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Discs, large homolog 1

SAP97, hDlg, Dlg1, synapse-associated protein 97
This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known. [provided by RefSeq, Feb 2011] (from NCBI)
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Top mentioned proteins: PSD-95, CAN, V1a, ACID, GluR1
Papers using SAP97 antibodies
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures
Du Quansheng et al., In The Journal of Cell Biology, 2002
... The following antibodies were also used: mouse anti–α-tubulin (Sigma-Aldrich), mouse anti–ZO-1(Invitrogen), mouse anti–β-catenin (BD), mouse anti-Dlg1 (Santa Cruz Biotechnology, Inc.), rabbit anti-aPKC (Santa ...
Centrosome reorientation in wound-edge cells is cell type specific
Etienne-Manneville Sandrine et al., In The Journal of Cell Biology, 2001
... from Transduction Laboratories; anti-Dlg1 polyclonal from Thermo Fisher Scientific; monoclonal anti-Dlg1 and anti-DHC from Santa Cruz Biotechnology, Inc.; anti-pericentrin and anti-DIC ...
Cdc42 and Par6–PKCζ regulate the spatially localized association of Dlg1 and APC to control cell polarization
Hall Alan et al., In The Journal of Cell Biology, 1995
... from the following companies: anti–α-tubulin from Sigma-Aldrich; phalloidin-rhodamine from Molecular Probes; anti-EB1 from Transduction Labs; anti-Dlg1 from Santa Cruz Biotechnology, Inc ...
Discs large (Dlg1) complexes in lymphocyte activation
Seed Brian et al., In The Journal of Cell Biology, 1994
... obtained include: Cbl, PKC-θ, CD45 (Transduction Laboratories); actin (ICN Biomedicals); chapsyn (Calbiochem); CD3ζ (BD Biosciences); Dlg1, TCRζ (Santa Cruz Biotechnology, Inc.); GADS, Lck, Zap-70, ...
Papers on SAP97
Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia.
UK10K Consortium et al., London, United Kingdom. In Ann Hum Genet, Jan 2016
Disc Large 1 expression is altered by Human Papillomavirus E6/E7 proteins in organotypic cultures of human keratinocytes.
Gardiol et al., São Paulo, Brazil. In J Gen Virol, Jan 2016
Among polarity proteins, we focused on human Disc Large (DLG1), which is localized mainly at adherens junctions and contributes to the control of cell proliferation.
Targeted Gene Resequencing (Astrochip) to Explore the Tripartite Synapse in Autism-Epilepsy Phenotype with Macrocephaly.
Santorelli et al., Pisa, Italy. In Neuromolecular Med, Dec 2015
We detected rare or previously unknown predicted deleterious missense changes in GJA1, SLC12A2, SNTA1, EFNA3, CNTNAP2, EPHA4, and STXBP1 in seven patients and two high-frequency variants in DLG1 in six individuals.
HPV16 E6 Controls the Gap Junction Protein Cx43 in Cervical Tumour Cells.
Graham et al., Chicago, United States. In Viruses, Oct 2015
HPV E6 oncoprotein binds the cell polarity regulator hDlg (human homologue of Drosophila Discs Large).
[The role of calcium/calmodulin dependent serine protein kinase in embryonic development and related diseases].
Yuan et al., Nanjing, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Jun 2015
It also can influence renal development through interaction with DLG1.
Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia.
Nishikawa et al., Tokyo, Japan. In Transl Psychiatry, 2014
The human discs, large homolog 1 gene (DLG1) is mapped to the schizophrenia-susceptibility locus 3q29, and it encodes a scaffold protein that interacts with the N-methyl-D-aspartate receptor presumably dysregulated in schizophrenia.
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
Deussing et al., München, Germany. In Plos One, 2014
We identified several members of the membrane-associated guanylate kinase (MAGUK) family: postsynaptic density protein 95 (PSD95), synapse-associated protein 97 (SAP97), SAP102 and membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2).
MAS C-Terminal Tail Interacting Proteins Identified by Mass Spectrometry- Based Proteomic Approach.
