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Amyloid P component, serum

SAP, Serum Amyloid P-Component
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, C-reactive protein
Papers using SAP antibodies
Flow cytometric platform for high-throughput single nucleotide polymorphism analysis.
Lee Edmund Jon Deoon et al., In Biological Procedures Online, 2000
... Shrimp Alkaline Phosphatase (SAP) was obtained from Promega, Madison, USA and Exonuclease I from New England Biolabs, Beverly, MA, USA ...
Papers on SAP
SLAM family receptors in normal immunity and immune pathologies.
Veillette et al., Montréal, Canada. In Curr Opin Immunol, Feb 2016
By way of their cytoplasmic domain, SLAM-related receptors associate with the SLAM-associated protein (SAP) family of adaptors, which control the signals and functions of SLAM family receptors.
MCG101-induced cancer anorexia-cachexia features altered expression of hypothalamic Nucb2 and Cartpt and increased plasma levels of cocaine- and amphetamine-regulated transcript peptides.
Smedh et al., Göteborg, Sweden. In Oncol Rep, Feb 2016
In addition, we examined changes in plasma TSH, CART peptides (CARTp) and serum amyloid P component (SAP).
Purification and Structural Analysis of LEM-Domain Proteins.
Zinn-Justin et al., Paris, France. In Methods Enzymol, Dec 2015
The LEM domain adopts an α-helical fold also found in SAP and HeH domains of prokaryotes and unicellular eukaryotes.
[Effect of Qingyi Granule on HMGB1 Expression in Liver and Renal Tissues of Severe Acute Pancreatitis Rats].
Wang et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
OBJECTIVE: To explore the effect of Qingyi Granule (QYG) on high mobility group box-1 (HMGB1) expressions in liver and renal tissues of severe acute pancreatitis (SAP) rats.
[Effect of Tanshinone II A on Cytokines of Rats with Severe Acute Pancreatitis Lung Injury].
Shen et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
OBJECTIVE: To explore the effect of Tanshinone II A on severe acute pancreatitis (SAP) lung injury (ALI) rats and its possible mechanism.
Central role of neutrophil in the pathogenesis of severe acute pancreatitis.
Xu et al., Shanghai, China. In J Cell Mol Med, Nov 2015
Severe acute pancreatitis (SAP) is an acute abdominal disease with the strong systemic inflammatory response, and rapidly progresses from a local pancreatic damage into multiple organ dysfunction.
Therapeutic blockade of interleukin-6 by tocilizumab in the management of AA amyloidosis and chronic inflammatory disorders: a case series and review of the literature.
Lachmann et al., London, United Kingdom. In Clin Exp Rheumatol, Nov 2015
METHODS: In addition to routine haematology and biochemistry (including SAA) blood panels, patients with AA amyloidosis underwent SAP scintigraphy to quantify amyloid load.
Serum amyloid P (SAP) is associated with impaired brachial artery flow-mediated dilation in chronically HIV-1 infected adults on stable antiretroviral therapy.
Chow et al., Honolulu, United States. In Hiv Clin Trials, Nov 2015
Of all biomarkers tested, higher level of C-reactive protein (CRP) (beta =  - 0.695, P = 0.030) and serum amyloid P (SAP) (beta =  - 1.318, P = 0.021) were significantly associated with lower brachial artery FMD in univariable regression analysis.
Continuous Regional Arterial Infusion of Protease Inhibitors for Treatment of Severe Acute Pancreatitis: Systematic Review and Meta-Analysis.
Sanui et al., Saitama, Japan. In Pancreas, Oct 2015
OBJECTIVE: We performed a systematic review and meta-analysis of observational studies and randomized controlled trials (RCTs) to assess the benefit and risk of continuous regional arterial infusion (CRAI) of protease inhibitors (CRAIpis) in patients with severe acute pancreatitis (SAP) or acute necrotizing pancreatitis (ANP).
Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component.
Pepys et al., London, United Kingdom. In N Engl J Med, Oct 2015
BACKGROUND: The amyloid fibril deposits that cause systemic amyloidosis always contain the nonfibrillar normal plasma protein, serum amyloid P component (SAP).
Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group.
Meisel et al., Salford, United Kingdom. In Stroke, Aug 2015
RESULTS: Consensus was reached for the following: (1) stroke-associated pneumonia (SAP) is the recommended terminology for the spectrum of lower respiratory tract infections within the first 7 days after stroke onset; (2) modified Centers for Disease Control and Prevention (CDC) criteria are proposed for SAP as follows-probable SAP: CDC criteria met, but typical chest x-ray changes absent even after repeat or serial chest x-ray; definite SAP: CDC criteria met, including typical chest x-ray changes; (3) there is limited evidence for a diagnostic role of white blood cell count or C-reactive protein in SAP; and (4) there is insufficient evidence for the use of other biomarkers (eg, procalcitonin).
SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.
Terhorst et al., Boston, United States. In Blood, 2012
In the absence of SAP, several routes of natural killer cell-mediated antibody production are still accessible.
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.
Crotty et al., Los Angeles, United States. In Immunity, 2012
Humans and mice deficient in the adaptor protein SAP (Sh2d1a) have a major defect in humoral immunity, resulting from a lack of T cell help for B cells.
SAP signaling: a dual mechanism of action.
Shaw et al., Saint Louis, United States. In Immunity, 2012
(2012) show that the adaptor protein SAP regulates both positive and negative signals through SLAM receptors to stabilize intercellular contacts.
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Veillette et al., Montréal, Canada. In Immunity, 2012
SAP secures NK cell activation in 2 ways. It couples SLAM receptors to Fyn, triggering Vav-1. It coupled SLAM family receptors to the kinase Fyn, which triggered the exchange factor Vav-1 and augmented NK cell activation.
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.
Schwartzberg et al., Bethesda, United States. In Immunity, 2012
SAP(-) cytotoxic lymphocytes had defects in synapse organization with B-cell & low-avidity T-cell targets. SAP & SLAM receptors regulate positive & negative signals for synapse organization & cytotoxicity thresholds for distinct targets.
The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.
Macdonald et al., Edmonton, Canada. In Diabetologia, 2012
Direct interaction between syntaxin 1A and the Kv2.1 C-terminus is required for efficient insulin exocytosis and glucose-stimulated insulin secretion.
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.
Wei et al., Hefei, China. In Plos Pathog, 2011
TGF-beta1 may reduce the expression of NKG2D/DAP10 and 2B4/SAPin patients with hepatitis B.
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