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Secretory carrier membrane protein 3

SCAMP3, propin1
This gene encodes an integral membrane protein that belongs to the secretory carrier membrane protein family. The encoded protein functions as a carrier to the cell surface in post-golgi recycling pathways. This protein is also involved in protein trafficking in endosomal pathways. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: SCAMP1, Epidermal Growth Factor, EGFR, LAMP-1, CCTG
Papers on SCAMP3
Regulation of the MVB pathway by SCAMP3.
Gruenberg et al., Genève, Switzerland. In Traffic, 2012
SCAMP3 has a positive role in sorting into and budding of intralumenal vesicles and thereby controls the process of multivesicular endosome biogenesis.
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Brumell et al., Toronto, Canada. In Cell Microbiol, 2011
Arl8B(+) tubules partially colocalized with LAMP1 and SCAMP3.
Salmonella-induced tubular networks.
Méresse et al., Taipei, Taiwan. In Trends Microbiol, 2011
However, recent studies revealed that the Salmonella-induced tubular network is more extensive than previously thought and includes three types of tubules distinct from SIFs: sorting nexin tubules, Salmonella-induced secretory carrier membrane protein 3 (SCAMP3) tubules and lysosome-associated membrane protein 1 (LAMP1)-negative tubules.
SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking.
Holden et al., London, United Kingdom. In Cell Microbiol, 2009
SCAMP3 tubules reflect a manipulation of specific post-Golgi trafficking that might allow Salmonella to acquire nutrients and membrane, or to control host immune responses.
Phenotypic and molecular evaluation of a chromosome 1q region with linkage and association to type 2 diabetes in humans.
Elbein et al., Little Rock, United States. In J Clin Endocrinol Metab, 2009
PKLR was not expressed in available tissues, but expression of genes HCN3, CLK2, SCAMP3, and FDPS was not associated with haplotype combinations in adipose or muscle.
SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling.
Castle et al., Charlottesville, United States. In Mol Biol Cell, 2009
Depletion of SCAMP3 in HeLa cells by inhibitory RNA accelerated degradation of epidermal growth factor receptor (EGFR) and EGF while inhibiting recycling
Gene expression profiling in hepatocellular carcinoma: upregulation of genes in amplified chromosome regions.
Wilkens et al., Hannover, Germany. In Mod Pathol, 2008
Comparison of significance analysis of microarray and gene set enrichment analysis narrowed down the number of dysregulated genes to 18, with 7 genes localised on 1q22 (SCAMP3, IQGAP3, PYGO2, GPATC4, ASH1L, APOA1BP, and CCT3).
Medullary cystic kidney disease type 1: mutational analysis in 37 genes based on haplotype sharing.
Hildebrandt et al., Ann Arbor, United States. In Hum Genet, 2006
Mutational analysis of all 37 positional candidate genes revealed sequence variations in 3 different genes, AK000210, CCT3, and SCAMP3, that were segregating in each affected kindred and were not found in 96 healthy individuals, indicating, that a single responsible gene causing MCKD1 remains elusive.
Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor.
Castle et al., Charlottesville, United States. In Mol Biol Cell, 1998
In the presence of the tyrosine phosphatase inhibitor vanadate, or after overexpression in Chinese hamster ovary (CHO) cells, SCAMP1 and SCAMP3 are phosphorylated selectively on tyrosine residue(s).
Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease.
Sidransky et al., Bethesda, United States. In Genome Res, 1997
The second gene, propin1, has a 1.5-kb cDNA and shares homology to a rat secretory carrier membrane protein 37 (SCAMP37).
Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions.
Castle et al., Charlottesville, United States. In J Cell Sci, 1997
the SCAMPs may largely function at the same sites during vesicular transport rather than in separate post-Golgi recycling pathways.
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