF9, ZP2 and 3 (Oocyte markers).
Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.
Chauhan et al., In Reprod Fertil Dev, Dec 2015
Quantitative polymerase chain reaction analysis revealed that 20%-40% CCM induced the highest expression of primordial germ cell-specific (deleted in Azoospermia- like (Dazl), dead (Asp-Glu-Ala-Asp) box polypeptide 4 (Vasa also known as DDX4) and promyelocytic leukemia zinc finger protein (Plzf)); meiotic (synaptonemal complex protein 3 (Sycp3), mutl homolog I (Mlh1), transition protein 1/2 (Tnp1/2) and protamine 2 (Prm2); spermatocyte-specific boule-like RNA binding protein (Boule) and tektin 1 (Tekt1)) and oocyte-specific growth differentiation factor 9 (Gdf9) and zona pellucida 2 /3 (Zp2/3)) genes over 8-14 days in culture.
CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo.
Huang et al., Guangzhou, China. In Plos One, 2014
SYCP3-like X-linked 2 (SLX2) is a germ cell specific component, which contains a Cor1 domain and belongs to the XLR (X-linked, lymphocyte regulated) family.
The diverse roles of RNA polymerase II C-terminal domain phosphatase SCP1.
Kim et al., Ch'ŏngju, South Korea. In Bmb Rep, 2014
The subfamily includes Small CTD phosphatases, like SCP1, SCP2, SCP3, TIMM50, HSPC129 and UBLCP.
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Kleene, Boston, United States. In Reproduction, 2013
As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood.
Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes.
Pezza et al., Córdoba, Argentina. In Plos Genet, 2012
SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Absence of SYCP3 mutations in women with recurrent miscarriage with at least one trisomic miscarriage.
Robinson et al., Vancouver, Canada. In Reprod Biomed Online, 2012
mutations in SYCP3 do not contribute significantly to risk for recurrent miscarriage through maternal meiotic nondisjunction.
MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia.
Chen et al., Guangzhou, China. In Oncogene, 2012
identified RBSP3, a phosphatase-like tumor suppressor, as a bona fide target of miR-100 and validated that RBSP3 was involved in cell differentiation and survival in acute myeloid leukemia
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
Miyagawa et al., Tokyo, Japan. In Embo Rep, 2012
Expression of SYCP3 inhibits the homologous recombination (HR) pathway mediated by RAD51.
SYCP3 mutation may not be associated with recurrent miscarriage caused by aneuploidy.
Sugiura-Ogasawara et al., Nagoya, Japan. In Hum Reprod, 2011
The 657T>C mutation of SYCP3 may not be associated with recurrent miscarriage caused by aneuploidy.
[Genetics and male infertility].
Lissens et al., Brussels, Belgium. In Verh K Acad Geneeskd Belg, 2008
We also studied five autosomal genes: SYCP3, MSH4, DNMT3L, STRA8 and ETV5.
Isolation and analyses of enriched populations of male mouse germ cells by sedimentation velocity: the centrifugal elutriation.
Bianchi et al., Roma, Italy. In Methods Mol Biol, 2008
In this chapter, we describe the isolation of five mouse germ-cell fractions by centrifugal elutriation, and characterize them by their DNA content (flow cytometry), cell morphology (DAPI staining of nuclei, Giemsa staining of squashed cells) and deposition of stage-specific meiotic markers (SYCP3, H1t, SAM68) on chromosome spreads and whole cells.
[Knockout mice in the service of reproduction].
Escalier, Le Kremlin-Bicêtre, France. In Gynecol Obstet Fertil, 2008
However, due to numerous factors involved, positive results obtained by the "candidate gene approach" remain limited (for example, SCP3 and CREM).
In vitro germline potential of stem cells derived from fetal porcine skin.
Li et al., Guelph, Canada. In Nat Cell Biol, 2006
Some of these aggregates extruded large oocyte-like cells that expressed oocyte markers, such as zona pellucida, and the meiosis marker, synaptonemal complex protein 3 (SCP3).
Germline stem cells and follicular renewal in the postnatal mammalian ovary.
Tilly et al., Boston, United States. In Nature, 2004
Furthermore, we demonstrate cells expressing the meiotic entry marker synaptonemal complex protein 3 in juvenile and adult mouse ovaries.
Azoospermia in patients heterozygous for a mutation in SYCP3.
Lamb et al., Bethesda, United States. In Lancet, 2003
We suggest that SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein via dominant negative interference.
Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3.
Höög et al., Stockholm, Sweden. In Science, 2002
absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation
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