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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Sphingosine-1-phosphate receptor 2

S1P2, Edg-5, H218, AGR16
G protein-coupled receptor for sphingosine 1-phosphate [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: S1P1, S1P3, V1a, Rhodopsin, ACID
Papers on S1P2
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.
Xia et al., Sydney, Australia. In Biochim Biophys Acta, Feb 2016
In contrast, the siRNA-mediated knockdown of SphK1 or S1P receptors, S1P2 and S1P3, profoundly inhibited lipid accumulation in hepatocytes.
Sphingosine-1-Phosphate reduces ischemia/reperfusion injury by phosphorylating the gap junction protein Connexin43.
Kwak et al., Copenhagen, Denmark. In Cardiovasc Res, Feb 2016
Mechanistic in vitro and ex vivo studies revealed that 5 min of S1P treatment induced phosphorylation of the gap junction protein Connexin43 (Cx43) on Serine368, which was mediated by S1P2 and S1P3, but not by S1P1, receptors in cardiomyocytes.
S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.
Wettschureck et al., Frankfurt am Main, Germany. In Arterioscler Thromb Vasc Biol, Jan 2016
OBJECTIVES: Monocyte/macrophage recruitment and activation at vascular predilection sites plays a central role in the pathogenesis of atherosclerosis.
S1P3 receptor influences key physiological properties of fast-twitch extensor digitorum longus muscle.
Danieli-Betto et al., Padova, Italy. In J Appl Physiol, Jan 2016
S1P3 deficiency enhanced the expression level of S1P1 and S1P2 receptors mRNA in S1P3-null EDL muscle.
Upregulation of S1P1 and Rac1 receptors in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
Puri et al., Dublin, Ireland. In Pediatr Surg Int, Dec 2015
S1P regulates cell proliferation and angiogenesis via different receptors, S1P1, S1P2 and S1P3, which all influence the expression of Ras-related C3 botulinum toxin substrate 1 (Rac1).
Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes.
Park et al., Chŏnju, South Korea. In Mol Med Report, Nov 2015
In particular, the S1P2 receptor has distinct roles in the S1P‑mediated differentiation of certain cell types.
Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.
Seko et al., Ōsaka, Japan. In Bioorg Med Chem Lett, Nov 2015
We subsequently designed and synthesized a hybrid compound of 5 and the 1,3-bis(aryloxy) benzene derivative 1, which was previously reported by our group to be an S1P2 antagonist.
Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination.
Lane et al., Salt Lake City, United States. In Am J Pathol, Oct 2015
Cultured NPCs expressed transcripts for S1P receptors S1P1, S1P2, S1P3, S1P4, and S1P5.
Signal transduction by HDL: agonists, receptors, and signaling cascades.
Nofer, Münster, Germany. In Handb Exp Pharmacol, 2014
Several HDL-associated receptor ligands such as apolipoprotein A-I (apoA-I) or sphingosine-1-phosphate (S1P) have been identified in addition to HDL holoparticles, which interact with surface receptors such as ATP-binding cassette transporter A1 (ABCA1); S1P receptor types 1, 2, and 3 (S1P1, S1P2, and S1P3); or scavenger receptor type I (SR-BI) and activate intracellular signaling cascades encompassing kinases, phospholipases, trimeric and small G-proteins, and cytoskeletal proteins such as actin or junctional protein such as connexin43.
Sphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Yang et al., Kunming, China. In Int J Clin Exp Med, 2014
The S1P receptors S1P1 and S1P3 promote, while S1P2 inhibits VSMC proliferation and migration in vitro in response to S1P.
Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts.
Bourgoin et al., Moncton, Canada. In Mediators Inflamm, 2014
Furthermore, incubation with the S1P2 and S1P3 receptor antagonists, JTE-013 and CAY10444, reduced CoCl2-mediated chemokine production in normal FLS but not in RAFLS.
Sphingolipids in acute lung injury.
Yang et al., Aachen, Germany. In Handb Exp Pharmacol, 2012
Sphingolipids are critically involved in the disease process that they can both expedite and extenuate: They expedite inflammation by promoting chemotaxis (neutral sphingomyelinase), increased endothelial permeability (acid sphingomyelinase, S1P3-receptors), increased epithelial permeability (S1P2- and S1P3-receptors), and delaying neutrophil apoptosis (neutral sphingomyelinase, S1P1-receptors).
S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.
Huang et al., Guangzhou, China. In Exp Cell Res, 2012
S1P2 receptor was significantly up-regulated under diabetic condition. S1P2 receptor mediated fibronectin expression through the activation of S1P-S1P2-MAPK axis in mesangial cells under high glucose condition.
Senescent endothelial dysfunction is attributed to the up-regulation of sphingosine-1-phosphate receptor-2 in aged rats.
Zhou et al., Changsha, China. In Mol Cell Biochem, 2012
Results indicate that the impaired functions (such as chemotactic, wound healing, and morphogenetic responses) in senescent endothelial cells are mediated by the S1P(2) receptor.
LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells.
Huang et al., Guangzhou, China. In Pathol Res Pract, 2012
Inflammatory mediators lipopolysaccharide and TNF-alpha induce S1PR2 expression in endothelium, suggesting that S1PR2 up-regulation may be involved in LPS and TNF-alpha elicited endothelial barrier dysfunction.
Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides.
Di Nardo et al., San Diego, United States. In J Immunol, 2012
Skin mast cells protect mice against vaccinia virus by triggering mast cell receptor S1PR2 and releasing antimicrobial peptides.
Differential expression of sphingosine-1-phosphate receptors in abdominal aortic aneurysms.
Cheng et al., Hong Kong, Hong Kong. In Mediators Inflamm, 2011
abdominal aortic aneurysms have down-regulation of the S1P2 protein with simultaneous up-regulation of the S1P3 protein, but not S1P1
Probe Development Efforts for an Allosteric Agonist of the Sphingosine 1-phosphate Receptor 3 (S1P3)
Rosen et al., Bethesda, United States. In Unknown Journal, 2011
ML249 activates S1P3 receptor with an EC50 of 72.3 nM–132 nM, and is inactive as an agonist against other members of the receptor family S1P1 (EC50 >10 μM), S1P2 (EC50 >50 μM), S1P4 (EC50 >50 μM), and S1P5 (EC50 >25 μM).
Lysophospholipid receptors.
Chun et al., San Diego, United States. In Annu Rev Pharmacol Toxicol, 2000
gpcr26, H218, AGR16, nrg-1) as members of a common cognate G protein-coupled receptor family.
Identification of a Novel Agonist of the Sphingosine 1-phosphate Receptor 4 (S1P4)
Roberts et al., Bethesda, United States. In Unknown Journal, 0001
ML248 activates S1P4 receptor with a half maximal effective concentration (EC50) of 37.7 nM–79.1 nM, and is inactive as an agonist against other members of the receptor family, with EC50s > 25 μM against S1P1, S1P2, and S1P3 receptors, and an EC50 of 2.1 μM against the S1P5 receptor.
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