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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

KIT ligand

SCF, Stem Cell Factor, C on
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Cullin, CAN, Skp1, V1a
Papers using SCF antibodies
Gene Expression Omnibus
Golub Todd R et al., In Genome Biology, 1998
... Growth factors PDGF, EGF, and SCF were obtained from Cell Signaling [ ...
Bone marrow clones representing an intermediate stage of development between hematopoietic stem cells and pro-T-lymphocyte or pro-B-lymphocyte progenitors
Nishikawa Shin-Ichi et al., In The Journal of Experimental Medicine, 1992
... ) with or without recombinant stem cell factor (rSCF; 100 ng/ml; reference 24) on PRIMARIA culture plates measuring 3.5 cm in diameter (Becton Dickinson Labware, Lincoln Park, NJ) ...
Papers on SCF
Proximate and fatty acid composition of zebra (EQUUS quagga burchellii) muscle and subcutaneous fat.
Cawthorn et al., Stellenbosch, South Africa. In J Sci Food Agric, Feb 2016
This study aimed to determine the proximate composition of zebra meat, as well as the fatty acid composition of the intramuscular (IMF) and subcutaneous (SCF) fat.
Skp2 inhibits osteogensis by promoting ubiquitin-proteasome degradation of Runx2.
Trivedi et al., Lucknow, India. In Biochim Biophys Acta, Feb 2016
Here, for the first time we demonstrate that Skp2, an SCF family E3 ubiquitin ligase negatively targets Runx2 by promoting its polyubiquitination and proteasome dependent degradation.
Ubiquitin ligase Fbw7 restricts the replication of hepatitis C virus by targeting NS5B for ubiquitination and degradation.
Guo et al., Wuhan, China. In Biochem Biophys Res Commun, Feb 2016
The well known tumor suppressor Fbw7, a component of E3 ubiquitin ligase SCF(Fbw7), targets oncoproteins or cellular regulatory proteins for ubiquitin-mediated degradation through a highly conserved binding site called a Cdc4 phosphodegron (CPD).
FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Sun et al., Ann Arbor, United States. In Mol Cell, Feb 2016
SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair.
Delayed application of the haematopoietic growth factors G-CSF/SCF and FL reduces neonatal excitotoxic brain injury.
Griesmaier et al., Innsbruck, Austria. In Brain Res, Feb 2016
The effect of haematopoietic growth factors, such as granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF) and flt-3 ligand (FL) on neonatal brain injury is controversially discussed.
Melatonin, bone regulation and the ubiquitin-proteasome connection: A review.
Reiter et al., Winnipeg, Canada. In Life Sci, Jan 2016
The ubiquitin ligases that are reported to be of major significance in regulating these pathways are the ubiquitin SCF(B-TrCP) ligase (which regulates activation of NF-κB via degradation of IkBα in osteoclasts, and regulates bone transcription factors via degradation of β-catenin), the Keap-Cul3-Rbx1 ligase (which regulates degradation of IkB kinase, Nrf2, and the antiapoptotic factor Bcl-2), and Smurf1.
The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove.
Keijzers et al., Copenhagen, Denmark. In Front Biosci, Dec 2015
Recent studies suggest that Ku80 is conjugated to lysine48-linked ubiquitin chains by the Skp1-Cullin-F-box (SCF) complex and/or the RING finger protein 8 (RNF8) ubiquitin-protein ligases, followed by rapid proteasomal degradation.
The SCF-type E3 Ubiquitin Ligases as Cancer Targets.
Kitagawa et al., Hamamatsu, Japan. In Curr Cancer Drug Targets, Dec 2015
F-box proteins form SCF (SKP1-Cullin1-F-box protein)-type ubiquitin (E3) ligases to selectively target their substrates for degradation via the ubiquitin-proteasome pathway.
Targeting ubiquitination for cancer therapies.
Zhang et al., Houston, United States. In Future Med Chem, Nov 2015
Special attention will be given to novel inhibitors of E3 ubiquitin ligases, especially those in the SCF family.
Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
He et al., Grand Rapids, United States. In Nature, Oct 2015
In the presence of active jasmonate, JAZ proteins function as jasmonate co-receptors by forming a hormone-dependent complex with COI1, the F-box subunit of an SCF-type ubiquitin E3 ligase.
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.
Sutherland et al., Dundee, United Kingdom. In Biochem Soc Trans, Sep 2015
In the latter case, we speculate that growth factors increase the stability of Nrf2 by stimulating phosphoinositide 3-kinase (PI3K)-protein kinase B (PKB)/Akt signalling, which in turn results in inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) and in doing so prevents the formation of a DSGIS motif-containing phosphodegron in Nrf2 that is recognized by the β-transducin repeat-containing protein (β-TrCP) Cul1-based E3 ubiquitin ligase complex SCF(β-TrCP).
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
Pagano et al., New York City, United States. In Nat Cell Biol, 2015
We show that the intercentrosomal linker protein Cep68 is degraded in prometaphase through the SCF(βTrCP) (Skp1-Cul1-F-box protein) ubiquitin ligase complex.
Human RORγt(+)CD34(+) cells are lineage-specified progenitors of group 3 RORγt(+) innate lymphoid cells.
Romagnani et al., Genova, Italy. In Immunity, 2015
In contrast, RORγt(-)CD34(+) HPCs could differentiate to become either ILC3s or natural killer (NK) cells, with differentiation toward ILC3 lineage determined by stem cell factor (SCF) and aryl hydrocarbon receptor (AhR) signaling.
SCF ubiquitin ligase-targeted therapies.
Pagano et al., New York City, United States. In Nat Rev Drug Discov, 2014
F-box proteins are the substrate-targeting subunits of SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complexes.
Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
Bassermann et al., München, Germany. In Nat Med, 2014
FBXO25 encodes an orphan F-box protein that determines the substrate specificity of the SCF (SKP1-CUL1-F-box)(FBXO25) ubiquitin ligase complex.
Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells.
Makino et al., Okayama, Japan. In Mol Cell Endocrinol, 2012
results indicate that KL-c-kit interaction plays a role in estrogenic regulation through oocyte-granulosa cell communication
Stem cell factor programs the mast cell activation phenotype.
Gilfillan et al., Bethesda, United States. In J Immunol, 2012
A major role is described for SCF in the homeostatic control of mast cell activation with potential relevance to mast cell-driven disease and the development of novel approaches for the treatment of allergic disorders.
JCV+ Patients with Inflammatory bowel disease show elevated plasma levels of MIG and SCF.
Zauli et al., Trieste, Italy. In Inflamm Bowel Dis, 2012
Elevated plasma levels of SCF are associated with inflammatory bowel disease with JCV infection.
Rab27b regulates c-kit expression by controlling the secretion of stem cell factor.
Tohyama et al., Kōbe, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that Rab27b negatively regulates the cell surface expression of c-kit via secretion of SCF and that ligation of SCF leads to the endolysosomal degradation system of c-kit.
Involvement of stem cell factor and c-kit in corneal wound healing in mice.
Ohashi et al., Japan. In Mol Vis, 2011
The SCF/c-kit system may play a role in corneal wound healing through epithelial cell attachment.
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