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SATB homeobox 1

SATB1, special AT-rich sequence binding protein 1
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
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Top mentioned proteins: CAN, Histone, MARS, V1a, HAD
Papers using SATB1 antibodies
Requirement for the thymus in αβ T lymphocyte lineage commitment.
Nusse Roel, In PLoS Biology, 1997
... Antibodies to β-catenin and SATB1 were purchased from BD Biosciences.
Papers on SATB1
SATB1 Plays a Critical Role in Establishment of Immune Tolerance.
Watanabe et al., Tokyo, Japan. In J Immunol, Feb 2016
Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer that is expressed by T cells.
Expression of SATB1, MTI/II and Ki-67 in Mycosis Fungoides.
Dziegiel et al., Wrocław, Poland. In Anticancer Res, Jan 2016
BACKGROUND/AIM: A genome organizer protein, special AT-rich sequence binding protein 1, (SATB1), was recently shown to play an important role in the development and spread of various malignancies.
SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer.
Senga et al., Nagoya, Japan. In Oncotarget, Jan 2016
UNASSIGNED: Special AT-rich sequence-binding protein 1 and 2 (SATB1/2) are nuclear matrix-associated proteins involved in chromatin remodeling and regulation of gene expression.
Downregulation of SATB1 increases the invasiveness of Jurkat cell via activation of the WNT/β-catenin signaling pathway in vitro.
Tan et al., Guangzhou, China. In Tumour Biol, Jan 2016
UNASSIGNED: Special AT-rich sequence-binding protein-1 (SATB1) is critical for genome organizer that reprograms chromatin organization and transcription profiles, and associated with tumor growth and metastasis in several cancer types.
Integration of the Transcription Factor-Regulated and Epigenetic Mechanisms in the Control of Keratinocyte Differentiation.
Botchkarev, Boston, United States. In J Investig Dermatol Symp Proc, Nov 2015
Transcription factor-regulated and epigenetic mechanisms are highly connected, and the p63 transcription factor has an important role in the higher-order chromatin remodeling of the KC-specific gene loci via direct control of the genome organizer Satb1 and ATP-dependent chromatin remodeler Brg1.
SATB1 and 2 in colorectal cancer.
Costa et al., New York City, United States. In Carcinogenesis, Feb 2015
The special AT-rich sequence-binding proteins 1 and 2 (SATB1/2) are nuclear matrix associated proteins that are transcription factors involved in chromatin remodeling and gene regulation.
MicroRNA-495 suppresses human renal cell carcinoma malignancy by targeting SATB1.
Zhang et al., Haikou, China. In Am J Transl Res, 2014
We further validated SATB1 was a direct target of miR-495 in RCC.
Required enhancer-matrin-3 network interactions for a homeodomain transcription program.
Rosenfeld et al., San Diego, United States. In Nature, 2014
Pit1 association with Satb1 (ref.
Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.
Borghesi, Pittsburgh, United States. In J Immunol, 2014
Provocative new studies establish the chromatin organizer special AT-rich binding protein 1 (Satb1) as one such global regulator in LT-HSCs.
FoxP3, Helios, and SATB1: roles and relationships in regulatory T cells.
Witkowski et al., Chicago, United States. In Int Immunopharmacol, 2013
Two of them, Helios and SATB1, are considered to be important in proper Treg development.
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
Kanakura et al., Suita, Japan. In Immunity, 2013
Comparing gene expression profiles for HSCs and early lymphoid progenitors revealed that Satb1, a global chromatin regulator, was markedly induced with lymphoid lineage specification.
Boosting lymphocyte production.
Murre, San Diego, United States. In Immunity, 2013
(2013) show that the chromatin remodeler Satb1 promotes lymphocyte differentiation in both young and aged stem cells.
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment.
Steidl et al., New York City, United States. In Nat Immunol, 2013
Here we identified the transcription factor and chromatin remodeler Satb1 as a critical regulator of HSC fate.
Lessons from Anaplasma phagocytophilum: chromatin remodeling by bacterial effectors.
Dumler et al., Baltimore, United States. In Infect Disord Drug Targets, 2012
MAR-binding proteins, such as SATB1, interact with histone modifying enzymes resulting in altered gene expression.
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Benoist et al., Boston, United States. In Nat Immunol, 2012
Enforced expression of Helios or Xbp1 elicited distinct signatures, but Eos, IRF4, Satb1, Lef1 and GATA-1 elicited exactly the same outcome, acting in synergy with Foxp3 to activate expression of most of the T(reg) cell signature, including key transcription factors, and enhancing occupancy by Foxp3 at its genomic targets.
MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation.
Candi et al., Roma, Italy. In Biochem Biophys Res Commun, 2012
miR-191 overexpression is sufficient to induce senescence in HEKn cells and that the direct targets, involved in this process, are the Special AT-rich Binding protein 1 (SATB1) and the Cyclin Dependent Kinase 6 (CDK6) mRNAs.
Correlation of SATB1 overexpression with the progression of human rectal cancer.
Sun et al., Chengdu, China. In Int J Colorectal Dis, 2012
SATB1 may play an important role in the progression of human rectal cancer.
Satb1 ablation alters temporal expression of immediate early genes and reduces dendritic spine density during postnatal brain development.
Kohwi et al., Berkeley, United States. In Mol Cell Biol, 2012
In the cerebral cortex, Satb1 binds to genomic loci of multiple immediate early genes (IEGs) (Fos, Fosb, Egr1, Egr2, Arc, and Bdnf) and other key neuronal genes, many of which have been implicated in synaptic plasticity.
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.
Botchkarev et al., Bradford, United Kingdom. In J Cell Biol, 2011
These data provide a novel mechanism by which Satb1, a direct downstream target of p63, contributes in epidermal morphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal progenitor cells.
Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray.
Wang et al., Changsha, China. In Chin Med J (engl), 2011
Study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC.
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