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Creatine kinase, mitochondrial 2

sarcomeric mitochondrial creatine kinase, sMtCK, CKMT2
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ubiquitous mitochondrial creatine kinase, muscle creatine kinase, CAN, fibrillin-1, FasT
Papers on sarcomeric mitochondrial creatine kinase
Hearts of some Antarctic fishes lack mitochondrial creatine kinase.
Ortego et al., Fairbanks, United States. In Comp Biochem Physiol A Mol Integr Physiol, 2014
Mammalian oxidative muscle couples expression of sMtCK with M-CK, creating an energy shuttle between mitochondria and myofibrils.
Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury.
Murphy et al., Bristol, United Kingdom. In Bmc Genomics, 2013
Upregulated genes included Factor V, SLC16A3 and CKMT2 whereas downregulated genes included GST, CPE, MMP7 and SELL.
Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation.
Noma et al., Tokushima, Japan. In Plos One, 2013
Three additional adenine nucleotide metabolizing enzymes, including mitochondrial creatine kinases (CKMT1 and CKMT2) and nucleoside diphosphate kinase isoform D (NDPK-D), have been found in IMS.
Tissue specific phosphorylation of mitochondrial proteins isolated from rat liver, heart muscle, and skeletal muscle.
Højlund et al., Odense, Denmark. In J Proteome Res, 2013
Multiple tissue-specific phosphorylation sites were identified in tissue-specific enzymes such as those encoded by HMGCS2, BDH1, PCK2, CPS1, and OTC in liver mitochondria, and CKMT2 and CPT1B in heart and skeletal muscle.
Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation.
Russell et al., Australia. In Am J Physiol Cell Physiol, 2013
STARS overexpression increased Pgc-1α, Srf, Ckmt2, Cpt-1β, and Mhc1 mRNA.
Inferring the in vivo cellular program of developing bovine skeletal muscle from expression data.
Dalrymple et al., Australia. In Gene Expr Patterns, 2013
Enriched among the most variably expressed genes from the entire data set were molecules regulating mitochondrial metabolism of carbohydrate (PDK4), fat (UCP3), protein (AGXT2L1) and high energy phosphate (CKMT2).
Expression and localization of creatine kinase in the preimplantation embryo.
Leese et al., York, United Kingdom. In Mol Reprod Dev, 2013
Using quantitative PCR, transcripts of four subunit isoforms of CK--CKM, CKB, CKMT1, and CKMT2--were detectable at all developmental stages, from the presumptive zygote to late blastocyst, but there was no obvious pattern in gene expression.
Genes that characterize T3-predominant Graves' thyroid tissues.
Takano et al., Suita, Japan. In Eur J Endocrinol, 2013
Among these, seven genes, leucine-rich repeat neuronal 1 (LRRN1), bone morphogenetic protein 8a (BMP8A), N-cadherin (CDH2), phosphodiesterase 1A (PDE1A), creatine kinase mitochondrial 2 (CKMT2), integrin beta-3 (ITGB3), and protein tyrosine phosphatase non-receptor type 4 (PTPN4), were confirmed to be differentially expressed in DIO1 or DIO2 over- and underexpressing Graves' tissues.
Regulation of sodium-calcium exchanger activity by creatine kinase.
Kao et al., Taipei, Taiwan. In Adv Exp Med Biol, 2012
We used the yeast two-hybrid method to screen a human heart cDNA library and found that the C-terminal region of sarcomeric mitochondrial creatine kinase (sMiCK) interacted with NCX1IL.
Acyl chain composition determines cardiolipin clustering induced by mitochondrial creatine kinase binding to monolayers.
Granjon et al., Villeurbanne, France. In Biochim Biophys Acta, 2011
Data show that mtCK-cardiolipin domains were observed not only with unsaturated cardiolipins, but also with the cardiolipin precursor phosphatidylglycerol.
Regulation of sodium-calcium exchanger activity by creatine kinase under energy-compromised conditions.
Kao et al., Taipei, Taiwan. In J Biol Chem, 2010
To search for the molecules that interact with NCX1IL and regulate NCX1 activity, we used the yeast two-hybrid method to screen a human heart cDNA library and found that the C-terminal region of sarcomeric mitochondrial creatine kinase (sMiCK) interacted with NCX1IL.
Quadruplex structures of muscle gene promoter sequences enhance in vivo MyoD-dependent gene expression.
Fry et al., Haifa, Israel. In Nucleic Acids Res, 2010
HEK293 cells were transfected with FL expressing p4RTK-FL vector alone or together with MyoD expressing pEMSV-MyoD plasmid, with quadruplexes of alpha7 integrin or sarcomeric mitochondrial creatine kinase (sMtCK) muscle gene promoters or with a combination thereof.
Development and performance of an enzyme immunoassay to detect creatine kinase isoenzyme MB activity using anti-mitochondrial creatine kinase monoclonal antibodies.
Kumasaka et al., Tokyo, Japan. In Scand J Clin Lab Invest, 2008
RESULTS: The two types of monoclonal antibodies developed by us were isoenzyme-specific to sMtCK or uMtCK.
Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma.
Ray et al., Calcutta, India. In Febs J, 2008
In mice, immunoblotting with antibodies against cytosolic muscle-type creatine kinase and sarcomeric mitochondrial creatine kinase showed that both of these isoforms decreased as malignancy progressed.
Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes.
Seppet et al., Tartu, Estonia. In Biochim Biophys Acta, 2008
In both types of HL-1 cells, the AK2, CKB, HK1 and HK2 genes were expressed at higher levels than the CKM, CKMT2 and AK1 genes.
Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
Min et al., Seoul, South Korea. In Clin Cancer Res, 2007
CK2alpha has a role in progression of acute myeloid leukemia
Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle.
Pison et al., Grenoble, France. In Am J Physiol Regul Integr Comp Physiol, 2005
After the training period, intracellular energetic units had a higher control of mitochondrial respiration by creatine linked to a more efficient functional coupling adenine nucleotide translocase-mitochondrial creatine kinase.
C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase.
Wallimann et al., Zürich, Switzerland. In J Biol Chem, 2004
three C-terminal lysines determine high affinity sMtCK/cardiolipin interaction and its effects on MtCK structure, whereas low level binding and some effect on membrane fluidity depend on other structural components
Expression of the mitochondrial creatine kinase genes.
Strauss et al., Saint Louis, United States. In Mol Cell Biochem, 1994
In rats and humans, sarcomere-specific MtCK (sMtCK) is expressed only in skeletal and heart muscle, and has 87% nucleotide identity across the 1257 bp coding region.
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