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Acyl-CoA dehydrogenase, C-2 to C-3 short chain

SCAD, short-chain acyl-CoA dehydrogenase, Butyryl-CoA Dehydrogenase, ACADS
This gene encodes a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, Presenilin-1
Papers on SCAD
The composition and daily variation of microparticles in whole blood in stable coronary artery disease.
Siegbahn et al., Uppsala, Sweden. In Scand J Clin Lab Invest, Feb 2016
INTRODUCTION: The knowledge of circadian variation of microparticles (MPs) in stable coronary artery disease (SCAD) is limited.
Quantitative acylcarnitine determination by UHPLC-MS/MS - Going beyond tandem MS acylcarnitine "profiles".
Hoppel et al., Cleveland, United States. In Mol Genet Metab, Dec 2015
In this report, we present results from the application of our validated UHPLC-MS/MS second-tier method for the quantification of total carnitine, free carnitine, butyrobetaine, and acylcarnitines to patient samples with known diagnoses: malonic acidemia, short-chain acyl-CoA dehydrogenase deficiency (SCADD) or isobutyryl-CoA dehydrogenase deficiency (IBD), 3-methyl-crotonyl carboxylase deficiency (3-MCC) or ß-ketothiolase deficiency (BKT), and methylmalonic acidemia (MMA).
Prolonged CRP Increase After Percutaneous Coronary Intervention Is Associated with High Thrombin Concentrations and Low Platelet' Response to Clopidogrel in Patients with Stable Angina.
Gajos et al., Kraków, Poland. In Adv Clin Exp Med, Nov 2015
However, there is still controversy over invasive versus optimal pharmacological treatment in stable CAD (SCAD).
Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.
Shimkets et al., Athens, United States. In Genes Dev, Oct 2015
Myxococcus xanthus development requires CsgA, a member of the short-chain alcohol dehydrogenase (SCAD) family of proteins.
The importance of ensemble averaging in enzyme kinetics.
Truhlar et al., Barcelona, Spain. In Acc Chem Res, Mar 2015
Systems discussed include hydride transfer in alcohol dehydrogenase, xylose isomerase, and thymidylate synthase, proton transfer in methylamine dehydrogenase, hydrogen atom transfer in methylmalonyl-CoA mutase, and nucleophilic substitution in haloalkane dehalogenase and two-dimensional potentials of mean force for potentially coupled proton and hydride transfer in the β-oxidation of butyryl-coenzyme A catalyzed by short-chain acyl-CoA dehydrogenase and in the pyruvate to lactate transformation catalyzed by lactate dehydrogenase.
A case report of short-chain acyl-CoA dehydrogenase deficiency (SCADD).
Battelino et al., Ljubljana, Slovenia. In Biochem Med (zagreb), 2014
BACKGROUND: Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is a rare inherited mitochondrial fatty acid oxidation disorder associated with variations in the ACADS (Acyl-CoA dehydrogenase, C-2 to C-3 short chain) gene.
Detection of selection signatures in Piemontese and Marchigiana cattle, two breeds with similar production aptitudes but different selection histories.
Macciotta et al., Sassari, Italy. In Genet Sel Evol, 2014
In addition, several new putative candidate genes (for example ALAS1, ABCB8, ACADS and SOD1) were detected.
New Oral Anticoagulants in Coronary Artery Disease.
Akin et al., Mannheim, Germany. In Cardiovasc Hematol Disord Drug Targets, 2014
This review aims to summarize the current guidelinebased recommendations about the use of new oral anticoagulants (NOACs) in patients with stable CAD (SCAD), acute coronary syndromes (ACS), percutaneous coronary interventions (PCI) and in patients with concomitant atrial fibrillation (AF).
Wu et al., Xiamen, China. In Ann Appl Stat, 2013
Regularization regression methods, such as LASSO or SCAD, are then applied to further identify important genetic effects.
Energy conservation via electron bifurcating ferredoxin reduction and proton/Na(+) translocating ferredoxin oxidation.
Thauer et al., Marburg an der Lahn, Germany. In Biochim Biophys Acta, 2013
FBEB has been detected in the clostridial butyryl-CoA dehydrogenase/electron transferring flavoprotein complex (BcdA-EtfBC), the multisubunit [FeFe]hydrogenase from Thermotoga maritima (HydABC) and from acetogenic bacteria, the [NiFe]hydrogenase/heterodisulfide reductase (MvhADG-HdrABC) from methanogenic archaea, and the transhydrogenase (NfnAB) from many Gram positive and Gram negative bacteria and from anaerobic archaea.
Mitochondrial proteomics--a tool for the study of metabolic disorders.
Palmfeldt et al., Århus, Denmark. In J Inherit Metab Dis, 2012
The study of cultured skin fibroblasts from patients with ethylmalonic aciduria associated with variations in the genes coding for short-chain acyl-CoA dehydrogenase (SCAD) or ETHE1 are two of the examples.
Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases.
Gomes et al., Lisbon, Portugal. In Biochim Biophys Acta, 2011
physiological concentrations of flavin adenine dinucleotide resulted in a spectacular enhancement of the thermal stabilities of SCAD and prevented enzymatic activity loss
Phenotypic and mutation spectrums of Thai patients with isovaleric acidemia.
Wasant et al., Bangkok, Thailand. In Pediatr Int, 2011
IVD mutations in Asian populations are distinct from these in Western populations.
Short-Chain Acyl-CoA Dehydrogenase Deficiency
Vockley et al., Seattle, United States. In Unknown Journal, 2011
CLINICAL CHARACTERISTICS: The clinical findings in those with confirmed short-chain acyl-coA dehydrogenase (SCAD) deficiency range from severe (dysmorphic facial features, feeding difficulties/failure to thrive, metabolic acidosis, ketotic hypoglycemia, lethargy, developmental delay, seizures, hypotonia, dystonia, and myopathy) to normal.
The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load.
Hansen et al., Copenhagen, Denmark. In Bmc Med Genet, 2010
In glucose-tolerant individuals the minor C-allele of rs2014355 of ACADS was associated with reduced measures of glucose-stimulated insulin release during an oral glucose tolerance test.
Brown adipose tissue function in short-chain acyl-CoA dehydrogenase deficient mice.
Goetzman et al., Pittsburgh, United States. In Biochem Biophys Res Commun, 2010
These results suggest that reduced brown adipose tissue function is not the major factor causing cold sensitivity in acyl-CoA dehydrogenase knockout strains.
Molecular pathogenesis of a novel mutation, G108D, in short-chain acyl-CoA dehydrogenase identified in subjects with short-chain acyl-CoA dehydrogenase deficiency.
Kobayashi et al., Hiroshima, Japan. In Hum Genet, 2010
Molecular pathogenesis of a novel mutation, G108D, in ACADS identified in subjects with ACADS deficiency.
A genome-wide perspective of genetic variation in human metabolism.
Suhre et al., München, Germany. In Nat Genet, 2010
For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or solute carriers whose functions match the associating metabolic traits.
Clinical, biochemical, and genetic heterogeneity in short-chain acyl-coenzyme A dehydrogenase deficiency.
Wijburg et al., Amsterdam, Netherlands. In Jama, 2006
SCADD was defined by the presence of (1) increased butyrylcarnitine (C4-C) levels in plasma and/or increased ethylmalonic acid (EMA) levels in urine under nonstressed conditions on at least 2 occasions, in combination with (2) a mutation and/or the c.511C>T or c.625G>A susceptibility variants on each SCAD-encoding (ACADS) allele.
Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep.
Franken et al., Genève, Switzerland. In Nat Genet, 2003
Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only.
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