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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

RAD21 homolog

Scc1, Rad21, nuclear matrix protein 22, DEP-1, Mcd1, CD148
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, NIPBL, ACID
Papers using Scc1 antibodies
A handcuff model for the cohesin complex
Pati Debananda et al., In The Journal of Cell Biology, 2007
... The sources of pAbs used are as follows: Flag (Sigma-Aldrich), Rad21 (Pati et al., 2002), Smc3 (Bethyl Laboratories, Inc.), Smc1α (Santa ...
Signal transduction by VEGF receptors in regulation angiogenesis and lymphangiogenesis
Nör Jacques E. et al., In Cell death and differentiation, 2005
... HDMEC and UM-SCC-1 cells were starved overnight, and treated with 0-50 ng/ml rhEGF, 0-50 ng/ml rhVEGF165, or 0-50 ng/ml rhPlGF (R & D Systems, Minneapolis, MN), 0-50 ng/ml rhVEGF-E (Fitzgerald, Concord, MA), or 0-20 ...
Papers on Scc1
Electrochemical sensing of nuclear matrix protein 22 in urine with molecularly imprinted poly(ethylene-co-vinyl alcohol) coated zinc oxide nanorod arrays for clinical studies of bladder cancer diagnosis.
Lin et al., Kao-hsiung, Taiwan. In Biosens Bioelectron, Feb 2016
UNASSIGNED: In 1996 and 2000, the US Food and Drug Administration (FDA) approved the use of Nuclear matrix protein 22 (NMP22) as a monitoring tool for predicting the recurrence/clearing of bladder cancer, and for screening undiagnosed individuals who have symptoms of, or are at risk for, that disease.
The Cohesin Complex Prevents the End Joining of Distant DNA Double-Strand Ends.
Lopez et al., Villejuif, France. In Mol Cell, Feb 2016
At the genome level, whole-exome sequencing showed that ablation of RAD21 or Sororin produces large chromosomal rearrangements (translocation, duplication, deletion).
Concurrent detection of targeted copy number variants and mutations using a myeloid malignancy next generation sequencing panel allows comprehensive genetic analysis using a single testing strategy.
Kelley et al., Salt Lake City, United States. In Br J Haematol, Feb 2016
The most frequent CNVs were 7q deletion including LUC7L2 and EZH2, TP53 deletion, ETV6 deletion, gain of RAD21 on 8q, and 5q deletion, including NSD1 and NPM1.
Expanding the clinical spectrum of the "HDAC8-phenotype" - Implications for molecular diagnostics, counselling and risk prediction.
Kaiser et al., Lübeck, Germany. In Clin Genet, Jan 2016
Approximately 75% of patients carry a variant in one of the five cohesin-related genes NIPBL, SMC1A, SMC3, RAD21 and HDAC8.
Urinary Biomarkers for Diagnosis of Bladder Cancer: A Systematic Review and Meta-analysis.
Selph et al., In Ann Intern Med, Jan 2016
STUDY SELECTION: 57 studies that evaluated the diagnostic accuracy of quantitative or qualitative nuclear matrix protein 22 (NMP22), qualitative or quantitative bladder tumor antigen (BTA), fluorescence in situ hybridization (FISH), fluorescent immunohistochemistry (ImmunoCyt [Scimedx]), and Cxbladder (Pacific Edge Diagnostics USA) using cystoscopy and histopathology as the reference standard met inclusion criteria.
Cornelia de Lange syndrome.
Tümer et al., Copenhagen, Denmark. In Clin Genet, Jul 2015
To date five genes [NIPBL (Nipped-B-like protein), SMC1A (structural maintenance of chromosomes 1A), SMC3 (structural maintenance of chromosomes 3), RAD21 (human homolog of Schizosaccharomyces pombe radiation sensitive mutant 21) and HDAC8 (histone deacetylase 8)] have been associated with CdLS and mutations of these genes comprise the underlying defect in 70% of the patients.
SMC1B is present in mammalian somatic cells and interacts with mitotic cohesin proteins.
