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S100 calcium binding protein B

S-100, Nef, S100B
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, CD4, V1a
Papers using S-100 antibodies
Pseudo-merohedral twinning and noncrystallographic symmetry in orthorhombic crystals of SIVmac239 Nef core domain bound to different-length TCRζ fragments
Stern Lawrence J. et al., In Acta Crystallographica Section D: Biological Crystallography, 2009
... Following cell lysis, the Nef fusion protein was isolated by Ni–NTA affinity chromatography (Qiagen) under denaturing conditions (8  ...
Cell death
Shintaku Masayuki, In Virchows Archiv, 2008
... LC3 (polyclonal; Medical & Biological Laboratories, Nagoya, Japan; 1:1,000), CD68 (clone KP1, Dako; 1:100), and S-100 protein (clone ER-PR8, Dako; 1:500) ...
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma
Delabie Jan et al., In Journal of Hematopathology, 2007
... S-100 (polyclonal)DAKO Cytomation, Denmark A/S ...
Cell adhesion protein expression in melanocytic matricoma
Burchette James L et al., In Rare Tumors, 2006
... IgG1, (Dako) used at 1:100; HMB- 45 mouse monoclonal IgG1 (Dako) used at 1:100, and S-100 rabbit polyclonal antibody (Dako, Carpinteria CA) used at ...
A case of primary small cell carcinoma of the breast
Bergkvist Leif et al., In Pathology Research International, 2006
... clone CALP1, 1 : 600), p63 (Biocare Medical, clone BC4A4, 1 : 100), CD10 (Dako, clone 56C6, 1 : 50), and S-100 protein (Dako, clone ZO311, 1 : 3000) ...
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Papers on S-100
Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases.
Christofi et al., Napoli, Italy. In Inflamm Bowel Dis, Feb 2016
Probiotics, palmitoylethanolamide (peroxisome proliferator-activated receptor-α), interleukin-1 antagonists (anakinra), and interventions acting on nitric oxide, receptor for advanced glycation end products, S100B, or purinergic signaling pathways are relevant clinical targets on EGCs with therapeutic potential.
Pickkers et al., Nijmegen, Netherlands. In Shock, Feb 2016
In the present review, we provide an overview of several well known DAMPs (high-mobility group box 1, heat-shock proteins, s100 proteins, nucleic acids, and hyaluronan) and their effects on the immune system.
Migraine in patients with systemic lupus erythematosus is associated with reduced cerebral grey matter volume but not with measures of glial activation or anti-NR2 or anti-P antibodies.
Omdal et al., Stavanger, Norway. In Eur J Neurol, Feb 2016
Anti-NR2 and anti-P antibodies and protein S100B were measured in cerebrospinal fluid.
Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages.
Suzu et al., Kumamoto, Japan. In J Immunol, Feb 2016
In this study, we show that HIV-1 promotes TNT formation per se via its protein Nef and a cellular protein M-Sec, which appears to mediate approximately half of viral spread among monocyte-derived macrophages (MDMs).
Vaccine Induction of Lymph Node-Resident Simian Immunodeficiency Virus Env-Specific T Follicular Helper Cells in Rhesus Macaques.
Robert-Guroff et al., Bethesda, United States. In J Immunol, Feb 2016
Macaques were primed twice mucosally with adenovirus 5 host range mutant recombinants encoding SIV Env, Rev, Gag, and Nef followed by two i.m. boosts with monomeric SIV gp120 or oligomeric SIV gp140 proteins.
Modulation of apoptosis and viral latency- an axis to be well understood for successful cure of HIV.
Gaur et al., In J Gen Virol, Feb 2016
HIV-1encoded proteins such as the envelope gp120 (glycoprotein gp120), Tat (trans-activator of transcription), Nef (negative regulatory factor), Vpr (viral protein R), Vpu (viral protein unique) and protease are known to be effective in modulating host cell signaling pathways that lead to an alteration in apoptosis of both HIV-infected and uninfected bystander cells.
Intracerebroventricular application of S100B selectively impairs pial arteriolar dilating function in rats.
