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Sex comb on midleg-like 2

SCML2, sex comb on midleg-like 2
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Polycomb, Histone, PRC1, CDKL5, Scmh1
Papers on SCML2
USP7 cooperates with SCML2 to regulate the activity of PRC1.
Reinberg et al., New York City, United States. In Mol Cell Biol, Apr 2015
Here, we provide evidence that USP7 regulates the activity of Polycomb repressive complex 1 (PRC1) in coordination with SCML2.
SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.
Namekawa et al., Cincinnati, United States. In Dev Cell, Apr 2015
SCML2, a germline-specific subunit of a Polycomb repressive complex 1 (PRC1), establishes the unique epigenome of the male germline through two distinct antithetical mechanisms.
Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.
Wang et al., New York City, United States. In Plos Genet, 2015
Here we report that mouse SCML2 (Sex comb on midleg-like 2), an X chromosome-encoded polycomb protein, is specifically expressed in germ cells, including spermatogonia, spermatocytes, and round spermatids.
Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2).
Bezsonova, Farmington, United States. In J Biol Chem, 2014
Scml2 is a member of the Polycomb group of proteins involved in epigenetic gene silencing.
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
Reinberg et al., New York City, United States. In Plos Biol, 2013
The human SCML2 gene, a mammalian homologue of the Drosophila PcG protein SCM, encodes two protein isoforms: SCML2A that is bound to chromatin and SCML2B that is predominantly nucleoplasmic.
Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.
Reinberg et al., New York City, United States. In Elife, 2013
SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1.
Activated amelogenin Y-linked (AMELY) regulation and angiogenesis in human hepatocellular carcinoma by biocomputation.
Jiang et al., Beijing, China. In Oncol Lett, 2013
The AMELY upstream regulation molecular network model was constructed with BUB1B, CST6, ESM1, HOXA5, LEF1, MAPT, MYBL2, NOTCH3, PLA2G1B, PROK1, ROBO1, SCML2 and UBE2C in HCC from a Gene Expression Omnibus (GEO) dataset by gene regulation network inference methods and our programming methods.
Epileptic encephalopathy in a girl with an interstitial deletion of Xp22 comprising promoter and exon 1 of the CDKL5 gene.
Bienvenu et al., Paris, France. In Am J Med Genet B Neuropsychiatr Genet, 2010
Subsequent analysis on a Nimblegen HD2 microarray confirmed a deletion of approximately 300 kb at Xp22, including the BEND2, SCML2, and CDKL5 genes.
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.
Bycroft et al., Cambridge, United Kingdom. In J Mol Biol, 2008
The malignant brain tumor repeats of SCML2 preferentially bind histone peptides monomethylated at lysine residues. The crystal structure of the complex reveals that the modified amino acid binds to an aromatic rich pocket.
Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.
Ostergaard et al., Ã…rhus, Denmark. In Eur J Haematol, 2008
To analyse the role of deregulated PcG genes in acute myeloid leukaemia (AML), we determined by RQ-PCR the expression of the PcG genes BMI-1, MEL18, SCML2, YY1 and EZH2, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 in diagnostic bone marrow samples from 126 AML patients.
Adaptive evolution of SCML1 in primates, a gene involved in male reproduction.
Su et al., Kunming, China. In Bmc Evol Biol, 2007
When compared with the paralogous genes (SCML2 and SCMH1) of the same family, SCML1 evolved rapidly in primates, which is consistent with the proposed adaptive evolution, suggesting functional modification after gene duplication.
Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).
Bycroft et al., Cambridge, United Kingdom. In J Biol Chem, 2003
1.78-A crystal structure of the two MBT repeats of SCML2 show significant structural similarities to the Tudor, PWWP, and chromo domains, suggesting probable evolutionary relationships and functional similarities between the MBT repeats and these domains.
Refinement of the NHS locus on chromosome Xp22.13 and analysis of five candidate genes.
Franco et al., Tours, France. In Eur J Hum Genet, 2002
Direct sequencing or SSCP analysis of the coding exons of five genes (SCML1, SCML2, STK9, RS1 and PPEF1), considered as candidate genes on the basis of their location in the critical interval, failed to detect any mutation in 12 unrelated NHS patients, thus making it highly unlikely that these genes are implicated in NHS.
Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22.
Franco et al., Milano, Italy. In Genomics, 1999
The newly identified transcript named SCML2 (sex comb on midleg like-2, HGMW-approved symbol) is ubiquitously expressed and encodes a protein of 700 amino acids.
Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1.
Kalscheuer et al., Berlin, Germany. In Genome Res, 1999
Sequencing of 68 kb of Fugu genomic DNA identified nine genes in the following order: (SCML2)-STK9, XLRS1, PPEF-1, KELCH2, KELCH1, PHKA2, AP19, and U2AF1-RS2.
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