Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.
Madison, United States. In J Lipid Res, Feb 2015
To understand the mechanism by which hepatic MUFA production influences adipose tissue stores, we created two liver-specific transgenic mouse models in the SCD1 knockout that express either human SCD5 or mouse SCD3, that synthesize oleate and palmitoleate, respectively.
In situ characterizing membrane lipid phenotype of breast cancer cells using mass spectrometry profiling.
Beijing, China. In Sci Rep, 2014
The Western blotting assays indicated that the expression of five lipogenesis-related enzymes (i.e., fatty acid synthase 1(FASN1), stearoyl-CoA desaturase 1 (SCD1), stearoyl-CoA desaturase 5 (SCD5), choline kinase α (CKα), and sphingomyelin synthase 1) was associated with the types of the breast cells, and that the SCD1 level in MCF-7 cells was significantly increased relative to other breast cell lines.
Microarrays, antiobesity and the liver.
Guadalajara, Mexico. In Ann Hepatol, 2004
Both models of obesity resistance share many similar phenotypic antiobesity features, however, the perilipin-/- mice had a significant downregulation of stearoyl CoA desaturases scd1 and scd2 in its white adipose tissue, but a normal level of both genes inside the liver, even under high-fat diet.