Musio et al., Pisa, Italy. In Sci Rep, 2014
In mammalian cells, the mitotic cohesin complex consists of two structural maintenance of chromosome proteins, SMC1A and SMC3, the kleisin protein RAD21 and a fourth subunit either STAG1 or STAG2.
Identification of novel pathogenic gene mutations in pediatric acute myeloid leukemia by whole-exome resequencing.
Shiba, In Rinsho Ketsueki, 2014
On the other hand, several genes were newly identified in the current study, including BCORL1 and major cohesin components such as SMC3 and RAD21.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Ogawa et al., Tokyo, Japan. In Nat Genet, 2013
Here we report recurrent mutations and deletions involving multiple components of the cohesin complex, including STAG2, RAD21, SMC1A and SMC3, in different myeloid neoplasms.
Cohesin complexes with a potential to link mammalian meiosis to cancer.
Strunnikov, Guangzhou, China. In Cell Regen (lond), 2012
The first reports characterizing the SMC1 and RAD21 genes, encoding subunits of cohesin, were published 20 years ago; however the exact molecular mechanics of cohesin molecular machine in vivo remains rather obscure notwithstanding ample elegant experiments.
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle.
Shirahige et al., Philadelphia, United States. In Nature, 2012
In humans, the multisubunit complex cohesin is made up of SMC1, SMC3, RAD21 and a STAG protein.
Polymorphisms of protein tyrosine phosphatase CD148 influence FcγRIIA-dependent platelet activation and the risk of heparin-induced thrombocytopenia.
Gruel et al., Tours, France. In Blood, 2012
CD148 polymorphisms affect platelet activation and probably exert a protective effect on the risk of Heparin-induced thrombocytopenia in patients with antibodies to PF4/Heparin complexes.
Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.
Yu et al., Dallas, United States. In Genes Dev, 2012
show that the Smc5/6 subunit Mms21 sumoylates multiple lysines of the cohesin subunit Scc1
Meiotic cohesin complexes are essential for the formation of the axial element in mice.
Pendás et al., Salamanca, Spain. In J Cell Biol, 2012
show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L and REC8 were unable to initiate RAD51- but not DMC1-mediated double-strand break repair
RAD21 mutations cause a human cohesinopathy.
Kaiser et al., Philadelphia, United States. In Am J Hum Genet, 2012
RAD21 mutations cause a human cohesinopathy
Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-α gene expression.
Maniatis et al., New York City, United States. In Proc Natl Acad Sci U S A, 2012
Knockdown of Rad21 reduces expression of the constitutive, biallelically expressed Pcdhalpha isoforms alphac1 and alphac2.
Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
Weiss et al., San Francisco, United States. In Immunity, 2011
Here, we report that two RPTPs, CD45 and CD148, previously shown to share redundant roles in positively regulating Src family kinases (SFKs) in immunoreceptor signaling pathways in B cells and macrophages, are critical in the neutrophil response to S. aureus infection and, surprisingly, in chemoattractant-mediated chemotaxis.
Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.
Underhill et al., Los Angeles, United States. In Nature, 2011
In this study we show that, despite its ability to bind both soluble and particulate β-glucan polymers, Dectin-1 signalling is only activated by particulate β-glucans, which cluster the receptor in synapse-like structures from which regulatory tyrosine phosphatases CD45 and CD148 (also known as PTPRC and PTPRJ, respectively) are excluded (Supplementary Fig. 1).
Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.
Weiss et al., San Francisco, United States. In Immunity, 2008
The receptor-type protein tyrosine phosphatase (RPTP) CD148 is thought to have an inhibitory function in signaling and proliferation in nonhematopoietic cells.
Selph et al., Rockville, United States. In Unknown Journal, 0001
RESULTS: Urinary biomarkers were associated with sensitivity for bladder cancer that ranged from 0.57 to 0.82 and specificity from 0.74 to 0.88, for positive likelihood ratios from 2.52 to 5.53 and negative likelihood ratios from 0.21 to 0.48 (strength of evidence [SOE]: moderate for quantitative nuclear matrix protein 22 [NMP22], qualitative bladder tumor antigen [BTA], fluorescence in situ hybridization [FISH], and ImmunoCyt(™); low for other biomarkers).
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