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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sin3A-associated protein, 30kDa

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: mSin3A, Histone, V1a, CYP3A4, HDAC
Papers on SAP30
Redox-dependent disulfide bond formation in SAP30L corepressor protein: Implications for structure and function.
Jänis et al., Joensuu, Finland. In Protein Sci, Dec 2015
SAP30L, together with a highly homologous SAP30 as well as other SAP proteins (i.e., SAP25, SAP45, SAP130 and SAP180), is an essential component of the Sin3A corepressor complex, although its actual role has remained elusive.
Characterizing the effect of Bortezomib on Rift Valley Fever Virus multiplication.
Narayanan et al., Manassas, United States. In Antiviral Res, Aug 2015
In silico ubiquitination prediction analysis predicted that known NSs interactors (SAP30, YY1, and mSin3A) have multiple putative ubiquitination sites, while NSs itself was not predicted to be ubiquitinated.
Antioxidant and antitumor activities in vitro of polysaccharides from E. sipunculoides.
Sun et al., Hangzhou, China. In Int J Biol Macromol, 2014
Three polysaccharides (SAP30, SAP60 and SAP80) were separated from the body of Edwardsia sipunculoides by tissue homogenate and papain hydrolysis.
Identification of genes differentially expressed in myogenin knock-down bovine muscle satellite cells during differentiation through RNA sequencing analysis.
Choi et al., Kyŏngsan, South Korea. In Plos One, 2013
Computational analysis of the differentially expressed genes has identified the significance of genes such as SAP30-like (SAP30L), Protein lyl-1 (LYL1), various matrix metalloproteinases, and several glycogenes in myogenesis.
SAP30L (Sin3A-associated protein 30-like) is involved in regulation of cardiac development and hematopoiesis in zebrafish embryos.
Lohi et al., Tampere, Finland. In J Cell Biochem, 2012
The Sin3A-associated proteins SAP30 and SAP30L share 70% sequence identity and are part of the multiprotein Sin3A corepressor complex.
Endothelial cells present an innate resistance to glucocorticoid treatment: implications for therapy of primary vasculitis.
Viemann et al., Münster, Germany. In Ann Rheum Dis, 2012
Insufficient induction of SAP30, an important constituent of the Sin3A-histone deacetylase complex, in EC suggests impairment of transrepression due to co-repressor absence.
Functional analysis of Rift Valley fever virus NSs encoding a partial truncation.
Ikegami et al., Galveston, United States. In Plos One, 2011
NSs self-associates at the C-terminus 17 aa., while NSs at aa.210-230 binds to Sin3A-associated protein (SAP30) to inhibit the activation of IFN-β promoter.
Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding.
Radhakrishnan et al., Evanston, United States. In J Biol Chem, 2011
show using NMR that the mSin3A PAH3-SAP30 SID complex can bind to nucleic acids, hinting at a role for a nucleolar localization sequence in the SID alphaA helix in targeting the Rpd3L/Sin3L complex for silencing ribosomal RNA genes
Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.
Sarcevic et al., Melbourne, Australia. In J Biol Chem, 2011
RBP1 binds to the pocket region of pRb via an LXCXE motif and to the SAP30 subunit of the mSin3·HDAC complex and, thus, acts as a bridging protein in this multisubunit complex.
Transcriptional regulation by HSV-1 induced HTRP via acetylation system.
Li et al., Kunming, China. In Virol Sin, 2010
HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the deacetylation transfer enzyme HDAC.
Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid.
Sá-Correia et al., Lisbon, Portugal. In Omics, 2010
Among these genes, the expression of SAP30 and HRK1 provided the strongest protective effect toward acetic acid.
SLy2 targets the nuclear SAP30/HDAC1 complex.
Beer-Hammer et al., Düsseldorf, Germany. In Int J Biochem Cell Biol, 2010
In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1.
Nonstructural NSs protein of rift valley fever virus interacts with pericentromeric DNA sequences of the host cell, inducing chromosome cohesion and segregation defects.
Bonnefoy et al., Paris, France. In J Virol, 2010
Role in the establishment of NS interactions with host DNA sequences and Rift Valley fever virus (RVFV) pathogenesis.
DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides.
Lohi et al., Tampere, Finland. In Mol Cell Biol, 2009
findings demonstrate new functions for SAP30L and SAP30 by showing that they can associate directly with core histones as well as naked DNA
Phylogenetic analysis of the SAP30 family of transcriptional regulators reveals functional divergence in the domain that binds the nuclear matrix.
Lohi et al., Tampere, Finland. In Bmc Evol Biol, 2008
In this report we examine the evolution of two proteins in this complex, the Sin3-associated proteins SAP30L and SAP30, by using an archive of protein sequences from 62 species.
Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.
Steger et al., Köln, Germany. In Arch Biochem Biophys, 2007
PBF binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.
Reinberg et al., United States. In Cell, 1997
In addition, two novel mSin3-associated polypeptides, SAP18 and SAP30, were identified.
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