Karnik et al., Cleveland, United States. In Plos One, 2014
A 'cardiac-specific finger print' of MAS interacting PDZ proteins was identified which includes DLG1, MAGI1 and SNTA.
Label-free mass spectrometric analysis reveals complex changes in the brain proteome from the mdx-4cv mouse model of Duchenne muscular dystrophy.
Ohlendieck et al., Ireland. In Clin Proteomics, 2014
Interesting brain tissue-associated proteins with an increased concentration in the mdx-4cv animal model were represented by the glial fibrillary acidic protein GFAP, the neuronal Ca(2+)-binding protein calretinin, annexin AnxA5, vimentin, the neuron-specific enzyme ubiquitin carboxyl-terminal hydrolase isozyme L1, the dendritic spine protein drebrin, the cytomatrix protein bassoon of the nerve terminal active zone, and the synapse-associated protein SAP97.
The anchoring protein SAP97 influences the trafficking and localisation of multiple membrane channels.
Montgomery et al., Auckland, New Zealand. In Biochim Biophys Acta, 2014
SAP97 is a member of the MAGUK family of proteins that play a major role in the trafficking and targeting of membrane ion channels and cytosolic structural proteins in multiple cell types.
DLG5 in cell polarity maintenance and cancer development.
Liu et al., Xi'an, China. In Int J Biol Sci, 2013
DLG5 has evolved in the same manner as DLG1 and ZO1, two well-studied MAGUKs proteins.
ADAM10 in synaptic physiology and pathology.
Di Luca et al., Milano, Italy. In Neurodegener Dis, 2013
Furthermore, ADAM10 interaction with synapse-associated protein 97 (SAP97) is necessary for LTD-induced ADAM10 trafficking and required for LTD maintenance and LTD-induced spine morphology changes.
GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord.
Kalb et al., Philadelphia, United States. In Ann N Y Acad Sci, 2013
This review focuses on the mechanism by which the GluA1 subunit of AMPA-R transforms synaptic activity into dendrite growth, and describes the essential role of the GluA1 binding partner SAP97 (synapse-associated protein of 97 kDa molecular weight) in this process.
A functional interaction between the MAGUK protein hDlg and the gap junction protein connexin 43 in cervical tumour cells.
Graham et al., Glasgow, United Kingdom. In Biochem J, 2012
Dlg is a physiologically relevant regulator of Cx43 in transformed epithelial cells.
Characterization of the structure and intermolecular interactions between the connexin 32 carboxyl-terminal domain and the protein partners synapse-associated protein 97 and calmodulin.
Sorgen et al., Omaha, United States. In J Biol Chem, 2012
Cx32 is differentially phosphorylated and exists in a complex with SAP97 and CaM.
A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.
Pulido et al., Valencia, Spain. In J Cell Biochem, 2012
Data suggest that hDlg may serve as a platform to bring in proximity APC and PTEN tumor suppressor activities.
Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.
Conforti et al., Cincinnati, United States. In Am J Physiol Cell Physiol, 2012
Knockdown of Dlg1, which binds Kv1.3 channels to tyrosine kinase Lck, abolishes modulation of Kv1.3 channels.
The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.
Banks et al., Trieste, Italy. In Plos Pathog, 2012
Dlg1 has a distinct oncogenic function in the context of HPV induced malignancy, one of the outcomes of which is increased RhoG activity and increased invasive capacity.
Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells.
Doe et al., Eugene, United States. In Cell, 2009
We identify a previously unrecognized evolutionarily conserved Pins domain (Pins(LINKER)) that requires Aurora-A phosphorylation to recruit Discs large (Dlg; PSD-95/hDlg in mammals) and promote partial spindle orientation.
Discs-Large and Strabismus are functionally linked to plasma membrane formation.
Cho et al., Houston, United States. In Nat Cell Biol, 2003
In addition, ectopic co-expression of Stbm (which associated with post-Golgi vesicles) and the mammalian Dlg homologue SAP97/hDlg promoted translocation of SAP97 from the cytoplasm to both post-Golgi vesicles and the plasma membrane.
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