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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

SATB homeobox 2

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: CAN, Runx2, V1a, SATB1, Tbr1
Papers using SATB2 antibodies
Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms.
Okazawa Hitoshi, In PLoS ONE, 1991
... (1∶500, DAKO, Carpinteria, CA), rabbit anti-Synapsin I (1∶500, Millipore), mouse anti-Cux1 (1∶100, Abnova, Taipei, Taiwan), rabbit anti-Satb2 (1∶1000, Abcam, Cambridge, UK), rat anti-Ctip2 ...
Papers on SATB2
miR-33a-5p modulates TNF-α-inhibited osteogenic differentiation by targeting SATB2 expression in hBMSCs.
Huang et al., Shanghai, China. In Febs Lett, Feb 2016
Luciferase reporter assays and western blotting demonstrated that special AT-rich sequence-binding protein 2 (SATB2) is a target of miR-33a-5p.
SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells.
Costa et al., New York City, United States. In Toxicol Appl Pharmacol, Feb 2016
UNASSIGNED: The special AT-rich sequence-binding protein 2 (SATB2) is a protein that binds to the nuclear matrix attachment region of the cell and regulates gene expression by altering chromatin structure.
SATB2 is localized to the centrosome and spindle maintenance and its knockdown leads to downregulation of CDK2.
Kim et al., Seoul, South Korea. In In Vitro Cell Dev Biol Anim, Jan 2016
UNASSIGNED: Though special AT-rich sequence-binding protein 2 (SATB2) is reported as a transcriptional regulator of skeletal development and osteogenic differentiation, the underlying mechanism of SATB2 is not fully understood.
Developmental mechanisms underlying variation in craniofacial disease and evolution.
Fish, Lowell, United States. In Dev Biol, Jan 2016
Several models outlining developmental mechanisms underlying mutational increases in phenotypic variance are discussed using Satb2-mediated variation in jaw size as an example.
SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer.
Senga et al., Nagoya, Japan. In Oncotarget, Jan 2016
SATB2 acts as a tumor suppressor in laryngeal squamous cell carcinoma and colon cancer, whereas SATB1 promotes the progression of numerous types of cancers.
Young investigator challenge: Cadherin-17 and SATB2 in cytology specimens: Do these new immunostains help in differentiating metastatic colorectal adenocarcinoma from adenocarcinomas of other origins?
Bhuiya et al., New York City, United States. In Cancer Cytopathol, Dec 2015
BACKGROUND: Cadherin-17 (intestinal peptide-associated transporter) and SATB2 (SATB homeobox 2) immunoexpression has recently been described in surgical pathology to have value in establishing the colorectal origin of metastatic adenocarcinoma.
[Diagnostic value of SATB2, CK7 and CK20 in colorectal cancer].
Zhou et al., Nanjing, China. In Zhonghua Bing Li Xue Za Zhi, Aug 2015
OBJECTIVE: To study the diagnostic value of SATB2, together with CK7 and CK20, in colorectal cancer.
Metastatic carcinoma of unknown primary: diagnostic approach using immunohistochemistry.
Hornick et al., Boston, United States. In Adv Anat Pathol, May 2015
This review discusses the approach to the diagnosis of CUP using immunohistochemistry and outlines some of the most useful markers with a particular focus on the utility of lineage-restricted transcription factors, including CDX2, NKX3-1, PAX8, SATB2, TTF-1, and SF1.
SATB1 and 2 in colorectal cancer.
Costa et al., New York City, United States. In Carcinogenesis, Feb 2015
Expression of the SATB2 gene is tissue-specific, and the only epithelial cells expressing SATB2 are the glandular cells of the lower gastrointestinal tract where its expression is regulated by microRNA-31 (miR-31) and miR-182.
The role of SATB2 in skeletogenesis and human disease.
Zhang et al., Shanghai, China. In Cytokine Growth Factor Rev, 2014
Since the discovery of SATB2 (special AT-rich sequence binding protein 2) a decade ago, its pivotal roles in development and tissue regeneration have emerged, particularly in craniofacial patterning and development, palate formation, and osteoblast differentiation and maturation.
Transcriptional dysregulation of neocortical circuit assembly in ASD.
Kwan, Ann Arbor, United States. In Int Rev Neurobiol, 2012
Many of these TFs (TBR1, SOX5, FEZF2, and SATB2) have been implicated in ASD.
The AT-rich DNA-binding protein SATB2 promotes expression and physical association of human (G)γ- and (A)γ-globin genes.
Liu et al., Beijing, China. In J Biol Chem, 2012
results establish SATB2 as a novel gamma-globin gene regulator and provide a glimpse of the differential and cooperative roles of SATB family proteins in modulating clustered genes transcription
SATB2 participates in regulation of menadione-induced apoptotic insults to osteoblasts.
Chen et al., Taipei, Taiwan. In J Orthop Res, 2012
SATB2 may play a crucial role in protecting against oxidative stress-induced osteoblast apoptosis.
miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.
Karsenty et al., New York City, United States. In J Cell Biol, 2012
Genetic evidence obtained in the mouse confirmed the importance of SATB2 regulation by miR-34b/c
Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.
Gusella et al., Boston, United States. In Cell, 2012
We sequenced BCAs in patients with autism or related NDDs, revealing disruption of 33 loci in four general categories: (1) genes previously associated with abnormal neurodevelopment (e.g., AUTS2, FOXP1, and CDKL5), (2) single-gene contributors to microdeletion syndromes (MBD5, SATB2, EHMT1, and SNURF-SNRPN), (3) novel risk loci (e.g., CHD8, KIRREL3, and ZNF507), and (4) genes associated with later-onset psychiatric disorders (e.g., TCF4, ZNF804A, PDE10A, GRIN2B, and ANK3).
Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons.
Atanasoski et al., Basel, Switzerland. In Proc Natl Acad Sci U S A, 2012
Satb2 recruits Ski to the Ctip2 locus, and Ski attracts histone deacetylases, thereby enabling the formation of a functional nucleosome remodeling and deacetylase repressor complex.
A mammalian conserved element derived from SINE displays enhancer properties recapitulating Satb2 expression in early-born callosal projection neurons.
Okada et al., Yokohama, Japan. In Plos One, 2010
The transcription factor Satb2 is expressed by cortical neurons extending axons through the corpus callosum and is a determinant of callosal versus subcortical projection.
Epitope mapping of antibodies using bacterial surface display.
Ståhl et al., Stockholm, Sweden. In Nat Methods, 2008
We analyzed the binding sites of both monoclonal and polyclonal antibodies directed to three human protein targets: (i) the human epidermal growth factor receptor 2 (HER2), (ii) ephrin-B3 and (iii) the transcription factor SATB2.
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.
Grosschedl et al., Freiburg, Germany. In Cell, 2006
SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Bone formation: The nuclear matrix reloaded.
Krumlauf et al., Kansas City, United States. In Cell, 2006
In this issue of Cell, Grosschedl and colleagues (Dobreva et al., 2006) report that the nuclear matrix protein Satb2 represses Hoxa2 expression and acts with other regulatory proteins to promote osteoblast differentiation.
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