Pelligrino et al., Chicago, United States. In Brain Res, Feb 2016
UNASSIGNED: S100B is an astrocyte-derived protein that can act through the receptor for advanced glycation endproducts (RAGE) to mediate either "trophic" or "toxic" responses.
Biomarkers in Silent Traumatic Brain Injury.
Kadoglou et al., London, United Kingdom. In Curr Pharm Des, Jan 2016
In this review of the literature, we present novel circulating biomolecules, as potential biomarkers of silent TBI, like neurofilaments, Cleaved-Tau (C-Tau), Microtubule-Associated Protein 2 (MAP2), Neuron-Specific Enolase, S100B and ferritin.
Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
Ueno et al., Kumamoto, Japan. In Mbio, Dec 2015
UNLABELLED: HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells.
Brain injury biomarkers in the setting of cardiac surgery: Still a world to explore.
Egea-Guerrero et al., Sevilla, Spain. In Brain Inj, Dec 2015
RESULTS: The biomarkers that appear to be better indicators of brain injury severity in cardiac surgery and its consequences are S100B protein, neuron-specific enolase, glial fibrillary acidic protein, tau protein, matrix metalloproteinase-9, ubiquitin C terminal hydroxylase-L1 and neurofilaments.
HIV-1 Nef hijacks clathrin coats by stabilizing AP-1:Arf1 polygons.
Hurley et al., Berkeley, United States. In Science, Nov 2015
The lentiviral Nef protein helps viruses evade innate and adaptive immune defenses by hijacking the adaptor protein 1 (AP-1) and AP-2 clathrin adaptors.
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.
Göttlinger et al., Worcester, United States. In Nature, Nov 2015
HIV-1 Nef and the unrelated mouse leukaemia virus glycosylated Gag (glycoGag) strongly enhance the infectivity of HIV-1 virions produced in certain cell types in a clathrin-dependent manner.
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
Pizzato et al., Trento, Italy. In Nature, Nov 2015
HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on host membrane trafficking and receptor downregulation.
Antagonism of aminoacid transport in primary CD4 T cells by HIV-1 Vpu.
Lehner et al., Manchester, United Kingdom. In Lancet, Mar 2015
Novel substrates of the viral accessory proteins Vpu and Nef were sought by use of deletion viruses and single gene overexpression.
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine.
HVTN 505 Study Team et al., Aş Şanamayn, Syria. In N Engl J Med, 2013
The 6-plasmid DNA vaccine (expressing clade B Gag, Pol, and Nef and Env proteins from clades A, B, and C) was administered at weeks 0, 4, and 8.
Impact of frequent nocturnal hemodialysis on myocardial mechanics and cardiomyocyte gene expression.
Rakowski et al., Toronto, Canada. In Circ Cardiovasc Imaging, 2012
Uremia clearance using NHD is accompanied by improvement in LV strain, rotation, reduction in mass and volume index. Dialysis downregulates genes for cardiomyocyte apoptosis and fibrosis and upregulates S100A1, which may improve LV contractility.
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.
Teisinger et al., Praha, Czech Republic. In J Biol Chem, 2012
Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel.
[Jugular venous and arterial concentrations of serum S100B protein in patients with severe head injury].
Sapin et al., Clermont-Ferrand, France. In Ann Biol Clin (paris), 2012
Determination of S100B concentration in jugular samples appears to be better than in arterial to predict clinical outcome after brain injury.
S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.
Kobayashi et al., Japan. In J Biol Chem, 2012
S100A1 and permanently active S100P inhibited the apoptosis signal-regulating kinase 1 (ASK1) and PP5 interaction, resulting the inhibition of dephosphorylation of phospho-ASK1 by PP5
S100B serves as a Ca(2+) sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina.
Sharma et al., Boston, United States. In Cell Physiol Biochem, 2011
S100B is expressed in mouse photoreceptor cone outer segments but not in rods.
More papers using S-100 antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Adam Patrick et al., In Diagnostic Pathology, 2006
... S100DAKO ...
qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data.
Mallucci Giovanna R., In PLoS ONE, 2006
... protein zero () (1∶1000 in WB); polyclonal anti-glyceraldeyde 3 phosphate deydrogenase (I-19) (Santa Cruz, Biotechnology), a monoclonal anti-S100 antibody (Abcam), a monoclonal anti-myelin protein zero ...
Beta-catenin and E-cadherin expression in salivary gland tumors
Manni J. J. et al., In European Archives of Oto-Rhino-Laryngology, 2005
... The immuno-histochemical panel contained antibodies against pankeratin (clone MNF116, 1:500, DAKO), S100 protein (1:5,000, DAKO) and Alfa smooth muscle ...
Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
Simmet Thomas et al., In Journal of Biomedicine and Biotechnology, 2004
... Cruz, CA); actin-Chemicon International (Chemicon, Temecula, CA); HLA-DR, CD80, CD86, and CD1a-BD Biosciences (Heidelberg, Germany); S100 [28]-AbD SeroTec (Oxford, UK) ...
Tularemia in Denmark: identification of a Francisella tularensis subsp. holarctica strain by real-time PCR and high-resolution typing by multiple-locus variable-number tandem repeat analysis
Wakasa Haruki et al., In Virchows Archiv, 2004
... Takeya, Kumamoto, Japan), Langerin (Novocastra Laboratories Ltd.), S-100 (Dako), D2-40 (Nichirei Corp.), Fascin, ...
Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
Hummler Edith et al., In Nature Communications, 2003
... ) F4/80 and S100-positive cells in skin of 2-day-old transgenic and littermate controls ...
Serum S100B levels in patients with cerebral and extracerebral infectious disease
Gonçalves Carlos-Alberto et al., In Journal of Neuroinflammation, 2003
... Polyclonal anti-S100B and anti-rabbit peroxidase linked were purchased from DAKO [São Paulo, Brazil] and ...
Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice
Blokx Willeke A. M. et al., In Acta Neuropathologica, 2003
... Slides were then incubated at room temperature with antibodies to S-100 protein (polyclonal, 1:800, Dako Co., Lot 00060051), Melan-A ...
Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase.
Jeyaseelan Samithamby, In PLoS ONE, 2002
... Biotechnology (Santa Cruz, CA); an anti-mouse CD146 Ab FITC-conjugated from Biolegend (San Diego, CA), a rabbit anti-S100B Ab from BD Biosciences, and a rabbit anti-CD54 Ab ...
hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
Itohara Shigeyoshi et al., In Frontiers in Behavioral Neuroscience, 2000
... S100b-Cre transgenic mice ...
Cutting edgeidentification of GL50, a novel B7-like protein that functionally binds to ICOS receptor
Moser Bernhard et al., In The Journal of Experimental Medicine, 1999
... (L26), CD21 (1F8), CD25 (ACT-1), and CD31 (JC/70A), rabbit IgG to CD3 (A0452), and bovine S-100 were from Dako; mouse antibodies to CCR3 (7B11) and CCR5 (5C7) were from LeukoSite, Inc.; and mouse antibody to HLA-DR (L243) was from Research Diagnostics Inc ...
Regulation of gene expression in vivo following transduction by two separate raav vectors
Cucchiarini Magali et al., In Sarcoma, 1997
... the anti-Ki-67 (PP-67) and anti-SOX9 (C-20) antibodies from Santa Cruz Biotechnology (Heidelberg, Germany), and the anti-S-100 (Z0311) antibody from Dako Deutschland GmbH (Hamburg, Germany) ...
Viral dynamics in human immunodeficiency virus type 1 infection
Koyanagi Yoshio et al., In Frontiers in Microbiology, 1994
... Cells were counted by staining them with an anti-SIV Nef monoclonal antibody (04–001, Santa Cruz Biotechnology, Santa Cruz, CA) labeled ...
Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrsarcoma
Mentzel Thomas et al., In Virchows Archiv, 1987
... S-100 proteinpolyclonal1:2000DAKO, Glostrup, Denmark ...
Studies on experimental malignant nerve sheath tumor maintained in tissue and organ culture system
Rubin Brian P et al., In Rare Tumors, 1975
... paraffin-embedded tissue by the avidin-biotin-peroxidase complex technique using commercially available antibodies to the following antigens: S-100 (polyclonal; 1:8000; DAKO, Carpinteria, CA, USA), HMB-45/50 ...
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